In a nutshell This study aimed to investigate the effectiveness of interferon-alpha (IFN-α) in acute leukemia patients with minimal residual disease after stem cell transplantation. This study concluded that IFN-α is an effective treatment for acute leukemia patients with minimal residual disease after stem cell...
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What effect does smoking have on chronic myeloid leukemia patients?
In a nutshell This study aimed to investigate the impact of smoking on survival and progression of disease in patients with chronic myeloid leukemia. This study concluded that smoking has a negative impact on survival and progression of disease in patients with chronic myeloid leukemia. Some background Chronic myeloid leukaemia (CML)...
Read MoreWhat are the side effects of ibrutinib treatment for chronic lymphocytic leukemia?
In a nutshell This study aimed to investigate atrial fibrillation as a side effect of ibrutinib (imbruvica) in chronic lymphocytic leukemia. This study concluded that atrial fibrillation is a common side effect associated with ibrutinib use in patients with chronic lymphocytic leukemia. Some background Chronic lymphocytic leukemia (CLL)...
Read MoreOutcomes for patients with relapsed or refractory acute leukemia receiving donor lymphocyte infusions after stem cell transplant
In a nutshell This study examined whether donor lymphocyte infusion (DLI) can reduce the risk of relapse after stem cell transplantation in patients with relapsed or refractory acute leukemia. Researchers reported improved outcomes among patients receiving multiple DLIs guided by the presence of minimal residual disease or graft-versus-host...
Read MoreTargeted therapies: Ibrutinib appears superior to idelalisib as first treatment
In a nutshell This study examined the order of treatment with ibrutinib (Imbruvica), idelalisib (Zydelig), and venetoclax (ABT-199) for chronic lymphocytic leukemia (CLL). Researchers concluded that ibrutinib appears superior to idelalisib as first treatment. Some background Early studies are reporting promising results with targeted therapies for...
Read MoreIs there a benefit of reduced-intensity conditioning plus imatinib compared to imatinib alone?
In a nutshell This study examined two types of treatment regimes involving imatinib (Gleevac) for chronic myeloid leukemia (CML). Patients receiving reduced-intensity chemotherapy and a stem cell transplant before imatinib had similar outcomes to patients treated with imatinib alone. Some background Targeted therapy has become the standard...
Read MoreImatinib is safe and effective for long-term CML treatment
In a nutshell This study examined the results of a 10 year imatinib (Gleevec) clinical trial. The study concluded that imatinib is a safe and effective treatment for CML. Some background Chronic myeloid leukemia (CML) is a disease in which the bone marrow makes too many mature and immature white blood cells. CML is a slowly progressing blood and...
Read MoreIs hematopoietic cell transplantation a good option for those with primary acute lymphoblastic leukemia that has not responded to treatment?
In a nutshell This study aimed to investigate the outcomes of hematopoietic cell transplantation for primary refractory acute lymphoblastic leukemia. This study concluded that hematopoietic cell transplantation is of benefit to patients with primary refractory acute lymphoblastic leukemia. Some background Acute lymphoblastic leukemia (ALL)...
Read MoreAn overview of treatment options for older AML patients
In a nutshell This study reviewed treatment strategies for older patients with acute myeloid leukemia (AML). Some background AML is a cancer of the blood and bone marrow that mainly affects the elderly. The average age at diagnosis is 67 years. While advances in AML treatment have increased survival, outcomes for the elderly remain...
Read MoreTreatment advances for relapsed or refractory chronic lymphocytic leukemia
In a nutshell This paper reviewed advances in treatment options for relapsed and refractory chronic lymphocytic leukemia. Some background Chronic lymphocytic leukemia (CLL) is a cancer of the blood and blood forming cells. Despite a good response to initial therapy, most patients relapse and require further treatment. Some patients may stop...
Read MoreEffectiveness and safety of nilotinib in chronic phase chronic myeloid leukemia
In a nutshell This study examined the effectiveness of different doses of nilotinib (Tasigna) in patients with newly diagnosed chronic myeloid leukemia in chronic phase. This study concluded that nilotinib was safe and effective in treating chronic myeloid leukemia. Some background Chronic myeloid leukemia is a cancer where the...
Read MoreRemaining leukemia cells have a negative impact on stem cell transplantation in AML
In a nutshell This study looked at the effect of remaining leukemia cells (present in bone marrow during remission) on stem cell transplant outcomes in acute myeloid leukemia patients. The study concluded that the presence of leukemia cells prior to stem cell transplantation has a negative effect on patient outcomes. Some background Adult...
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