In a nutshell This study will evaluate the best dose of idelalisib (Zydelig) for patients with relapsed follicular lymphoma (FL). The primary outcomes are overall response and side effects. The details FL is a slow-growing cancer of B-cells, a type of white blood cell. Idelalisib is a medication that inhibits certain proteins involved in...
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In a nutshell This trial is aiming to examine the effectiveness of an experimental drug, AMXI-5001, in patients with advanced breast cancer. The main outcomes that are to be measured in this trial are side effects and the response to treatment. This trial is going to be carried out in California, Tennessee, and Florida, the United States. The...
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In a nutshell This trial is being carried out to assess the effectiveness of a port delivery system (PDS) loaded with ranibizumab (Lucentis) in order to prevent further progression of diabetic retinopathy (DR; diabetic eye disease). The main outcome of this trial is to assess the improvement in DR following implantation with a PDS. This trial...
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In a nutshell This trial was carried out to examine the effectiveness of azilsartan medoxomil (Edarbi; AZM) on lowering blood pressure (BP) in a Chinese population. The trial found that AZM was similar to valsartan (Diovan) at a 40mg-dose and more effective at a 80mg-dose. Some background One class of drugs used to...
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In a nutshell This trial was carried out to examine the long-term safety and effectiveness of daratumumab (Darzalex) plus bortezomib (Velcade) and dexamethasone (Dexasone) in patients with previously treated multiple myeloma (MM). The authors concluded that after 3-years this treatment maintained benefit and...
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In a nutshell This study investigated the management of non-ST elevation myocardial infarction (NSTEMI) in elderly patients. They found that invasive management had better survival rates for these patients. Some background Coronary artery disease (CAD) is caused by reduced blood flow to the heart. This can be caused by blockages. CAD can...
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In a nutshell This study investigated live birth rates (LBRs) in women that underwent frozen (Fz) embryo transfer (ET). They found that LBRs were higher with Fz-ET in women under 35, but there was no difference between Fz and fresh (Fr) ET in those older than 35. Some background Infertility is a common condition. Assisted reproductive technology...
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In a nutshell The study evaluated the impact of granulocyte-colony stimulating factor (G-CSF; Neupogen) on the outcomes of brentuximab-vedotin (BV; Adcetris) plus chemotherapy in newly diagnosed patients with stage-III/IV Hodgkin lymphoma (HL). The authors found that G-CSF improved the safety and efficacy outcomes of the combination therapy in such...
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In a nutshell This study examined the effectiveness and risks of polyethylene glycol loxenatide (PEX168) as an add-on to metformin (Glucophage) therapy in patients with type 2 diabetes (T2D). It found that PEX168 is safe and works effectively in improving the blood sugar levels in these patients. Some background T2D is a...
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In a nutshell This study compared real-time continuous glucose monitoring (CGM) to flash CGM for patients with type 1 diabetes (T1D). It found that real-time CGM led to better glucose control and less hypoglycemia, both during daily activity and exercise. Some background Patients with T1D are unable to create the hormone insulin to regulate blood...
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In a nutshell This study looked at the effect of a gentler stem cell transplant (SCT) from a partially matched donor for patients with advanced lymphoma. It found that haploidentical SCT is an effective treatment option for these patients. Some background Lymphomas are a group of cancers of white blood cells within the lymph nodes. Common types...
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In a nutshell This study looked at the effect of a gentler stem cell transplant (SCT) from a partially matched donor for patients with advanced lymphoma. It found that haploidentical SCT is an effective treatment option for these patients. Some background Lymphomas are a group of cancers of white blood cells within the lymph nodes. Common types...
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