In a nutshell This study aimed to investigate the association between beta blocker use and outcomes in HER2 negative breast cancer (BC) patients. This study concluded that beta blocker use leads to improved progression free survival in BC patients. Some background Beta blockers are therapies used to treat various heart related conditions....
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What are the side effects of non-hormonal drugs for hot flashes?
In a nutshell This study aimed to investigate the frequency and severity of the adverse events associated with non-hormonal drugs (NHD) used to treat hot flashes in breast cancer survivor patients. This study concluded that the use of high-dose NHD led to increased rates of adverse events when compared to patients not using NHD. Some...
Read MoreCan neoadjuvant therapy influence other treatments for breast cancer?
In a nutshell This study aimed to investigate whether neoadjuvant systemic therapy (NST) influenced the eligibility of HER2 positive breast cancer patients to undergo breast conserving therapy (BCT). This study concluded the use of NST can result in patients who are non-eligible for BCT converting to patients that are eligible for BCT. Some...
Read MoreThe impact of beta-blockers, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on BC survival
In a nutshell This study investigated whether beta blockers (BB), angiotensin-converting enzyme inhibitors (ACEi), and angiotensin receptor blockers (ARB) have a beneficial effect on breast cancer-specific survival (BCSS; the time between diagnosis and death from BC). The use of BB was found to be associated with better BCSS survival. Some...
Read MoreA comparison of how FEC120 treatment vs EC-docetaxel treatment affect survival in patients with node-positive primary breast cancer
In a nutshell This study compared the side effects and outcome of two drug regimens in women with high-risk node-positive breast cancer (BC). Both treatment regimens were found to have similar survival outcomes. Some background Standard treatment in node positive BC (cancer that has spread to the lymph nodes) consists of two categories of...
Read MoreThe role of dexamethasone mouthwash in preventing everolimus-related stomatitis in women with breast cancer
In a nutshell This study investigated the use of dexamethasone (Ozurdex) mouthwash for preventing stomatitis in patients with breast cancer(BC). The use of dexamethasone oral solution was found to significantly reduce the incidence and severity of stomatitis. Some background Everolimus (Afinitor) and exemestane (Aromasin) are mTOR inhibitors...
Read MoreThe pre-operative use of accelerated partial breast irradiation in treating early-stage breast cancer
In a nutshell This study investigated whether accelerated partial-breast irradiation (APBI) was useful for preoperative treatment of early-stage breast cancer (BC) patients. APBI was found to be an effective treatment option with good cosmetic results for certain early-stage BC patients. Some background Breast conserving therapy (surgery to remove...
Read MoreHow radiotherapy for breast cancer influences long-term the risk of lung cancer and heart disease
In a nutshell This study investigated the results of previous trials to determine the effects of breast cancer (BC) radiotherapy (RT) on the long-term risk of developing other health conditions later in life. This study determined that for long-term smokers, the future health risks associated with RT may outweigh the benefits. Some background RT...
Read MoreThe effectiveness and cardiac safety of CMF plus trastuzumab in HER2-positive metastatic breast cancer
In a nutshell This study investigated the safety and effectiveness of treatment with combination cyclophosphamide (Cytoxan), methotrexate (Otrexup) and 5-fluoruoracil (Efudex) (CMF) plus trastuzumab (Herceptin) in HER2-positive metastatic breast cancer (MBC, cancer that has spread beyond the breast) patients. CMF plus trastuzumab (CMF+T) was found to...
Read MoreDoes radiotherapy benefit older patients with triple-negative breast cancer
In a nutshell This study investigated the effects of radiotherapy (RT) in older patients with triple-negative breast cancer (TNBC). RT was found to be associated with better survival outcomes for both younger and older patients. Some background TNBC is a form of breast cancer which tests negative for estrogen/ progesterone receptors and human...
Read MoreHow effective is metronomic chemotherapy with vinorelbine and capecitabine in patients with advanced HER2-negative breast cancer?
In a nutshell This study investigated whether metronomic chemotherapy with oral vinorelbine (Navelbine) and capecitabine (Xeloda) was effective in treating patients with advanced HER2-negative breast cancer (BC). This form of treatment was found to be safe and effective for this patients group. Some background Metronomic chemotherapy is a form of...
Read MoreComparing the effects of combined PI3K inhibitor/endocrine therapy versus endocrine therapy alone in ER-positive breast cancer
In a nutshell This study investigated whether the addition of the PI3K inhibitor pictilisib (Stemolecule GDC-0941) can increase the anti-tumor effects of anastrozole (Arimidex) in patients with estrogen receptor-positive (ER-positive) primary breast cancer (BC). Combined treatment with pictilisib (PIC)...
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