In a nutshell This study was carried out to assess the effectiveness of metastasectomy (ME; surgical removal of tumors that have spread from the original tumor location) for patients with advanced melanoma who responded to targeted or immunotherapy. The authors found that ME for melanoma is associated with a longer overall survival (OS) in...
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In a nutshell This trial is aiming to examine the effectiveness of APG-115 with pembrolizumab (Keytruda) in the treatment of metastatic melanoma. The main outcomes to be measured will be the maximum dose tolerated and the overall response to the drug. This trial is recruiting in multiple locations in the United States. The details...
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In a nutshell This study was carried out to determine whether combination therapy with a standard-dose pembrolizumab (Keytruda) plus reduced-dose ipilimumab (Yervoy) could be used as a treatment option in patients with advanced melanoma. The study found that this combination had good outcomes and manageable side effects in...
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Recent research presented at a virtual meeting of the American Association for Cancer Research 1 indicates the need for greater care and continued social distancing for those who are in treatment for cancer and – in one study that was presented – those who have a recent history of cancer (the research looked at people from 2015 to the...
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In a nutshell The study evaluated whether the combination of atezolizumab (Tecentriq), vemurafenib (Zelboraf), and cobimetinib (Cotellic) or AVC can effectively treat patients with BRAFV600 mutation-positive advanced melanoma (AM). The authors found that this combination was safe and effective as an initial treatment in such...
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In a nutshell The study monitored the occurrence of possible immune-related side effects (irSEs) in patients with advanced melanoma under single and combination therapy of ipilimumab (I; Yervoy), nivolumab (N; Opdivo), and pembrolizumab (P; Keytruda). The authors found that combination therapy increases the frequency of irSEs. Some background...
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In a nutshell This study examined how COVID-19 infection affects patients with cancer undergoing chemotherapy and the role of other factors in COVID-19 complications. The results showed that patients with advanced age and other medical conditions had a higher risk of COVID-19 complications but chemotherapy treatment did not need to be...
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In a nutshell This study examined if biological therapies nivolumab (Opdivo) and ipilimumab (Yervoy) could safely prevent cancer return in patients with stage IV melanoma that has been surgically removed. The results showed that nivolumab and ipilimumab were effective at preventing recurrence but nivolumab alone was safer for patients. Some...
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In a nutshell This study compared the frequency of allergic reactions to different doses of three biological therapies in patients with advanced melanoma. The authors found that different doses of the three drugs reduced the number of allergic reactions. Some background Biological therapy has significantly improved treatment results for patients...
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In a nutshell This article reviewed the skin side effects caused by anti-PD-1 biological therapy. Some background Anti-PD-1 is a type of biological therapy that has significantly improved treatment results for patients with certain types of cancer. It works by blocking PD-1, a molecule that cancer cells use to switch off the immune...
Read MoreIn a nutshell This article reviewed biological therapies for patients with melanoma based on which type of disease they have. Some background Patients with melanoma are often treated with surgery to remove tumors first. In some cases, this is not enough. In other cases, patients have inoperable tumors. These patients are offered...
Read MoreIn a nutshell This study examined if certain immunotherapy drugs increased the risk of developing side effects in the gut in patients with cancer also receiving chemotherapy. The results showed that immunotherapy drugs increased the risks of developing gut-related side effects compared to chemotherapy alone. Some background...
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