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Melanoma Posts on Medivizor

Dabrafenib combined with trametinib in the treatment of melanoma brain metastasis

Posted by on Aug 21, 2017 in Melanoma | 0 comments

In a nutshell This review examined the effectiveness of dabrafenib (Tafinlar) and trametinib (Mekinist) for BRAF mutated melanoma with brain metastasis. Researchers concluded that this combined treatment is an important therapy option for patients with advanced melanoma. Some background Some melanoma patients have a mutation (permanant change) in...

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Dabrafenib combined with trametinib is associated with durable responses in metastatic melanoma

Posted by on Jun 28, 2017 in Melanoma | 0 comments

In a nutshell This study investigated the effectiveness and safety of combined treatment with dabrafenib (Tafinlar) and trametinib (Mekinist) in patients with BRAF mutated stage 3 or 4 melanoma. Researchers suggested that the combination treatment has durable (3 years or more) results.   Some background Patients with metastatic (spread to...

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Can sentinel lymph node biopsy predict outcome in locally recurrent or in-transit melanomas?

Posted by on Jun 5, 2017 in Melanoma | 0 comments

In a nutshell This study investigated the role of sentinel node biopsy (SLNB) in locally recurrent (LR; when the cancer comes back) melanoma or in-transit (IT; spreads to a lymph vessel before it reaches the nearest lymph node) melanoma. Researchers suggested that SLNB should be performed in these patients. Some background The sentinel lymph node...

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Lactate dehydrogenase is an effective outcome predictive factor for melanoma treatment with PD-1 agents

Posted by on May 16, 2017 in Melanoma | 0 comments

In a nutshell This study investigated whether changes in lactate dehydrogenase (LDH) levels in the blood could predict treatment response to PD-1 agents. Researchers suggested that LDH could be a useful factor to predict treatment outcomes in patients with advanced melanoma.   Some background The use of PD-1 agents to treat melanoma is...

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Carbon-ion radiation therapy is a safe treatment option for head and neck melanomas

Posted by on May 8, 2017 in Melanoma | 0 comments

In a nutshell This study investigated the effectiveness and safety of carbon-ion radiation therapy (CRT) for mucosal melanoma of the head and neck. Researchers suggested that CRT is an important treatment option for these patients. Some background Mucosal head and neck melanomas account for roughly 1% of all melanomas. However, is typically...

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Predictive factors of vulvar melanoma outcomes

Posted by on Mar 25, 2017 in Melanoma | 0 comments

In a nutshell This study investigated the factors predictive of survival of patients with vulvar melanoma (VM). Researchers suggested that tumor thickness and mitotic rate (a measure of how fast cancer cells are dividing and growing) are strong predictors of VM outcomes.  Some background VM affects 1.08 to 1.36 per million women every year in...

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Smoking is associated with an increased risk of melanoma lymph node metastasis

Posted by on Mar 20, 2017 in Melanoma | 0 comments

In a nutshell This study investigated the association between smoking and the risk of melanoma lymph node metastasis (LNM; spread to the lymph nodes). Researchers suggested that smoking is associated with an increase in the risk of LNM in melanoma patients. Some background Smoking is a well-known cause of cancer. However, it does not appear to be...

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