In a nutshell This study looked the effect of treatments for BPH and lower urinary tract symptoms on male sexual function and health. It concluded that more invasive surgeries had more of an impact on sexual function. Some background Benign Prostatic Hyperplasia (BPH) is a non-cancerous enlargement of the prostate gland. An enlarged prostate...
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What type of breast cancer radiotherapy is safe for the skin?
In a nutshell This study aimed to find out which type of radiation therapy was safest for the skin in the treatment of breast cancer. The authors found that Image-Guided Radiation Therapy treatment resulted in less severe skin damage compared to the intensity-modulated type. Some background Image-guided radiation therapy (IGRT) is the use of...
Read MoreUsing focal lesions seen on PET-CT to monitor outcome in multiple myeloma
In a nutshell This study examined the use of PET-CT imaging to monitor response to treatment for multiple myeloma. The study concluded that treatment to suppress focal lesions seen on PET-CT is an important goal for newly diagnosed patients. Some background One way to improve outcomes in multiple myeloma is to customize treatment based on the...
Read MoreDrug interactions with tyrosine kinase inhibitors in chronic myeloid leukemia
In a nutshell This study investigated the interactions between tyrosine kinase inhibitors and other drugs taken at the same time in patients with chronic myeloid leukemia. This study concluded that drug interactions were found in a significant number of patients, with mild side effects. Some background Imatinib (Gleevec) and similar drugs are the...
Read MoreFulvesterant compared to aromatase inhibitors in HR+ advance breast cancer in post-menopausal women
In a nutshell This study aimed to look at the safety and effectiveness of fulvesterant (Faslodex) compared to aromatase inhibitors in post-menopausal women with hormone receptor positive (HR+) breast cancer. The authors found that fulvestrant was a safe and effective treatment in these patients when compared to aromatase inhibitors. Some...
Read MoreDoes Sentinel Lymph Node Biopsy Increase Survival in Patients with Thick Melanoma?
In a nutshell This study investigated whether Sentinel Lymph Node (SLN) biopsy increases survival in patients with thick melanoma. The study found that SLN biopsy was associated with an increase in disease free survival (DFS) in patients with melanoma. Some background Sentinel lymph node (SLN) biopsy is used to identify whether tumour has started...
Read MorePlerixafor: does weight-based or fixed-dose affect hematopoietic stem cell movement in non-Hodgkin’s lymphoma?
In a nutshell This study investigated the effects of fixed-dose (FD) and weight-based (WB) dose plerixafor (Mozobil) on hematopoietic stem cell (HSC) movement in patients with Non-Hodgkin’s lymphoma (NHL) weighing less than 11 stone. The main finding was that there was no significant difference in HSC movement with WB or FD plerixafor. Some...
Read MorePredicting success for Collagenase clostridium histolyticum treatment in Peyronie’s disease
In a nutshell This study looked at the effectiveness of injection of Collagenase Clostridium histolyticum (Xiaflex) (CCh) to treat Peyronie's disease. This study concluded CCh was effective after injection, in the treatment of patients with more severe Peyronie's disease. Some background Peyronie’s disease is a...
Read MoreSingle vs standard slings for stress incontinence
In a nutshell This study compared the long term effectiveness of single incision mini slings against standard mid-urethral slings in female patients with stress urinary incontinence. This study concluded that long term standard mid-urethral slings are more effective but single incision mini slings show reduced complications after surgery in women with...
Read MorePelvic floor muscle training for women with overactive bladder syndrome?
In a nutshell This study looked at the effectiveness of pelvic floor muscle training in women with overactive bladder syndrome (OAB). This study concluded that pelvic floor muscle training did not improve OAB symptoms in women. Some background Overactive Bladder (OAB) is a sudden, frequent urge to urinate. It may result in urge incontinence (unable to...
Read MoreHave survival rates improved for patients treated for Metastasis from Uveal Melanoma?
In a nutshell This study investigated if there has been an improvement in survival after treatment in patients with metastasis from uveal melanoma. The study found no significant improvement in survival rates in patients who were treated for metastasis from uveal melanoma. Some background Despite successful treatment of tumors in patients who are...
Read MoreCan white blood cell count be used to predict if cancer will reoccur in patients with melanoma?
In a nutshell This study investigated if there was a relationship between Neutrophil-to-Lymphocyte ratio (NLR) and cancer recurrence (cancer coming back) in patients with melanoma. The results found that a high NLR was a strong predictor for disease recurrence in patients with melanoma. Some background Neutrophil and lymphocytes are white...
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