In a nutshell This study compared data from clinical trials investigating if dipeptidyl peptidase-4 (DPP-4) inhibitors are associated with a greater risk of arthralgia (joint pain) in type 2 diabetes patients. They found there was slight increased risk for developing arthralgia in patients taking DPP-4 inhibitors. Some background Managing...
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Does dapagliflozin reduce the risk of cardiovascular complications in patients with type 2 diabetes?
In a nutshell This study investigated if dapagliflozin reduces the risk of developing cardiovascular complications in patients with type 2 diabetes. They found that dapagliflozin was associated with a lower risk of non-fatal heart attack and stroke compared to dipeptidyl peptidase-4 inhibitors (DPP-4i). Some background Cardiovascular (CV, heart...
Read MoreIncidence of side effects associated with common targeted therapy drug
In a nutshell This meta-analysis aimed to establish the incidence of severe and fatal side effects associated with crizotinib (Xalkori) in patients with ALK-positive non-small-cell lung cancer (NSCLC). The authors concluded that crizotinib does not increase the risk of severe or fatal side effects compared to chemotherapy. Some background The...
Read MoreDurvalumab improves time to disease progression in previously treatment non-small cell lung cancer
In a nutshell This study examined the safety and effectiveness of durvalumab (Imfinzi) in patients with stage III non-small cell lung cancer. This study concluded that durvalumab delayed time to disease progression. Some background Chemotherapy and radiation are the standard treatment options for stage III non-small cell lung cancer (NSCLC, cancer...
Read MoreComparing chemotherapy regimes for newly diagnosed acute myeloid leukaemia.
In a nutshell This study aimed to compare two induction chemotherapy regimes in patients with acute myeloid leukemia. This study concluded that both chemotherapy regimes investigated had similar benefits in patients with acute myeloid leukemia. Some background Acute myeloid leukemia (AML) occurs when abnormal myeloblasts are produced....
Read MoreAdding mitoxantrone to oral FCR (fludarabine, cyclophosphamide & rituximab) does not improve treatment response
In a nutshell This study examined whether adding mitoxantrone (Novantrone) to the treatment combination known as FCR improves outcomes for chronic lymphocytic leukemia (CLL). Researchers reported no significant benefit when mitoxantrone was added to FCR. Some background For physically fit CLL patients, the chemotherapy and immunotherapy...
Read MorePembrolizumab in patients with chronic lymphocytic leukemia with Richter’s transformation
In a nutshell This study examined the safety and effectiveness of pembrolizumab in the treatment of chronic lymphocytic leukemia that has undergone Richter’s transformation. This study concluded that patients with Richter’s transformation responded to pembrolizumab. Some background Chronic lymphocytic leukemia is a cancer where...
Read MoreSmoking increases the risk for spread of colorectal cancer to the lungs
In a nutshell This study assessed whether smoking increased the chance for spread of colorectal cancer (CRC) to the lungs. The study found that smoking may be a risk factor for cancer spread to the lungs. Some background Smoking is a known risk factor for colorectal cancer. Colorectal cancer is commonly known to spread to the liver when...
Read MoreTreatment outcomes in 477 patients with blast-phase CML
In a nutshell This study examined treatment outcomes in patients with blast-phase chronic myeloid leukemia (CML). Authors reported that intensive treatment early followed by stem cell transplantation remains as the most effective approach. Certain patient characteristics and treatment history are significant predictors of outcomes. Some...
Read MoreCAR-T cells to treat chronic lymphocytic leukemia after failure of ibrutinib
In a nutshell This paper studied the effect of lymphodepletion chemotherapy and CAR-T cell infusion in patients with chronic lymphocytic leukemia who did not respond to ibrutinib (Imbruvica) therapy. This was found to be a highly effective treatment. Some background Chronic lymphocytic leukemia (CLL) is a cancer of the blood forming cells....
Read MorePreventing fungal infections after chemotherapy in acute leukemia patients
In a nutshell The aim of this study was to examine the effect of preventative fungal treatment in acute leukemia patients with different risk factors. Researchers identified a number of risk factors that can increase the incidence of a severe fungal infection after chemotherapy. Preventative fungal treatment for patients undergoing primary chemotherapy...
Read MoreInotuzmab ozogamicin as a treatment option for patients with acute lymphoblastic leukaemia.
In a nutshell This study aimed to investigate if inotuzumab ozogamicin (Besponsa) is a more effective treatment than the standard therapy for relapsed acute lymphoblastic leukemia. This study concluded that inotuzumab ozogamicin is a more effective treatment than standard therapy for relapsed acute lymphoblastic leukemia. Some background...
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