This trial is looking to examine the use of radiation on a shorter schedule of 5 days in a row is a safe and effective way to prevent breast cancer (BC) from coming back in people who have had a mastectomy (surgical removal of the breast). The main outcomes that are to be measured are local and regional disease recurrence. This trial is to be carried out in New York, the United States.
BC is one of the most common cancers found in women globally. The standard treatment for BC is surgery, chemotherapy, and radiotherapy.
This trial examines the effectiveness of a compressed or shorter radiotherapy treatment schedule on BC recurrence following breast reconstruction surgery. The main outcomes to be measured are local and regional cancer recurrence.
Who are they looking for?
This trial is looking to recruit 72 patients who have had chest wall reconstruction following breast removal surgery.
Patients will be excluded from this trial if they have cancer spread to distant body parts (metastases) or have had radiation therapy to the torso. Patients with uncontrolled infections of medical conditions, another cancer, or who are receiving anti-cancer treatment will also be excluded. Women who are breastfeeding or are pregnant will not be allowed to participate.
How will it work
All patients in the trial will receive external beam radiotherapy. This will be given in 5 treatments on 5 consecutive days during 1 week. Each dose will be 5.2 Gy.
Participants will be followed up for 3 years and disease recurrence and complications will be evaluated.