In a nutshell This study compared the safety and effectiveness of neratinib (Nerlynx) plus capecitabine (Xeloda) versus lapatinib (Tykerb) plus capecitabine in patients with human epidermal growth factor (HER2)-positive breast cancer (BC) spread (metastases) to the central nervous system (CNS; brain and spinal cord). The data showed that the...
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In a nutshell This study was carried out to examine the safety and effectiveness of pyrotinib (Irene) in combination with vinorelbine (Navelibine) is in treating metastatic breast cancer (BC). The authors found that this treatment combination showed promising results and was well tolerated in these patients. Some background BC is...
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In a nutshell This study aimed to investigate depression and cognitive (thinking and reasoning) functions after taxane-based chemotherapy in patients with breast cancer. This study concluded taxane-based chemotherapy commonly leads to cognitive impairment in these patients, but some functions improve or remain stable after stopping...
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In a nutshell This study was carried out to examine the impact of physical activity (PA) on the recovery of patients having surgery for breast cancer (BC). The authors found that PA reduces the risk of patients developing chronic pain and women who had higher levels of PA recovered better than sedentary women. Some background BC is one of...
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In a nutshell This study looked at the timing of chemotherapy (CT) after surgery in the treatment of early breast cancer (BC). The authors found that CT given within 31 days after surgery may improve survival in patients with triple-negative (TN) BC. Some background BC is one of the most common types of cancer found in women. There are...
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In a nutshell This study compared the safety and effectiveness between pyrotinib (SHR-1258) and trastuzumab emtansine (T-DM1; Kadcyla) in patients with HER2+ metastatic breast cancer (BC) after previous treatment with trastuzumab (Herceptin) and chemotherapy. The data showed that pyrotinib may be more effective than T-DM1 for these patients. Some...
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In a nutshell This study evaluated the effectiveness and safety of radiofrequency ablation (RFA) for breast cancer (BC) smaller than 2 cm. The data showed that RFA was safe and effective in these patients. Some background Radiofrequency ablation (RFA) is a medical procedure where pieces of tissue are removed using the heat that is produced from an...
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In a nutshell This study aimed to investigate the effects of adherence to hormonal therapy (HT) and radiation on the outcomes of older patients with early-stage breast cancer (BC). This study concluded that the lack of adherence to HT and omitting radiation can lead to poorer outcomes for these...
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In a nutshell This study evaluated the association between patient-reported outcomes (PROs) and survival outcomes in patients with hormone receptor-positive (HR+)/HER2-negative (HER2-) advanced breast cancer (BC) treated with abemaciclib (Verzenio). The data showed that the PROs could be a predictor of survival benefits in these patients. Some...
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In a nutshell This study investigated the effectiveness and safety of sacituzumab govitecan (Trodelvy; SG) compared to chemotherapy in patients with relapsed or refractory metastatic triple-negative breast cancer (mTNBC). The data showed that SG significantly improved the survival outcomes of these patients compared to chemotherapy. Some background...
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In a nutshell This study evaluated the effects and outcomes of adding everolimus (EVE; Afinitor) plus letrozole (LET; Femara) to hormonal therapy for the treatment of premenopausal women with hormone receptor-positive (HR+), HER2-negative (HER2-) advanced breast cancer (BC). The data showed that the combination of EVE+LET improved survival...
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In a nutshell This study evaluated the effectiveness of adding targeted therapy to chemotherapy before surgery for the treatment of patients with inflammatory breast cancer (IBC). The data showed that adding targeted therapy is more effective than chemotherapy alone for these patients. Some background IBC is a rare and aggressive form of...
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