In a nutshell This review looked at how often artificial gonadotropin hormones such as human follitropin alpha (Gonal-F) caused ovarian hyperstimulation syndrome (OHSS) or blood clots. It found that these conditions are infrequent side effects of using gonadotropins to stimulate the ovaries. Some background In a natural menstrual cycle,...
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In a nutshell This study investigated the best dose of follitropin delta (FD; Rekovelle) in women undergoing controlled ovarian stimulation (COS). They found that 10 micrograms of FD has similar effectiveness to the standard dose of follitropin alpha (FA; Gonal-F). Some background Assisted reproductive technology (ART)...
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In a nutshell This study investigated preimplantation genetic testing for aneuploidy (PGT-A) in couples with severe male infertility. They found that PGT-A did not improve fertility outcomes in these couples. Some background Infertility affects men and women. Male factor infertility (MFI) is the cause of infertility in 30-50% of...
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In a nutshell This study created a model to predict how well eggs (oocytes) develop embryos during in vitro fertilization (IVF). It found that patients with lower doses of gonadotropin (GN) hormones had better fertilization rates (FR). It also found that patients with diminished ovarian reserve (DOR) could have a high FR. Some background The...
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In a nutshell This study looked at the dose of gonadotropin (GN) used for ovarian stimulation during in vitro fertilization (IVF). It found that cycles with higher GN doses may have lower birth rates. Some background The first stage of the infertility treatment IVF is to stimulate the ovaries to produce multiple follicles. This is most often done...
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In a nutshell This study investigated if vitamin D (VitD) levels affect fertility outcomes after in vitro fertilization (IVF). They found that VitD levels did not seem to be associated with fertility outcomes after IVF. Some background Infertility is a common problem worldwide. Assisted reproductive technology (ART) has improved fertility...
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In a nutshell This review looked at adding hyaluronic acid (HA) to the medium used to grow embryos during in vitro fertilization (IVF). It found that using HA may increase IVF birth rates. Some background The infertility treatment IVF involves fertilizing an egg and allowing it to grow it for several days in the laboratory. The embryos are...
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In a nutshell This study investigated if sperm cryopreservation (freezing) affects fertility outcomes for men with obstructive azoospermia (OA; lack of sperm cells in the semen due to a blockage). The authors found that the clinical pregnancy rate (CPR) was lower with the use of frozen vs fresh epididymal sperm. Some background There...
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In a nutshell This study compared natural cycle (NC) or hormone replacement cycle (HRC) in terms of fertility outcomes in women undergoing frozen embryo transfer (fzET). They found that fertility outcomes were similar with NC or HRC. Some background Assisted reproductive technology (ART) is used to treat infertility. ART includes...
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In a nutshell This study looked at two protocols for in vitro fertilization (IVF) using different timing of medications to suppress the body’s own hormones. It found that patients using a long-acting protocol had fewer embryos with unusual chromosomes (genetic material). Some background Women are born with most of their oocytes (eggs) already...
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In a nutshell This study investigated the rate of testosterone replacement therapy (TRT) in men undergoing assisted reproduction (AR). They found that men undergoing AR were more likely to need TRT. Some background Low testosterone (T) is becoming increasingly common worldwide. Low T in men is associated with a number of conditions. This...
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In a nutshell This study investigated if previous TORCH infections affect outcomes during assisted reproduction (AR) such as in vitro fertilization (IVF) or intracytoplasmatic sperm injection (ICSI). They found that there was no link between previous TORCH infections and negative fertility/neonatal outcomes. Some background A healthy...
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