In a nutshell This article investigated the safety and effectiveness of triple therapy with low dose dapagliflozin (Farxiga) plus saxagliptin (Onglyza) added to metformin (Glucophage) in uncontrolled type 2 diabetes (T2D). The authors concluded that triple therapy significantly improved blood glucose control in these patients. Some background T2D...
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What is the effect of abnormal insulin on fertility outcomes in polycystic ovarian syndrome?
In a nutshell This study investigated the effect of abnormal insulin responses (AIRs) on fertility outcomes in women with polycystic ovarian syndrome (PCOS). They found that AIRs can predict fertility outcomes in these patients. Some background Polycystic ovarian syndrome (PCOS) is a common cause of infertility. Cysts on the ovaries can...
Read MoreHeart side effects and anthracyline medications – what is the benefit/risk in breast cancer?
In a nutshell This study investigated the effectiveness and side effects on the heart of anthracycline-based therapies (ABTs) for breast cancer. They found that non-doxorubicin (non-DXR) ABTs had a better benefit/risk ratio (BRR) than DXR alone. Some background Anthracycline-based therapies (ABTs) are commonly used to treat breast...
Read MoreHow does vaginal reconstructive surgery impact pain and functional activity?
In a nutshell This study investigated if pain and functional activity (FA) is affected by vaginal reconstructive surgery (VRS). They found that pain and FA improves for up to 2 years. Some background Pelvic organ prolapse (POP) is a condition that affects many women. It can lead to urinary incontinence (UI). UI is the term for an inability to...
Read MoreDoes age influence the safety and effectiveness of stem cell treatment for patients with multiple myeloma?
In a nutshell This study examined the safety and effectiveness of stem cell transplantation (SCT) in elderly patients with multiple myeloma (MM) aged 65 or older compared to younger patients. The authors concluded that SCT was equally as safe and effective for patients in both age groups. Some background Multiple myeloma is a complex type of...
Read MoreUsing IL2 levels to predict outcomes for patients with classical Hodgkin lymphoma
In a nutshell This study investigated whether interleukin-2 receptor levels in the blood influenced the outcomes of patients with classical Hodgkin’s lymphoma (cHL). This study concluded that this can be a useful tool for predicting prognosis for these patients. Some background Chemotherapy remains the standard first-line treatment for HL. One...
Read MoreCarfilzomib, thalidomide and dexamethasone in the treatment of multiple myeloma
In a nutshell This study looked at the safety and effectiveness of carfilzomib (Kyprolis), thalidomide (Thalomid) and dexamethasone (Decadron) in the treatment of patients with multiple myeloma. Researchers concluded that this treatment plan is safe and effective in these patients. Some background Multiple myeloma is a cancer of the bone marrow. It is...
Read MoreBusulfan and fludarabine before transplant in the treatment of older patients with acute myeloid leukemia
In a nutshell This study looked at the effectiveness of busulfan (Busilvex) and fludarabine (Fludara) before transplant in the treatment of older patients with acute myeloid leukemia (AML). Researchers found that this treatment was safe and effective in these patients. Some background Acute myeloid leukemia is a cancer of the bone marrow. It...
Read MoreQuizartinib in the treatment of relapsed or unresponsive acute myeloid leukemia
In a nutshell This study compared the safety and effectiveness of quizartinib compared to chemotherapy in the treatment of relapsed or unresponsive acute myeloid leukemia (AML). Researchers found that quizartinib was safer and more effective than chemotherapy in these patients. Some background Acute myeloid leukemia (AML) is a cancer of the bone...
Read MoreUsing alpha-interferon to treat residual chronic myeloid leukemia after transplantation
In a nutshell This study looked at the effectiveness of interferon-alpha (IntronA) treatment in patients with chronic myeloid leukemia (CML) with residual disease after transplantation. Researchers found that this treatment may be useful in patients with signs of disease after transplant. Some background Chronic myeloid leukemia is a cancer...
Read MoreIVF success in patients with endometriosis – surgery or expectant management?
In a nutshell This study investigated live birth rates (LBR) in women surgically-treated for endometriosis (EDM). They found that LBR was similar in women who were surgically-treated and those who did not have surgery. Some background Endometriosis (EDM) is a leading cause of infertility. The endometrium is the tissue lining of the uterus. In...
Read MoreTrastuzumab emtansine plus pertuzumab in patients with HER2-positive breast cancer
In a nutshell This study wanted to find out which treatment was better before surgery for patients with HER2-positive breast cancer, trastuzumab emtansine (Kadcycla) plus pertuzumab (Perjeta), or a standard treatment. The study found that patients treated with trastuzumab emtansine plus pertuzumab (TEP) were more likely to have cancer...
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