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Leukemia Posts on Medivizor

Graft-versus-host disease in pediatric patients with acute leukemia after alloSCT

Posted by on Jun 16, 2019 in Leukemia | 0 comments

In a nutshell This study investigated the occurrence of graft-versus-host disease (GVHD) in pediatric patients who underwent an allogeneic stem cell transplant (alloSCT). This study concluded that both umbilical cord blood cells and bone marrow cells led to similar rates of GVHD in children with acute leukemia. Some background Allogeneic stem cell...

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Looking for patients with Ph+ or BCR-ABL+ acute lymphoblastic leukemia to test a treatment combination

Posted by on Jun 14, 2019 in Leukemia | 0 comments

In a nutshell This phase 2 trial is evaluating the effectiveness of ponatinib (Iclusig) plus chemotherapy for patients with acute lymphoblastic leukemia (ALL) that is positive for the Philadelphia chromosome (Ph+) or the BCR-ABL gene (BCR-ABL+). The main outcome to be measured will be the number of patients who respond to treatment. This study is...

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Looking for older patients with acute myeloid leukemia to test a new treatment combination

Posted by on Jun 14, 2019 in Leukemia | 0 comments

In a nutshell This study is evaluating how well CPI-613 plus chemotherapy works in older patients with acute myeloid leukemia (AML) that has come back or stopped responding to treatment. The main outcome to be measured will be the number of patients who have a complete disappearance of all signs of cancer. This trial is taking place across the United...

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Outcomes of stem cell transplant for patients with acute lymphoblastic leukemia after inotuzumab ozogamicin treatment

Posted by on Jun 5, 2019 in Leukemia | 0 comments

In a nutshell This study aimed to investigate the outcomes of allogeneic stem cell transplant (allo-SCT) after treatment with inotuzumab ozogamicin (Besponsa) for patients with relapsed/unresponsive acute lymphoblastic leukemia (ALL). This study concluded that allo-SCT provided optimal long-term survival benefit for these patients. Some...

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Infection rates in children with acute lymphoblastic leukemia who receive stem-cell transplant from unrelated donors

Posted by on Jun 5, 2019 in Leukemia | 0 comments

In a nutshell This study aimed to investigate infection rates in children with acute lymphoblastic leukemia who received stem cell transplant from unrelated donors.  This study concluded that these patients experience higher infection rates than other patients.   Some background Allogeneic hematopoietic stem cell transplantation...

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Determining predictors of long-term survival in imatinib-treated chronic myeloid leukemia

Posted by on May 31, 2019 in Leukemia | 0 comments

In a nutshell This study aimed to determine potential predictors of long-term survival in patients with chronic myeloid leukemia (CML) treated with imatinib.   This study concluded that phase at diagnosis and blood-cells response at 3 months were potential predictors of long-term survival in these patients.  Some background Imatinib...

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Looking for patients to try a treatment combination for untreated chronic lymphocytic leukemia.

Posted by on May 28, 2019 in Leukemia | 0 comments

In a nutshell This study is searching for patients with previously untreated chronic lymphocytic leukemia (CLL) to try a new treatment combination containing obinutuzumab (Gazyva) or obinutuzumab/bendamustine (Treanda) to shrink the tumor (debulking) before treatment with venetoclax (Venclexta). The main outcome that will be measured is the number...

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Evaluating first-line imatinib for elderly patients with chronic myeloid leukemia

Posted by on May 28, 2019 in Leukemia | 0 comments

In a nutshell This study compared the effects of age and treatment dose for imatinib (Gleevec) in elderly versus younger patients with chronic myeloid leukemia (CML). This study concluded older patients had similar responses to therapy compared to younger patients. Some background Tyrosine kinase (TK) inhibitors are the standard therapy for chronic...

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Evaluating the risk of heart side effects of bosutinib in patients with chronic myeloid leukemia

Posted by on May 26, 2019 in Leukemia | 0 comments

In a nutshell This study evaluated the effects of bosutinib (Bosulif) on the heart in patients with chronic myeloid leukemia (CML). This study concluded that bosutinib was associated with heart-related side effects, particularly in high-risk patients. Some background Previous studies have shown that bosutinib is effective and well-tolerated. However,...

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