In a nutshell This study evaluated the long-term effects of exercise and regular physical activity in patients with early Parkinson’s disease (PD). The data showed that in the long-term, the maintenance of high regular physical activity levels and exercise habits were strongly associated with better clinical outcomes of PD symptoms. Some...
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In a nutshell This study evaluated the effectiveness and safety of ropinirole (Requip) for the treatment of patients with Parkinson’s disease (PD). The data showed that ropinirole was effective in improving motor function and daily living of patients with PD but was associated with an increase in side effects. Some background Parkinson's...
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In a nutshell In this work, the authors studied whether VY-AADC01 (NBIb-1817) gene therapy was safe and effective in patients with moderately advanced Parkinson's disease (PD) patients with motor fluctuations. The authors showed that this treatment caused an improvement in motor function, quality of life, and a decrease in the level of...
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In a nutshell This study evaluated the effectiveness and safety of the ND0612 delivery system of levodopa/carbidopa (Sinemet) in patients with Parkinson's disease (PD). The authors showed that the system was well-tolerated and safe and that it reduced the fluctuations of the levodopa plasma levels. Some background Parkinson's...
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In a nutshell In this work, the authors evaluated the effectiveness of safinamide (Xadago) on mood in patients with Parkinson's disease (PD). The study showed that safinamide improved PD patients' mood and emotional wellbeing at 6 months. Some background Parkinson's disease (PD) is the second most common...
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In a nutshell This study looked at the effects of long-term physiotherapy (6 months or more) on patients with Parkinson's disease. It found that patients doing long-term physiotherapy had fewer symptoms during the "off" medication phase, and needed lower doses of levodopa (Sinemet) to manage their symptoms compared to patients not...
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In a nutshell This study looked at how motor symptoms progressed in patients with Parkinson's disease (PD), before and during the COVID-19 pandemic. It found that motor symptoms progressed more quickly during the first 15 months of the pandemic than during the 15 months before it. Some background PD symptoms involving muscles and...
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In a nutshell This study looked at the effect of safinamide (Xadago) on rapid eye movement (REM) sleep behavioral disorder (RBD) in patients with Parkinson's disease (PD). It found that safinamide 50 mg daily improved RBD symptoms in these patients. Some background Patients with PD sometimes suffer from REM sleep...
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In a nutshell This study looked at the effectiveness of deep brain stimulation (DBS) in patients with Parkinson's disease (PD) and stomach problems. It found that DBS was associated with an improvement in stomach disorders and a reduced need for medication. Some background PD is a neurologic condition that can be difficult to treat as...
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In a nutshell This study looked at the use of levodopa-carbidopa intestinal gel (LCIG; Duodopa) for the treatment of severe dyskinesia in patients with advanced Parkinson's disease (PD). It found that LCIG improved symptoms in most patients but that dose adjustments were needed throughout treatment. Some background Parkinson's...
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In a nutshell This study investigated the association between smoking cigarettes and psychosis in patients with Parkinson´s disease (PD). Researchers suggested that smoking may increase the risk of psychotic symptoms in PD patients. Some background PD is a chronic disease that affects the brain cells over time. Brain cells are responsible...
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In a nutshell This study investigated the effectiveness of a treatment program with physical therapy and music (PTM) for patients with Parkinson´s disease. Researchers suggested that PTM improved the quality of life of these patients. Some background Parkinson´s disease affects brain cells. These cells stop controlling body functions...
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