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Dasatinib and decitabine treatment for patients with accelerated or blast phase chronic myeloid leukemia

Dasatinib and decitabine treatment for patients with accelerated or blast phase chronic myeloid leukemia

Posted by on Sep 17, 2020 in Leukemia | 0 comments

In a nutshell This study aimed to investigate if the combination of dasatinib and decitabine was safe and effective in patients with advanced chronic myeloid leukemia.   This study concluded that this treatment is safe and effective in these patients.   Some background Treatment of advanced-phase chronic myeloid...

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The effects of ofatumumab in combination with chemotherapy in patients with (Ph)-negative B-cell acute lymphoblastic leukemia

The effects of ofatumumab in combination with chemotherapy in patients with (Ph)-negative B-cell acute lymphoblastic leukemia

Posted by on Sep 11, 2020 in Leukemia | 0 comments

In a nutshell The study evaluated outcomes of combining ofatumumab (Arzerra) with hyper-CVAD chemotherapy in patients with Philadelphia chromosome (Ph)-negative CD20-positive B-cell acute lymphoblastic leukemia (B-ALL). The authors found that the combination was safe and effective in such patients. Some background Philadelphia chromosome (Ph) is a...

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Treating acute myeloid leukemia with FLT3-ITD mutation by sorafenib maintenance after HSCT

Treating acute myeloid leukemia with FLT3-ITD mutation by sorafenib maintenance after HSCT

Posted by on Aug 23, 2020 in Leukemia | 0 comments

In a nutshell The study evaluated outcomes of sorafenib (Nexavar) maintenance therapy after allogeneic hematopoietic stem cell transplantation (alloHSCT) in patients with acute myeloid leukemia (AML) carrying FLT3-ITD mutation. The authors found that sorafenib maintenance therapy decreased the risks of relapse and mortality after HSCT in such...

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Does donor type impact on outcomes of stem cell transplant for very high-risk acute lymphoblastic leukemia pediatric patients?

Does donor type impact on outcomes of stem cell transplant for very high-risk acute lymphoblastic leukemia pediatric patients?

Posted by on Aug 23, 2020 in Leukemia | 0 comments

In a nutshell This study aimed to investigate if donor type impacts on the overall outcomes of allogeneic stem cell transplant for children with very high-risk acute lymphoblastic leukemia.   This study concluded that donor type does impact on these patients and that worse outcomes are seen with mismatched donors.   Some...

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Risk-stratified therapy and the impact on long-term toxicity in patients with childhood acute lymphoblastic leukemia

Risk-stratified therapy and the impact on long-term toxicity in patients with childhood acute lymphoblastic leukemia

Posted by on Aug 20, 2020 in Leukemia | 0 comments

In a nutshell This study aimed to investigate the impact of risk-stratified therapy on long-term toxicity in patients with childhood acute lymphoblastic leukemia.   This study concluded that risk-stratified therapy has reduced late complications and mortality among survivors of standard-risk acute lymphoblastic leukemia.  Some background...

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Evaluating antithymocyte globulin in preventing graft-versus-host-disease after matched sibling donor transplantation

Evaluating antithymocyte globulin in preventing graft-versus-host-disease after matched sibling donor transplantation

Posted by on Aug 16, 2020 in Leukemia | 0 comments

In a nutshell This study aimed to investigate the role of antithymocyte globulin in preventing graft-versus-host disease after matched sibling donor transplantation.  This study concluded that this treatment can reduce the occurrence of graft-versus-host-disease in these patients.   Some background One...

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