In a nutshell This study aimed to investigate if the combination of dasatinib and decitabine was safe and effective in patients with advanced chronic myeloid leukemia. This study concluded that this treatment is safe and effective in these patients. Some background Treatment of advanced-phase chronic myeloid...
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In a nutshell This study aimed to investigate the safety and effectiveness of the combination of obinutuzumab (Gazyva), ibrutinib (Imbruvica) and venetoclax (Venclexta) in patients with chronic lymphocytic leukemia. This study concluded that this treatment is safe and effective for these patients. Some...
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In a nutshell This study aimed to investigate if postinduction central nervous system (CNS; brain and spine) protection with intrathecal (injection into the spine) triple therapy (ITT) would improve the outcomes for pediatric patients with acute lymphoblastic leukemia (ALL) when compared to intrathecal methotrexate (MTX; Otrexup)...
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In a nutshell The study evaluated outcomes of combining ofatumumab (Arzerra) with hyper-CVAD chemotherapy in patients with Philadelphia chromosome (Ph)-negative CD20-positive B-cell acute lymphoblastic leukemia (B-ALL). The authors found that the combination was safe and effective in such patients. Some background Philadelphia chromosome (Ph) is a...
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In a nutshell This study aimed to investigate treatment outcomes with transplant and tyrosine kinase inhibitors for childhood chronic myeloid leukemia. This study concluded that some tyrosine kinase inhibitors provide better outcomes for these patients. Some background Chronic myeloid leukemia (CML) is a rare disease in childhood....
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In a nutshell This study aimed to investigate if venetoclax and intense chemotherapy is a safe and effective treatment in older patients with acute myeloid leukemia. This study concluded that this treatment was safe and effective in these patients. Some background Venetoclax (Venclexta) is a...
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In a nutshell The study evaluated outcomes of sorafenib (Nexavar) maintenance therapy after allogeneic hematopoietic stem cell transplantation (alloHSCT) in patients with acute myeloid leukemia (AML) carrying FLT3-ITD mutation. The authors found that sorafenib maintenance therapy decreased the risks of relapse and mortality after HSCT in such...
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In a nutshell This study aimed to investigate the outcomes and side effects of ibrutinib in patients with chronic lymphocytic leukemia in the real-world setting. This study concluded that the outcomes for these patients in the real-world setting were similar to clinical trials but the rate of side...
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In a nutshell This study aimed to investigate if donor type impacts on the overall outcomes of allogeneic stem cell transplant for children with very high-risk acute lymphoblastic leukemia. This study concluded that donor type does impact on these patients and that worse outcomes are seen with mismatched donors. Some...
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In a nutshell This study aimed to investigate the impact of risk-stratified therapy on long-term toxicity in patients with childhood acute lymphoblastic leukemia. This study concluded that risk-stratified therapy has reduced late complications and mortality among survivors of standard-risk acute lymphoblastic leukemia. Some background...
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In a nutshell This study aimed to investigate the role of antithymocyte globulin in preventing graft-versus-host disease after matched sibling donor transplantation. This study concluded that this treatment can reduce the occurrence of graft-versus-host-disease in these patients. Some background One...
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In a nutshell This study aimed to investigate treatment-free remission in patients with chronic myeloid leukemia. This study concluded that some patients can experience late relapses and that long term follow-up is mandatory for these patients. Some background Treatment-free remission (TFR) can be used in patients with chronic myeloid...
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