In a nutshell This study investigated the occurrence of graft-versus-host disease (GVHD) in pediatric patients who underwent an allogeneic stem cell transplant (alloSCT). This study concluded that both umbilical cord blood cells and bone marrow cells led to similar rates of GVHD in children with acute leukemia. Some background Allogeneic stem cell...
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Looking for patients with Ph+ or BCR-ABL+ acute lymphoblastic leukemia to test a treatment combination
In a nutshell This phase 2 trial is evaluating the effectiveness of ponatinib (Iclusig) plus chemotherapy for patients with acute lymphoblastic leukemia (ALL) that is positive for the Philadelphia chromosome (Ph+) or the BCR-ABL gene (BCR-ABL+). The main outcome to be measured will be the number of patients who respond to treatment. This study is...
Read MoreLooking for older patients with acute myeloid leukemia to test a new treatment combination
In a nutshell This study is evaluating how well CPI-613 plus chemotherapy works in older patients with acute myeloid leukemia (AML) that has come back or stopped responding to treatment. The main outcome to be measured will be the number of patients who have a complete disappearance of all signs of cancer. This trial is taking place across the United...
Read MoreOutcomes of stem cell transplant for patients with acute lymphoblastic leukemia after inotuzumab ozogamicin treatment
In a nutshell This study aimed to investigate the outcomes of allogeneic stem cell transplant (allo-SCT) after treatment with inotuzumab ozogamicin (Besponsa) for patients with relapsed/unresponsive acute lymphoblastic leukemia (ALL). This study concluded that allo-SCT provided optimal long-term survival benefit for these patients. Some...
Read MoreInfection rates in children with acute lymphoblastic leukemia who receive stem-cell transplant from unrelated donors
In a nutshell This study aimed to investigate infection rates in children with acute lymphoblastic leukemia who received stem cell transplant from unrelated donors. This study concluded that these patients experience higher infection rates than other patients. Some background Allogeneic hematopoietic stem cell transplantation...
Read MoreComparing frontline therapies in older patients with acute myeloid leukemia
In a nutshell This study aimed to compare frontline therapies in older patients with acute myeloid leukemia. This study concluded that hypomethylating agents provided better overall survival for these patients. Some background Older patients with acute myeloid leukemia (AML), more frequently...
Read MoreComparing post remission therapies in older patients with acute myeloid leukemia
In a nutshell This study aimed to compare post-remission therapies for older patients with acute myeloid leukemia who are in complete remission. This study concluded that stem cell transplantation is more effective as a post-remission therapy than consolidation chemotherapy, but with more risks early-on. Some background...
Read MoreDetermining predictors of long-term survival in imatinib-treated chronic myeloid leukemia
In a nutshell This study aimed to determine potential predictors of long-term survival in patients with chronic myeloid leukemia (CML) treated with imatinib. This study concluded that phase at diagnosis and blood-cells response at 3 months were potential predictors of long-term survival in these patients. Some background Imatinib...
Read MoreLong term outcomes of imatinib treatment for chronic myeloid leukemia
In a nutshell This study aimed to investigate the long-term outcomes of imatinib treatment in patients with CML. This study concluded that imatinib is safe and effective for long periods of use. Some background Imatinib (Gleevec) is a tyrosine kinase inhibitor (TKI) approved for the treatment of chronic myeloid leukemia (CML). TKIs...
Read MoreLooking for patients to try a treatment combination for untreated chronic lymphocytic leukemia.
In a nutshell This study is searching for patients with previously untreated chronic lymphocytic leukemia (CLL) to try a new treatment combination containing obinutuzumab (Gazyva) or obinutuzumab/bendamustine (Treanda) to shrink the tumor (debulking) before treatment with venetoclax (Venclexta). The main outcome that will be measured is the number...
Read MoreEvaluating first-line imatinib for elderly patients with chronic myeloid leukemia
In a nutshell This study compared the effects of age and treatment dose for imatinib (Gleevec) in elderly versus younger patients with chronic myeloid leukemia (CML). This study concluded older patients had similar responses to therapy compared to younger patients. Some background Tyrosine kinase (TK) inhibitors are the standard therapy for chronic...
Read MoreEvaluating the risk of heart side effects of bosutinib in patients with chronic myeloid leukemia
In a nutshell This study evaluated the effects of bosutinib (Bosulif) on the heart in patients with chronic myeloid leukemia (CML). This study concluded that bosutinib was associated with heart-related side effects, particularly in high-risk patients. Some background Previous studies have shown that bosutinib is effective and well-tolerated. However,...
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