In a nutshell This study aimed to investigate the impact of venetoclax (Venclexta) modification or early treatment ending on the outcomes of patients with relapsed/refractory chronic lymphocytic leukemia (CLL). This study concluded that venetoclax treatment modification did not impact outcomes but the early ending of...
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In a nutshell This study aimed to compare the outcomes of allogeneic (allo) and autologous (auto) hematopoietic stem cell transplant (HSCT) for patients with acute promyelocytic leukemia (APL) in second complete remission (CR2). This study concluded that autoHSCT resulted in better outcomes for these patients. Some background...
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In a nutshell This study aimed to investigate the long-term survival outcomes of treosulfan (Trecondi)-based versus busulfan (Myleran)-based conditioning treatment in patients with acute myeloid leukemia. This study concluded that treosulfan-based conditioning treatment may have better outcomes for these patients. Some background...
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In a nutshell This study aimed to investigate minimal residual disease (MRD) levels on the outcomes of children with very low-risk (VLR) acute lymphoblastic leukemia (ALL) treated with reduced intensity therapy. This study concluded that patients who had a low level of MRD had good outcomes with reduced intensity...
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In a nutshell This study aimed to investigate the long-term outcomes of nilotinib (Tasigna) versus imatinib (Gleevec) in patients with chronic-phase chronic myeloid leukemia (CP-CML). This study concluded that nilotinib provided good long-term outcomes for these patients. Some background CML results from a gene...
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In a nutshell This study aimed to investigate the effect of tyrosine kinase inhibitor (TKI) dose reduction in patients with chronic myeloid leukemia (CML) after achieving a major molecular response (MMR). This study concluded that the TKI dose reduction was safe and effective for the majority of these...
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In a nutshell This study aimed to investigate the GIMEMA LAL-1308 treatment protocol in young patients with Philadelphia chromosome-negative acute lymphoblastic leukemia. This study concluded that this treatment protocol was safe and effective for these patients. Some background Adolescents and young adults...
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In a nutshell This study aimed to compare the effectiveness of ibrutinib (Imbruvica) to idelalisib (Zydelig)–rituximab (Rituxan) combination for patients with chronic lymphocytic leukemia in a real-life setting. This study concluded that ibrutinib appears to improve survival...
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In a nutshell This study aimed to investigate if chemotherapy (CT) conditioning could replace total body irradiation (TBI) before stem cell transplant (SCT) in children with acute lymphoblastic leukemia (ALL). This study concluded that TBI in combination with CT was safer and more effective than CT conditioning alone in these...
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In a nutshell This study investigated the effectiveness of azacitidine (Onureg) tablets as maintenance therapy in patients with acute myeloid leukemia (AML) in first remission after intensive chemotherapy. The data showed that azacitidine tablets improved the survival of these patients. Some background Acute myelogenous leukemia (AML) is a...
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In a nutshell This study aimed to investigate the combination of dasatinib (Sprycel) and blinatumomab (Blincyto) as a first-line therapy in patients with Philadelphia positive (Ph+) acute lymphoblastic leukemia (ALL). This study concluded that this treatment combination led to better response and survival in these...
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In a nutshell This study aimed to investigate the effect of chemotherapy dose intensity on outcomes for patients with adult T-cell leukemia/lymphoma. This study concluded that higher chemotherapy dose intensity improves outcomes for these patients. Some background Adult T-cell leukemia/lymphoma (ATL) is an aggressive blood cancer. It...
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