In a nutshell This trial is looking to examine the use of radiation on a shorter schedule of 5 days in a row is a safe and effective way to prevent breast cancer (BC) from coming back in people who have had a mastectomy (surgical removal of the breast). The main outcomes that are to be measured are local and regional disease recurrence. This trial is to...
Read MoreConfined or spread disease-Confined only to the breast Posts on Medivizor
Evaluating radiation therapy after breast removal surgery for node-positive triple-negative breast cancer.
In a nutshell This study was carried out to assess the use of radiotherapy (RT) after mastectomy (surgical removal of the breast) for triple-negative breast cancer (TNBC) that has spread to the lymph nodes. The authors found that RT after surgery was associated with improved survival in patients with larger tumors. Some background Triple-negative...
Read MoreComparing long-term outcomes of whole or partial breast irradiation after breast-conserving surgery
In a nutshell This study compared whole breast irradiation (WBI) to partial breast irradiation (PBI) following breast-conserving surgery (BCS) in patients with low-risk breast cancer. The study showed similar survival between the 2 treatments, while PBI gave better cosmetic results. Some background Patients with low-risk breast...
Read MoreComparing breast-conserving surgery and breast-removal surgery after chemotherapy in patients with breast cancer
In a nutshell This study compared the effectiveness of breast-conserving surgery (BCS) to mastectomy (breast-removal surgery) after chemotherapy in patients with breast cancer. The authors found that BCS does not result in a lower survival in these patients. Some background BC is one of the most common forms of cancer in women. Standard care...
Read MoreComparing hormone therapy and radiation after breast conserving surgery for older patients with early-stage breast cancer
In a nutshell This study compared the survival rates for older patients with early-stage breast cancer (BC) receiving hormone therapy (HT), radiation (RT), both or none after breast-conserving surgery (BCS). The data showed that RT and HT in combination and RT alone may lead to higher survival expectancy than HT alone. Some...
Read MoreImproving the tolerability of neratinib in patients with early-stage HER2-positive breast cancer.
In a nutshell This trial evaluated strategies to improve diarrhea as a side effect of neratinib (Nerlynx) treatment in patients with HER2-positive breast cancer (BC). The authors showed that slowly increasing the doses of neratinib or taking anti-diarrhea medication can improve this side effect. Some background Neratinib (Nerlynx) is a targeted...
Read MoreLong term effects of hypofractionated prone intensity-modulated radiation therapy after breast conservation surgery in patients with breast cancer
In a nutshell The study evaluated long-term outcomes of combining hypofractionated intensity-modulated radiation therapy (H-IMRT) with prone-positioning in patients after conservation surgery for breast cancer. The authors found that this combination safely controlled cancer locally without affecting regional lymph nodes. Some background Adjuvant...
Read MoreThe effects of cholesterol-lowering drugs on breast cancer relapse in postmenopausal women under aromatase inhibitor treatment
In a nutshell The study evaluated the link between statin (cholesterol-lowering drugs) use and risks of breast cancer (BC) relapse under adjuvant aromatase inhibitors (AI) therapy in women after their menopause. The main finding was that statin use was related with lower risks of BC relapse in such patients. Some background Women with...
Read MoreHow effective is hormonal therapy for patients with hormone receptor positive early breast cancer?
In a nutshell This study examined the effectiveness of hormonal therapy in premenopausal women with hormone receptor-positive early breast cancer with or without other treatments. The authors concluded that patients who received hormonal therapy had a higher chance of survival and without a return of cancer. Some background The hormone...
Read MoreSearching for patients with early breast cancer to trial a partial-radiation treatment
In a nutshell This trial aims to find out what dose of radiation therapy is effective in the shortest time period for women with newly diagnosed breast cancer, or ductal carcinoma in-situ (DCIS). The main outcome that will be measured is if patients experience any side effects. The study is taking place in New Jersey and New York, the United States. The...
Read MoreEarly breast cancer – a review of treatment guidelines.
In a nutshell This study reviewed early breast cancer (EBC) treatment guidelines. Some background Breast cancer (BC) is a common and treatable form of cancer. Understanding treatment options is important to improve patient care. Treatment options include surgery and radiotherapy (RT). Adjuvant systemic treatment (AST) is a non-surgical option. AST...
Read MoreRadiotherapy during surgery in early breast cancer – what is the risk of tumor recurrence?
In a nutshell This study investigated the safety and effectiveness of intraoperative radiotherapy (IORT; radiotherapy during surgery) in early breast cancer (BC). They found that tumor recurrence was low after IORT. Some background Early breast cancer (BC) can be treated using different approaches. Most patients undergo breast-conserving therapy...
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