In a nutshell This study evaluated CyBorD (cyclophosphamide, bortezomib, dexamethasone) with or without a switch to another regimen mid-treatment for elderly patients with multiple myeloma (MM). The authors concluded that CyBorD was promising for these patients and that switching to VTD chemotherapy during treatment provided better...
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Looking for patients with relapsed or unresponsive multiple myeloma to test a new antibody drug
In a nutshell This study is examining the effectiveness of antibody drug tiragolumab with or without standard treatment for relapsed or unresponsive multiple myeloma or non-Hodgkin lymphoma. The main outcome would be the side effects experienced by patients 1 year after treatment. The details Both multiple myeloma (MM) and non-Hodkin lymphoma...
Read MoreComparison between two standard treatments for transplant-ineligible multiple myeloma
In a nutshell This study investigated whether a combination of bortezomib (Velcade), melphalan (Alkeran) and prednisone (Deltasone) was more effective than lenalidomide (Revlimid) and dexamethasone (Decadron) followed by lenalidomide maintenance for newly diagnosed multiple myeloma (MM). The main finding was that age and disease risk influenced the...
Read MoreLooking for patients with relapsed multiple myeloma to test a biological drug and immune cell vaccine
In a nutshell This trial is investigating the effectiveness and side effects of nivolumab (Opdivo) with a dendritic cell vaccine for patients with multiple myeloma (MM). The main outcome of this study would be to see the number of patients that develop an allergic reaction to the treatment. This study is recruiting in Boston, MA, United...
Read MoreSearching for patients to try combinations of treatments for newly diagnosed multiple myeloma.
In a nutshell This study is looking for patients with newly diagnosed multiple myeloma (MM) to try different treatment regimens. The main outcome that will be measured is the number of patients who do not experience cancer worsening after treatment. This trial is recruiting in Chicago, Illinois, United States. The details There are several...
Read MoreEvaluating strategies to preserve fertility in cancer patients
In a nutshell This study investigated female fertility preservation (FFP) in cancer patients. They found that FFP should be discussed with all women of reproductive age undergoing cancer treatment. Some background Cancer can have many negative effects on patient health. Infertility is a particular concern for younger female patients....
Read MoreCarfilzomib, melphalan and prednisone treatment for newly diagnosed elderly patients with multiple myeloma
In a nutshell This study aimed to investigate the maximum tolerated dose of carfilzomib plus melphalan and prednisone (KMP regimen) in patients with newly diagnosed elderly patients with multiple myeloma (MM). This study concluded that the maximum tolerated dose of carfilzomib was...
Read MoreDoes age influence the safety and effectiveness of stem cell treatment for patients with multiple myeloma?
In a nutshell This study examined the safety and effectiveness of stem cell transplantation (SCT) in elderly patients with multiple myeloma (MM) aged 65 or older compared to younger patients. The authors concluded that SCT was equally as safe and effective for patients in both age groups. Some background Multiple myeloma is a complex type of...
Read MoreCarfilzomib, thalidomide and dexamethasone in the treatment of multiple myeloma
In a nutshell This study looked at the safety and effectiveness of carfilzomib (Kyprolis), thalidomide (Thalomid) and dexamethasone (Decadron) in the treatment of patients with multiple myeloma. Researchers concluded that this treatment plan is safe and effective in these patients. Some background Multiple myeloma is a cancer of the bone marrow. It is...
Read MoreT-cell therapy for relapsed/refractory multiple myeloma
In a nutshell This study aimed to investigate the safety of a T-cell therapy, bb2121, for patients with relapsed or unresponsive multiple myeloma. This study concluded that bb2121 shows antitumor activity in these patients. Some background Early studies indicate that bb2121 has potential to treat relapsed or unresponsive...
Read MoreEvaluating ixazomib maintenance therapy for patients with multiple myeloma
In a nutshell This study evaluated the safety and effectiveness of ixazomib (Ninlaro) maintenance therapy in patients with multiple myeloma (MM). This study concluded that ixazomib is a safe and effective maintenance therapy for these patients. Some background Multiple myeloma is a type of cancer of the bone marrow that can lead to abnormal...
Read MoreNanodrugs
Nanodrugs have been around for some time. In fact, over 250 drugs using nanotechnology that have been approved by the FDA and are in clinical use. The name nanodrug or nanopharmaceuticals refers to the size of the particle that is created to house the medication. A nano is very tiny: nanoparticles are between 1 and 100 nanometers in at least one of its...
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