In a nutshell This study examined the safety and effectiveness of using nilotinib (Tasigna) in patients with chronic myeloid leukemia (CML) unresponsive to other treatment. The study concluded that nilotinib is safe and effective in the treatment of CML unresponsive to imatinib (Gleevec). Some background Chronic myeloid leukemia is a cancer of the...
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What is the evidence for and against green tea and tumeric in the management of CLL?
In a nutshell This study looked at the evidence for and against green tea and turmeric in the treatment of chronic lymphocytic leukemia (CLL). The study found that there is a lack of evidence of these treatments in treating CLL. Some background Complementary alternative medicine (CAM) are a commonly used group of practices and products that are...
Read MoreOutcomes and management of CLL treated with venetoclax
In a nutshell This study examined the safety and effectiveness of venetoclax (Venclexta) in the treatment of chronic lymphocytic leukemia (CLL). Researchers found that venetoclax was safe and effective in these patients. Some background Chronic lymphocytic leukemia is a type of cancer of the bone marrow that can lead to an abnormal immune system. Over...
Read MoreInvestigating bone loss in adult patients with lymphoma or leukemia
In a nutshell This study investigated the occurrence and impact of bone loss in adult patients with lymphoma and leukemia. This study concluded that these patients have significant bone loss compared to the general population. Some background Bone loss is a known consequence of many cancers and their treatments. In healthy adults, bone loss is...
Read MoreEvaluating vascular safety of TK inhibitors in patients with chronic myeloid leukemia
In a nutshell This study investigated the vascular (blood vessels) side effects associated with tyrosine kinase inhibitors in patients with chronic myeloid leukemia (CML). This study concluded that patients treated with nilotinib (Tasigna) experienced more vascular side effects. Some background Tyrosine kinase (TK) inhibitors are the standard therapy...
Read MoreOutcomes of salvage therapy for patients with chronic lymphocytic leukemia
In a nutshell This study aimed to investigate outcomes of salvage therapy after treatment with fludarabine, cyclophosphamidine and rituximab fails in patients with chronic lymphocytic leukemia. This study concluded that salvage therapy can provide excellent outcomes for these patients. Some background Fludarabine (Fludara) is a chemotherapy used...
Read MoreNilotinib versus imatinib in the treatment of CML
In a nutshell This study compared the effectiveness of nilotinib (Tasigna) with high-dose imatinib (Glivec) in patients with unresponsive chronic myeloid leukemia. Researchers concluded that nilotinib may be more effective as a long-term treatment for CML when compared to imatinib. Some background Chronic myeloid leukemia is a cancer of the bone...
Read MoreMonitoring BCR-ABL1 levels in chronic myeloid leukemia patients
In a nutshell This study aimed to investigate the benefits of monitoring early molecular response markers for chronic myeloid leukemia. This study concluded that monitoring BCR-ABL1 values at an early stage could help with assessing response and making decisions regarding timing of treatments. Some background Measuring molecular response markers...
Read MoreWhat major factors affect disease progression and outcome in adults with acute myeloid leukemia?
In a nutshell This study examined the major factors associated with disease progression and outcomes in adults with acute myeloid leukemia (AML). The authors found that younger age, less molecular mutations and choice of induction therapy were all positively associated with higher rates of complete remission and survival. Some background A number...
Read MoreOverall survival and relapse rate in adults with AML who have received a stem cell transplant from a donor
In a nutshell This study aimed to identify the outcomes and prognostic factors following a stem cell transplant from a donor in adults with acute myeloid leukemia in their second complete remission (no sign of disease). The authors determined that this type of transplant was effective in these patients. Some background In adult patients with acute...
Read MoreObinutuzumab treatment for patients with chronic lymphocytic leukemia
In a nutshell This study aimed to investigate the safety of obinutuzumab (Gazyva) in a range of patients with chronic lymphocytic leukemia. This study concluded that obinutuzumab is safe and tolerable for a range of patients with chronic lymphocytic leukemia. Some background Obinutuzumab is a targeted therapy for chronic lymphocytic...
Read MoreTreatment plans for children with Philadelphia chromosome positive ALL
In a nutshell This study aimed to assess treatment plans and outcomes in children with acute lymphoblastic leukemia and genetic abnormalities in the Philadelphia chromosome (Ph-positive). The study concluded that adding imatinib (Gleevec) to intensive chemotherapy may be an effective treatment for these patients. Some background Acute lymphoblastic...
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