In a nutshell The study aimed to identify cardiovascular (heart and blood vessel) adverse drug reactions (CV-ADR) associated with ibrutinib treatment. This study concluded that severe and sometimes fatal cardiac events occur in patients exposed to ibrutinib. Some background Ibrutinib (Imbruvica) is a...
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Is stopping nilotinib treatment safe in patients with chronic myelogenous leukemia that have achieved a stable response?
In a nutshell This study aimed to investigate the safety and effectiveness of stopping nilotinib treatment in patients with chronic-phase chronic myelogenous leukemia. This study concluded that stopping nilotinib after two years of consolidation treatment was safe and effective. Some background...
Read MoreSide effects of ibrutinib treatment in elderly patients with chronic lymphocytic leukemia
In a nutshell This study aimed to compare the side effects associated of ibrutinib treatment for elderly patients with chronic lymphoid leukemia. This study concluded that ibrutinib treatment in these patients was not associated with significantly higher risks of anemia (low red blood cells), thrombocytopenia...
Read MoreAdvances in the management of acute lymphoblastic leukemia
In a nutshell This article aimed to review the advances in the treatment of acute lymphoblastic leukemia in adults. This article concluded that the development of improved treatments has led to better outcomes for these patients. Some background Acute lymphoblastic leukemia (ALL) is an aggressive...
Read MoreStem cell transplant in patients in second complete remission with core binding factor acute myeloid leukemia.
In a nutshell This study aimed to investigate the outcomes of allogeneic transplantation in patients with core-binding factor acute myeloid leukemia in second complete remission. This study concluded that transplant was effective in a large proportion of these patients. Some background Core binding factor acute myeloid...
Read MoreSearching for patients with different types of leukemia to test modified stem cell transplants donated by relatives
In a nutshell This trial is examining the effectiveness of modified stem cell transplants (SCT) donated by patient relatives, which have certain immune cells removed to prevent transplant rejection in patients with leukemia and lymphoma. The main outcome will be the maximum dose of SCT that can be given safely and is effective. This study is recruiting...
Read MoreDecitabine, cytarabine and umbilical cord blood infusion as consolidation therapy for elderly patients with acute myeloid leukemia
In a nutshell This study aimed to investigate the combination of low-dose decitabine, medium-dose cytarabine and umbilical cord blood infusion as a consolidation therapy for elderly patients with acute myeloid leukemia. This study concluded that this treatment combination was effective in these patients. Some...
Read MoreInotuzumab ozogamicin treatment for patients with acute lymphoblastic leukemia and the burden of hospitalization
In a nutshell This study aimed to investigate if treatment with inotuzumab ozogamicin in patients with relapsed/unresponsive acute lymphoblastic leukemia was associated with lower healthcare system burden compared to standard of care. This study...
Read MoreSurviving cancer – is there a greater risk of cardiovascular disease long-term?
In a nutshell This study investigated if there is a higher risk of cardiovascular disease (CVD) in cancer survivors. They found that cancer survivors have a higher risk of CVD. Some background Improved cancer detection and treatment has increased the rates of survival. The number of cancer survivors living for more than 10 years is growing. Some...
Read MoreEvaluating the TLI-ATG conditioning regimen before allogeneic stem cell transplantation in patients with lymphoma or leukemia
In a nutshell This study evaluated the safety and effectiveness of total lymphoid irradiation and anti-thymocyte globulin (TLI-ATG) conditioning before stem cell transplantation (SCT) in patients with lymphoma or leukemia. This study concluded that this regimen was well-tolerated and effective, especially for patients who had multiple lines of prior...
Read MoreFertility options for female patients with lymphoma or leukemia
In a nutshell This article reviewed different options to preserve or restore fertility in female patients with lymphoma or leukemia. Some background Impaired reproductive function is one possible side effect of aggressive chemotherapy and radiotherapy for cancer. In severe cases, intensive anti-cancer treatment can lead to fertility loss. 7 to 9% of...
Read MoreStem cell transplant after blinatumomab in patients with relapsed or unresponsive acute lymphoblastic leukemia
In a nutshell This study aimed to investigate the outcomes for patients who underwent allogeneic hematopoietic stem cell transplant after treatment with blinatumomab. This study concluded that survival was driven by the response to study treatment and by salvage status regardless of transplant status. Some...
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