In a nutshell This study evaluated if there were any clinical indicators to identify which patients with advanced melanoma would benefit from immune checkpoint blocker (ICB) therapy. The data showed that blood LDH levels, the extent of disease, number of white blood cells, and immune-related side effects were all associated with better...
Read More
In a nutshell This study aimed to investigate the effectiveness and safety of combining pembrolizumab (PEM; Keytruda)) and ipilimumab (IPI; Yervoy) for the treatment of advanced-stage melanoma in patients that have progressed after previous PD-1/L1 therapy. The study concluded that this combination was well tolerated and improved the...
Read More
In a nutshell This study investigated which patients with advanced melanoma would benefit the most from a cancer vaccine. The study found that the vaccine was most effective in patients with stage IV melanoma who has surgery to remove the tumor completed all treatment doses. Some background Melanoma is an aggressive type of skin cancer. Treatment...
Read More
In a nutshell This study investigated the effectiveness of dabrafenib (Tafinlar) plus trametinib (Mekinist) treatment before surgery for patients with unresectable advanced-stage melanoma. The data showed that this treatment was effective before surgery and allowed for the removal of tumors. Some background Melanoma is an aggressive type of skin...
Read More
In a nutshell This study described the updates to the National Comprehensive Cancer Network (NCCN) skin melanoma guidelines. Some background Melanoma is one of the most aggressive forms of skin cancer. Patients often have a biopsy of a suspected melanoma to evaluate the severity of the tumor. Treatment for melanoma includes surgery to remove the...
Read More
In a nutshell The aim of this study was to investigate the long-term safety and effectiveness of pembrolizumab (Keytruda) for patients with stage III melanoma that was surgically removed. The study found that patients treated with pembrolizumab were more likely to have an improved outcome. Some background Melanoma is one of the most...
Read More
In a nutshell This study is searching for participants with advanced solid tumors including melanoma to examine the safety and effectiveness of experimental drug avapritinib (Ayvakit). The main outcomes to be measured are the response to treatment and side effects. This trial is being conducted in Texas, US. The details Some cancers grow as a...
Read More
In a nutshell The aim of this study was to evaluate the outcomes of combining stereotactic radiosurgery (SRS) with BRAF inhibitors for brain metastasis in patients with melanoma. The study found that adding BRAF inhibitors to STS improved patient outcomes. Some background Melanoma is one of the most aggressive forms of skin cancer....
Read More
In a nutshell The aim of this study was to evaluate the safety and effectiveness of a cancer vaccine for patients with advanced melanoma. The study found that the vaccine was safe and increased patient survival without worsening of the disease. Some background Treatment for early-stage melanoma includes surgery to remove the tumor. For...
Read More
In a nutshell The aim of this study was to evaluate different types of therapy after surgery for patients with high-risk melanoma. The study found that add-on targeted therapy or immunotherapy was likely to decrease the risk of disease progression in these patients. Some background Melanoma is a form of skin cancer. Treatment for early-stage...
Read More
In a nutshell This study evaluated the safety and effectiveness of nivolumab (Opdivo) in patients with advanced melanoma in a real-world practice. The study found that the safety and effectiveness of nivolumab in these patients were similar to that reported in clinical trials. Some background Melanoma is a form of skin cancer. In more advanced...
Read More
In a nutshell The aim of this study was to evaluate if cell-free circulating tumor DNA (ctDNA) in the blood could predict a patient's response to targeted therapy. The study found that measuring ctDNA could predict how a patient would respond to therapy. Some background Melanoma is a form of skin cancer. Treatment for early-stage...
Read More
