In a nutshell This study compared progesterone injected under the skin to vaginal progesterone after an embryo transfer. It found that under-the-skin progesterone was just as effective as vaginal progesterone, and led to similar pregnancy rates. Some background In vitro fertilization (IVF) is a common infertility treatment that involves transferring...
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In a nutshell This study looked at whether using two hormone injections to trigger ovulation can improve birth rates from assisted reproductive technology (ART) when all embryos are frozen. It found that cycles with trigger injections of both human chorionic gonadotropin (hCG; Pregnyl) and GnRH agonist (Decapeptyl) had higher birth rates. Some...
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In a nutshell This study looked at the overall birth rate using multiple in vitro fertilization (IVF) cycles and freezing all embryos. It found that when using multiple cycles, the birth rate varied widely depending on the woman’s age and cause of infertility. Some background In vitro fertilization (IVF) is an infertility technique in which the...
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In a nutshell This trial compared intracytoplasmic sperm injection (ICSI) to conventional in vitro fertilization (IVF) for couples where men have normal sperm quality. It found there was no clear benefit to ICSI over IVF for these couples. Some background IVF is an infertility treatment in which the woman’s ovaries are stimulated to produce...
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In a nutshell This review looked at the effect of progesterone on pregnancies at risk of preterm labor. It found that progesterone reduces preterm birth for women with a short cervix or previous preterm birth, but not for women carrying twins. Some background Between 5% and 18% of births are preterm. Births earlier than 37 weeks into the pregnancy, 3...
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In a nutshell This review looked at whether women who used fertility medications more often developed breast cancer later on. It found that women treated with ovarian stimulation had similar rates of breast cancer to other women. Some background Treatment for infertility has become common, both as people have children later, and as the condition is...
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In a nutshell This review compared pregnancy outcomes following two methods of preparing the uterus for a frozen embryo transfer (FET). It found that natural cycle FET led to fewer pregnancy complications than artificial cycle FET. Some background Frozen embryo transfer (FET) is a common infertility treatment is related to in vitro fertilization...
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In a nutshell This study compared how the thickness of the uterine lining affected outcomes from two protocols for in vitro fertilization (IVF). It found that the GnRH antagonist protocol had better outcomes when the lining was of medium thickness. The long GnRH agonist protocol had better outcomes when there was a thick lining. Some background IVF is...
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In a nutshell This review looked at whether genetic testing improved the birth rate from in vitro fertilization (IVF). It found that testing improved birth rates for women over age 35. Some background IVF is a common infertility treatment in which eggs are stimulated and collected, and fertilized embryos implanted back in the uterus. When IVF embryos...
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In a nutshell This study looked at which factors can predict pregnancy following in vitro fertilization (IVF) for patients with a poor ovarian response (POR). It found that pregnancy was affected by age, body weight, ovarian reserve, and type of fertility medication. Some background For couples with infertility, IVF can greatly increase the chances of...
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In a nutshell This study looked at how the Endometriosis Fertility Index (EFI) affected patients following endometriosis surgery. It found that patients with a better EFI score conceived naturally more often, while more patients with a low score became pregnant using assisted reproduction. Some background Endometriosis is a chronic condition in...
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In a nutshell This study compared two methods of preparing for frozen embryo transfer (FET) for women who do not ovulate regularly. It found that letrozole (Femara) led to fewer miscarriages and higher birth rates than hormone replacement therapy (HRT). Some background FET is an increasingly common infertility treatment. FET uses additional embryos...
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