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Seeking patients with relapsed follicular lymphoma for dosing study of idelalisib

Seeking patients with relapsed follicular lymphoma for dosing study of idelalisib

Posted by on Sep 20, 2020 in Non-Hodgkin lymphoma | 0 comments

In a nutshell This study will evaluate the best dose of idelalisib (Zydelig) for patients with relapsed follicular lymphoma (FL). The primary outcomes are overall response and side effects.  The details FL is a slow-growing cancer of B-cells, a type of white blood cell. Idelalisib is a medication that inhibits certain proteins involved in...

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Looking for patients with advanced breast cancer to trial an experimental drug treatment.

Looking for patients with advanced breast cancer to trial an experimental drug treatment.

Posted by on Sep 20, 2020 in Breast cancer | 0 comments

In a nutshell This trial is aiming to examine the effectiveness of an experimental drug, AMXI-5001, in patients with advanced breast cancer. The main outcomes that are to be measured in this trial are side effects and the response to treatment. This trial is going to be carried out in California, Tennessee, and Florida, the United States. The...

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Looking for patients with diabetic eye disease to trial a delivery system for ranibizumab.

Looking for patients with diabetic eye disease to trial a delivery system for ranibizumab.

Posted by on Sep 20, 2020 in Diabetes mellitus | 0 comments

In a nutshell This trial is being carried out to assess the effectiveness of a port delivery system (PDS) loaded with ranibizumab (Lucentis) in order to prevent further progression of diabetic retinopathy (DR; diabetic eye disease). The main outcome of this trial is to assess the improvement in DR following implantation with a PDS. This trial...

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Long-term outcomes of daratumumab, bortezomib, and dexamethasone in previously treated patients with multiple myeloma.

Long-term outcomes of daratumumab, bortezomib, and dexamethasone in previously treated patients with multiple myeloma.

Posted by on Sep 20, 2020 in Multiple Myeloma | 0 comments

In a nutshell This trial was carried out to examine the long-term safety and effectiveness of daratumumab (Darzalex) plus bortezomib (Velcade) and dexamethasone (Dexasone) in patients with previously treated multiple myeloma (MM). The authors concluded that after 3-years this treatment maintained benefit and...

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Managing non-ST elevation myocardial infarction in the elderly – is an invasive or non-invasive approach more suitable?

Managing non-ST elevation myocardial infarction in the elderly – is an invasive or non-invasive approach more suitable?

Posted by on Sep 20, 2020 in Coronary artery disease | 0 comments

In a nutshell This study investigated the management of non-ST elevation myocardial infarction (NSTEMI) in elderly patients. They found that invasive management had better survival rates for these patients.  Some background Coronary artery disease (CAD) is caused by reduced blood flow to the heart. This can be caused by blockages. CAD can...

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Does freezing of embryos improve live birth rates in women of advanced reproductive age?

Does freezing of embryos improve live birth rates in women of advanced reproductive age?

Posted by on Sep 20, 2020 in Infertility | 0 comments

In a nutshell This study investigated live birth rates (LBRs) in women that underwent frozen (Fz) embryo transfer (ET).  They found that LBRs were higher with Fz-ET in women under 35, but there was no difference between Fz and fresh (Fr) ET in those older than 35. Some background Infertility is a common condition. Assisted reproductive technology...

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The impact of G-CSF on brentuximab vedotin plus chemotherapy in treating newly diagnosed advanced Hodgkin lymphoma

The impact of G-CSF on brentuximab vedotin plus chemotherapy in treating newly diagnosed advanced Hodgkin lymphoma

Posted by on Sep 20, 2020 in Hodgkin's lymphoma | 0 comments

In a nutshell The study evaluated the impact of granulocyte-colony stimulating factor (G-CSF; Neupogen) on the outcomes of brentuximab-vedotin (BV; Adcetris) plus chemotherapy in newly diagnosed patients with stage-III/IV Hodgkin lymphoma (HL). The authors found that G-CSF improved the safety and efficacy outcomes of the combination therapy in such...

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Evaluating the safety and effectiveness of polyethylene glycol loxenatide in patients with T2D

Evaluating the safety and effectiveness of polyethylene glycol loxenatide in patients with T2D

Posted by on Sep 20, 2020 in Diabetes mellitus | 0 comments

In a nutshell This study examined the effectiveness and risks of polyethylene glycol loxenatide (PEX168) as an add-on to metformin (Glucophage) therapy in patients with type 2 diabetes (T2D). It found that PEX168 is safe and works effectively in improving the blood sugar levels in these patients. Some background T2D is a...

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Real-time vs flash monitoring for T1D

Real-time vs flash monitoring for T1D

Posted by on Sep 20, 2020 in Diabetes mellitus | 0 comments

In a nutshell This study compared real-time continuous glucose monitoring (CGM) to flash CGM for patients with type 1 diabetes (T1D). It found that real-time CGM led to better glucose control and less hypoglycemia, both during daily activity and exercise. Some background Patients with T1D are unable to create the hormone insulin to regulate blood...

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Evaluating haploidentical stem cell transplantation for advanced lymphoma

Evaluating haploidentical stem cell transplantation for advanced lymphoma

Posted by on Sep 20, 2020 in Non-Hodgkin lymphoma | 0 comments

In a nutshell This study looked at the effect of a gentler stem cell transplant (SCT) from a partially matched donor for patients with advanced lymphoma. It found that haploidentical SCT is an effective treatment option for these patients. Some background Lymphomas are a group of cancers of white blood cells within the lymph nodes. Common types...

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Evaluating haploidentical stem cell transplantation for advanced lymphoma

Evaluating haploidentical stem cell transplantation for advanced lymphoma

Posted by on Sep 20, 2020 in Hodgkin's lymphoma | 0 comments

In a nutshell This study looked at the effect of a gentler stem cell transplant (SCT) from a partially matched donor for patients with advanced lymphoma. It found that haploidentical SCT is an effective treatment option for these patients. Some background Lymphomas are a group of cancers of white blood cells within the lymph nodes. Common types...

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