In a nutshell This review discussed the treatment options for older adults with chronic lymphocytic leukemia. This article recommends that CLL patients should have a fitness test before starting treatments to determine which treatment would suit them best. Some background Chronic lymphocytic leukemia (CLL) is a blood and bone marrow disease....
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Childhood chronic myeloid leukemia – impact of rare genetic changes
In a nutshell This study examined whether the presence of certain genetic changes had an impact on the rate of survival of children with chronic myeloid leukemia. Some background Chronic myeloid leukemia (CML) is a disease in which the bone marrow makes too many mature and immature white blood cells. CML is a slowly progressing blood...
Read MoreAdding pioglitazone to imatinib in chronic myeloid leukemia
In a nutshell This paper studied the use of pioglitazone (Actos) with imatinib (Gleevec) in patients with chronic myeloid leukemia (CML). The authors concluded that the addition of pioglitazone improved response. Some background Chronic myeloid leukemia is a cancer of the bone marrow, where there is an excess of...
Read MoreClassifying risk groups based on genetics in children with ALL
In a nutshell This study examined genetic changes in children with acute lymphoblastic leukemia (ALL). Researchers concluded that chromosomal abnormalities and specific gene deletions can reliably predict treatment outcomes. Some background ALL is a cancer of the blood and bone marrow. It is the most common type of childhood cancer. Using...
Read MoreLong-term remission rates after treatment with second-generation tyrosine kinase inhibitors
In a nutshell This study examined long-term remission rates after treatment with second-generation tyrosine kinase inhibitors (TKIs) for chronic myeloid leukemia (CML). Researchers reported that second-generation TKIs can achieve lasting remission rates up to 48 months after the end of treatment. Some background Targeted therapy is the standard...
Read MoreHodgkin lymphoma related to chronic lymphocytic leukemia (Richter syndrome)
In a nutshell This study examined chronic lymphocytic leukemia that develops into Hodgkin lymphoma (Richter syndrome). The study concluded that chronic lymphocytic leukemia-related Hodgkin lymphoma can be treated with ABVD chemotherapy. Some background Chronic lymphocytic leukemia (CLL) is a type of cancer that affects white blood cells and...
Read MoreStem cell transplantation in chronic myeloid leukemia
In a nutshell This review discussed the role of stem cell transplantation in patients with chronic myeloid leukemia. Some background Stem cell (immature blood cell) transplantation (SCT) has had a long history in the treatment of chronic myeloid leukemia (CML). Patients who have a matched donor (someone who is a close genetic match, such as a...
Read MoreStem cell transplantation: Minimal residual disease response as a predictors of success
In a nutshell This study examined the role of stem cell transplantation in adult acute lymphoblastic leukemia (ALL) patients treated with pediatric-inspired chemotherapy. The study also explored whether minimal residual disease could help to predict which patients would benefit from stem cell transplant. Researchers reported that early minimal residual...
Read MoreCurrent treatment practices for childhood ALL
In a nutshell This study examined evidence on treatment practices for childhood acute lymphoblastic leukemia (ALL). Some background ALL is a type of cancer in which the bone marrow makes too many lymphoblasts (a type of immature white blood cell). It is the most common type of childhood cancer. Advances in risk classification, supportive care, and...
Read MoreIs lower-intensity chemotherapy effective before stem cell transplantation?
In a nutshell This study investigated the effectiveness of reduced intensity conditioning (RIC) before stem cell transplantation (SCT) in acute myeloid leukemia (AML). This study concluded that in the long-term RIC was as effective as more intense myeloablative conditioning (MAC). Some background Allogeneic SCT (transplant of immature blood cells...
Read MoreUnrelated umbilical cord blood as a valid alternative source for stem cell transplantation
In a nutshell This study examined different sources of allogenic (donor) stem cell transplantation for adult acute lymphoblastic leukemia (ALL) patients who are in first or second remission. Researchers reported no significant differences in survival across allogenic stem cell sources. In the absence of a matched related or unrelated adult donor,...
Read MoreExamining long-term treatment outcomes in patients with T-cell ALL
In a nutshell This study examined treatment outcomes in patients with T-cell acute lymphoblastic leukemia (T-ALL). Researchers reported that certain subgroups of T-ALL patients, such as those with specific genetic changes, affected long-term survival. More studies are needed to confirm these preliminary results. Some background T-cell acute...
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