In a nutshell This study aimed to compare outcomes of fludarabine–treosulfan (FT), thiotepa–busulfan–fludarabine (TBF), and fludarabine, Ara-C, amsacrine, total body irradiation/busulfan, cyclophosphamide (FLAMSA) in the treatment of patients with relapsed or unresponsive acute myeloid leukemia (AML). The study found that all...
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Evaluating higher dose of dulaglutide added to metformin for type 2 diabetes
In a nutshell This article investigated the safety and effectiveness of higher doses of dulaglutide (Trulicity) in the management of type 2 diabetes (T2DM) in patients on metformin (Glucophage). The authors concluded that the higher doses of dulaglutide are effective and safe in these patients. Some background In T2DM the...
Read MoreEvaluating busulfan plus melphalan conditioning for patients with multiple myeloma before stem cell transplantation
In a nutshell This study evaluated the safety and effectiveness of busulfan (Myleran) plus melphalan (Alkeran) compared to melphalan alone for patients with multiple myeloma (MM) before autologous stem cell transplantation (ASCT). This study concluded that the combination treatment was more effective for these patients. Some background...
Read MoreEvaluating polatuzumab vedotin and pinatuzumab vedotin for relapsed or refractory NHL
In a nutshell This study evaluated the safety and effectiveness of rituximab (Rituxan) combined with either polatuzumab vedotin (pola) or pinatuzumab vedotin (pina) for patients with non-Hodgkin’s lymphoma (NHL) that has come back or stopped responding to treatment. This study concluded that pola was associated with better...
Read MorePET scans in determining outcomes for patients with Hodgkin lymphoma treated with chemotherapy
In a nutshell This study aimed to investigate the role of positron emission tomography (PET; an imaging technique) in determining the outcomes for patients with Hodgkin lymphoma treated with chemotherapy. This study concluded that negative-PET scans after chemotherapy predict good outcomes for these patients, regardless of stage at...
Read MoreThe role of external beam radiation therapy in the treatment of prostate cancer.
In a nutshell This study reviewed the role of external beam radiation therapy in the treatment of prostate cancer. Some background Prostate cancer (PC) is a common and treatable cancer in men. There are many treatment options available. Treatment is usually chosen based on the risk of the cancer progressing, and patient...
Read MoreIs Aquablation an effective treatment for urinary symptoms caused by an enlarged prostate?
In a nutshell The authors analyzed the effectiveness of Aquablation compared to other treatments for patients with urinary symptoms caused by an enlarged prostate. The authors concluded that Aquablation is probably as effective as transurethral resection of the prostate (TURP) in these patients. Some background An enlarged prostate may cause...
Read MoreEvaluating palbociclib for patients with previously treated breast cancer
In a nutshell This study evaluated how well palbociclib (Ibrance) works in patients with breast cancer who received multiple lines of previous therapy. This study found that palbociclib was effective for these patients. Some background There are several different treatments for breast cancer depending on the types of...
Read MoreFurther surgery or non-surgical options for patients with remaining breast cancer after surgery
In a nutshell This study evaluated whether treating breast cancer that has not been completely removed with more surgery was more effective than non-surgical options such as chemotherapy. This study found that there was no difference in outcomes between treating with further surgery versus treating with a non-surgical option. Some...
Read MoreProstate cancer: can we predict recurrence?
In a nutshell This study examined the biochemical recurrence (BCR) of prostate cancer after minimally invasive prostate surgery. This study concluded the risk of BCR of prostate cancer decreases as the number of years after surgery without the disease increases. Some background One treatment option for patients with prostate...
Read MoreHigh dose vitamin D supplementation may be associated with improved colorectal cancer outcomes
In a nutshell This study investigated if high-dose vitamin D combined with chemotherapy improves outcomes in patients with metastatic (spread to other parts of the body) colorectal cancer. Researchers suggested that high-dose vitamin D was associated with an improved chance of survival. Some background Vitamin D is associated with the intake of...
Read MoreInitial management with aflibercept, laser photocoagulation or observation in patients with diabetic eye disease?
In a nutshell This article investigated the rate of vision loss at 2 years among eyes with center involved-diabetic macular edema (CI-DME; vision loss in people with diabetes) initially managed with aflibercept (Eylea), laser photocoagulation (LP) or observation. The authors concluded that there was no significant difference in vision loss at 2...
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