In a nutshell This study compared three drugs to see which was better at improving blood flow and reducing inflammation after patients with heart disease were given a stent. The results showed that prasugrel (Efient) improved patients’ blood flow more than clopidogrel (Plavix) or ticagrelor (Brilique). Some background Heart disease,...
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Which insulin is better for reducing blood glucose levels before hypoglycemia occurs?
In a nutshell This study compared two insulin types – degludec (Tresiba) and glargine (Lantus) – to see which was better at reducing blood glucose levels before hypoglycemia (dangerously low blood glucose levels) occurred. The study found that degludec improved blood glucose levels for longer than glargine before patients experienced...
Read MoreEvaluating a method to predict the outcomes of patients with chronic myeloid leukemia treated with imatinib
In a nutshell The study tested whether the EUTOS long-term survival (ELTS) score is efficient to evaluate treatment response in patients with chronic myeloid leukemia (CML), treated with imatinib (Gleevec). The main finding was that ELTS could effectively predict treatment outcomes among such patients in the real world. Some background Initial...
Read MoreHow did availability of ibrutinib change the treatment of chronic lymphocytic leukemia?
In a nutshell The study compared treatments in patients with chronic lymphocytic leukemia (CLL), before and after Ibrutinib (Imbruvica) became available in British Columbia, Canada. The authors found that ibrutinib replaced chemoimmunotherapy for treating relapse and improved survival among patients. Some background Chemoimmunotherapy (CIT) was the...
Read MoreInitial treatment of Hodgkin lymphoma in older patients
In a nutshell This study reviewed treatment options for older patients newly diagnosed with classical Hodgkin lymphoma (cHL). It found that treatments including brentuximab vedotin (BV: Adcetris) are effective in this age group and that avoiding bleomycin (Blenoxane) prevents lung damage. Some background Around 20% of patients diagnosed with cHL...
Read MoreCurrent treatment for advanced classical Hodgkin lymphoma
In a nutshell This review summarizes current treatment options of advanced classical Hodgkin lymphoma. It found that PET-scan based treatment minimizes long-term side effects and that both ABVD and eBEACOPP are useful chemotherapy regimens. Some background Classical Hodgkin lymphoma (cHL) is a cancer of white blood cells. If cancerous...
Read MoreCan mindfulness-based counseling improve mental health for women with infertility?
In a nutshell This study looked at whether group mindfulness sessions reduced depression in women undergoing in vitro fertilization (IVF). It found women who received 8 sessions of mindfulness training had less depression afterward. Some background Infertility affects over 10% of couples worldwide. Infertility is emotionally challenging. There...
Read MoreAre miscarriages related to an abnormal number of chromosomes in the embryo?
In a nutshell This study looked at whether couples who had repeated miscarriages or lack of implantation were more likely to have embryos with an unusual number of chromosomes (aneuploidy). It found that couples with repeated past miscarriages were more likely to have aneuploid embryos. Some background When eggs and sperm form, pairs of chromosomes...
Read MoreNCCN guidelines for acute myeloid leukemia
In a nutshell These guidelines aimed to provide the latest guidelines on managing acute myeloid leukemia. Some background Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults. Recent advances have led to new treatment options for AML such as targeted therapies and low-intensity...
Read MoreMonitoring of asparaginase treatments for childhood acute lymphoblastic leukemia and non-Hodgkin lymphoma
In a nutshell This study aimed to investigate the activity of two types of asparaginase drugs in pediatric patients with acute lymphoblastic leukemia or non-Hodgkin lymphoma. This study concluded that this type of treatment needs close monitoring for optimal effectiveness. Some background Asparaginase (ASNase) is a drug used in the treatment of...
Read MoreMonitoring of asparaginase treatments for childhood acute lymphoblastic leukemia and non-Hodgkin lymphoma
In a nutshell This study aimed to investigate the activity of two types of asparaginase drugs in pediatric patients with acute lymphoblastic leukemia or non-Hodgkin lymphoma. This study concluded that this type of treatment needs close monitoring for optimal effectiveness. Some background Asparaginase (ASNase) is a drug used in the treatment of...
Read MoreHow does weight loss surgery affect rheumatoid arthritis disease activity?
In a nutshell This study investigated the effect of bariatric surgery (BS; weight loss surgery) in patients with rheumatoid arthritis (RA). They found that BS was associated with lower disease activity in patients with RA and obesity. Some background Rheumatoid arthritis (RA) is a chronic condition. It is caused by excessive...
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