In a nutshell This study reviewed early breast cancer (EBC) treatment guidelines. Some background Breast cancer (BC) is a common and treatable form of cancer. Understanding treatment options is important to improve patient care. Treatment options include surgery and radiotherapy (RT). Adjuvant systemic treatment (AST) is a non-surgical option. AST...
Read MoreConfined or spread disease-Confined only to the breast Posts on Medivizor
Radiotherapy during surgery in early breast cancer – what is the risk of tumor recurrence?
In a nutshell This study investigated the safety and effectiveness of intraoperative radiotherapy (IORT; radiotherapy during surgery) in early breast cancer (BC). They found that tumor recurrence was low after IORT. Some background Early breast cancer (BC) can be treated using different approaches. Most patients undergo breast-conserving therapy...
Read MoreLooking for patients with estrogen receptor-positive breast cancer to test a new treatment combination
In a nutshell This phase 2 trial will evaluate the safety and effectiveness of ribociclib (Kisqali) combined with hormonal therapy in patients with estrogen receptor-positive (ER+) breast cancer (BC). The main outcome will be the number of patients that complete 1 year of treatment and survival without signs of cancer. The trial will...
Read MoreDenosumab treatment in HR+ breast cancer
In a nutshell This study wanted to find out if adding the medication denosumab (Prolia, Xgeva) to cancer treatment for women with breast cancer reduces the risk of bone fractures. The study found that the patients treated with denosumab survived better, but there was no significant difference in the number of bone fractures. Some background Breast...
Read MoreIntensity-modulated radiation therapy for advanced breast cancer
In a nutshell This study evaluated the side effects associated with intensity-modulated radiation therapy (IMRT) for advanced breast cancer. This study found that most side effects were mild and did not lower quality of life for patients. Some background Radiotherapy is often performed in breast cancer patients after surgery. Previous studies have...
Read MoreSearching for patients with early-stage HER2+ breast cancer to trial a new treatment regime
In a nutshell This study will examine how safe and effective the medication atezolizumab (Tecentriq) is in combination with other anti-cancer medicines for treating early stage HER2+ breast cancer. The main outcome that will be measured is how many patients completely respond to treatment, with no trace of the cancer remaining. The details...
Read MoreSearching for patients with triple negative breast cancer to test a new medication
In a nutshell This phase 3 trial will investigate the safety and effectiveness of adagloxad simolenin (AGS)/OBI-821 in triple-negative breast cancer (TNBC). The main outcome will be a change in survival without invasive disease. The details Breast cancer (BC) is one of the most common cancers. BC treatment depends on the tumor type....
Read MorePatient-reported outcomes after breast-conserving treatment: what is the impact of radiotherapy?
In a nutshell This study investigated patient-reported outcomes related to radiotherapy (RT) for breast cancer. They found that patients were dissatisfied with outcomes after RT but this was not a long-term effect. Some background Breast cancer is the most common form of cancer in women. A number of strategies are used to treat BC. A lot of BC cases...
Read MoreSearching for patients with early stage breast cancer to trial a new radiation treatment plan
In a nutshell The trial aims to investigate a new way of delivering radiation therapy in women with early-stage breast cancer. This will involve low doses of radiation therapy being aimed at the part of the breast where the tumor is or was. The main outcomes that will be measured are side effects and recurrence rate. This trial is recruiting in Missouri,...
Read MoreSearching for patients with low-risk breast cancer to participate in a study involving radiotherapy
In a nutshell This trial aims to find out if targeted radiotherapy on the breast in women with low-risk breast cancer after breast-conserving surgery will prevent the cancer from coming back. The main outcome that will be measured is how long it takes before the breast cancer comes back. The study is being conducted in Canada and the United States. The...
Read MoreBreast conserving surgery plus radiotherapy vs mastectomy in stage 1 breast cancer
In a nutshell This study wanted to find out which treatment was better for stage 1 breast cancer, either breast-conserving surgery plus radiotherapy, or mastectomy alone. The study found that breast conserving surgery plus radiotherapy was better than mastectomy for patients with stage 1 breast cancer. Some background There are a number of treatment...
Read More10 years of treatment vs 5 years of treatment with hormone therapy in patients with early stage breast cancer.
In a nutshell This study wanted to find out if continuing hormone therapy for 10 years was more effective than doing it for 5 years in patients with early stage breast cancer. The study found that the patients who continued treatment for 10 years survived for longer without the disease coming back compared to those who were only treated for 5...
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