In a nutshell This study aimed to investigate the effectiveness of venetoclax (Venclexta) and rituximab (Rituxan) treatment in patients with relapsed/refractory chronic lymphocytic leukemia. This study concluded that venetoclax-rituximab treatment was effective for these patients. Some background Chronic lymphocytic leukemia...
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Switching from imatinib to dasatinib for chronic phase chronic myelogenous leukemia patients
In a nutshell This study aimed to investigate if side effects of imatinib (Gleevec) treatment in chronic phase chronic myelogenous leukemia would improve if patients were switched to dasatinib (Sprycel) treatment. This study concluded that these patients experience improvements in side effects and quality of life once they switch treatment. Some...
Read MoreComparing conditioning regimens for adult patients with Ph-negative acute lymphoblastic leukemia treated with stem cell transplant
In a nutshell This study aimed to compare two conditioning treatment regimens for adult patients with Ph-negative acute lymphoblastic leukemia treated with stem cell transplant. This study concluded that the regimen that combined etoposide (Etopophos) and total body irradiation was more effective than the regimen that combined cyclophosphamide (Neosar)...
Read MoreHow safe and effective is ponatinib for chronic phase chronic myeloid leukemia patients?
In a nutshell This study aimed to investigate the effectiveness and safety of ponatinib (Iclusig) for patients with chronic phase chronic myelogenous leukemia. This study concluded that ponatinib is safe and effective in this group of patients. Some background The Philadelphia chromosome (BCR-ABL1) is found in almost all patients with chronic...
Read MoreTreatment options for chronic myeloid leukemia patients with failed imatinib treatment
In a nutshell This study aimed to investigate the safety and effectiveness of dasatinib (Sprycel) and nilotinib (Tasigna) in chronic phase chronic myeloid leukemia patients with failed imatinib (Gleevec) treatment. This study concluded that dasatinib and nilotinib were safe and effective in this group of patients. Some background Chronic...
Read MorePediatric-inspired therapy vs non-intensive therapy in Ph-negative acute lymphoblastic leukemia patients aged 55-65 years
In a nutshell This study aimed to compare pediatric-inspired intensive therapy and non-intensive therapy for older patients with acute lymphoblastic leukemia. This study concluded that pediatric-inspired intensive therapy improves the outcome for these patients when compared to the non-intensive therapy. Some background Acute lymphoblastic leukemia...
Read MoreDefining therapy goals for major molecular remission in chronic myeloid leukemia patients
In a nutshell This study aimed to define therapy goals for major molecular remission in chronic myeloid leukemia. This study concluded that the optimal time for major molecular remission was 12-15 months and if not achieved at this point a change in treatment is needed. Some background Major molecular remission (MMR) is an important therapy goal in...
Read MoreHow safe is long-term ibrutinib for chronic lymphocytic leukemia patients?
In a nutshell This study aimed to investigate the safety and effectiveness of ibrutinib (Imbruvica) in chronic lymphocytic leukemia. This study concluded that long-term administration of ibrutinib was well tolerated and provided effective disease control for most patients. Some background Ibrutinib is a targeted therapy that can be used for...
Read MoreTreatment for acute myeloid leukemia patients involving thiotepa and stem cell transplant.
In a nutshell This study aimed to investigate the use of stem cell transplant with a chemotherapy treatment regime in patients with acute myeloid leukemia. This study concluded that this regime is safe and effective in patients that receive stem cell transplants from a haploidentical (half or partially matched) donor. Some background The use of...
Read MoreA new option for chronic myeloid leukemia patients who have an intolerance to TKIs
In a nutshell This study aimed to investigate the safety and effectiveness of nilotinib (Tasigna) in patients with chronic phase chronic myeloid leukemia who have an intolerance to other tyrosine kinase inhibitors. This study concluded that this group of patients can be treated with nilotinib and it can lead to deep molecular responses. Some background...
Read MoreRisk factors that influence outcomes for acute leukemia patients with relapse after hematopoietic stem cell transplant.
In a nutshell This study aimed to investigate risk factors that influence the outcome of acute leukemia patients who experience relapse after hematopoietic stem cell transplant. This study concluded that certain factors, such as older age and not acheiving remission after relapse treatment, are associated with worse survival outcomes. Some...
Read More5 Things You Probably Didn’t Know About Your Adrenal Glands
The adrenal glands-which are also called suprarenal glands-are part of the endocrine system and are found on the top of each kidney. How the endocrine system hormones work Hormones secreted from glands of the endocrine system travel in the bloodstream to target cells. Target cells have receptors that are specific to each hormone. The hormones and receptors...
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