In a nutshell This study aimed to investigate the rate of deep molecular response in patients with newly diagnosed chronic myeloid leukemia who were treated with nilotinib. This study concluded that good molecular response rates are seen in these patients. Some background Molecular response (MR) is a measure of the levels of BCR-ABL1 gene in leukemia...
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Combining pracinostat and azacitidine to treat older patients with newly diagnosed acute myeloid leukemia
In a nutshell This study aimed to investigate the safety and effectiveness of the combination of pracinostat and azacitidine in patients aged over 65 with newly diagnosed acute myeloid leukemia. This study concluded that this combination is a safe and effective for treating this group of patients. Some background Pracinostat is a new drug that...
Read MoreHeart-related side effects of tyrosine kinase inhibitors in chronic myeloid leukemia
In a nutshell This study aimed to investigate the risk of cardiovascular (heart and blood vessel) side effects in patients with chronic myeloid leukemia who were treated with tyrosine kinase inhibitors. This study concluded that these side effects were more frequent in this group of patients. Some background Cardiovascular events (CVE) have been...
Read MoreThe impact of graft-versus-lymphoma effect on outcomes after reduced intensity conditioned stem cell transplant
In a nutshell This study aimed to investigate the impact of the graft-versus-lymphoma effect on the outcomes for patients with leukemia/lymphoma who are treated with reduced-intensity conditioning (RIC) with alemtuzumab (Lemtrada) allogeneic hematopoietic stem cell transplant (allo-HSCT). This study concluded that the graft-versus-lymphoma effect...
Read MoreWhat role does the graft-versus-leukemia effect have on survival in acute lymphoblastic leukemia?
In a nutshell This study aimed to investigate the impact of graft-versus-leukemia effect on survival in patients with acute lymphoblastic leukemia. This study concluded that graft-versus-leukemia effect was beneficial in certain subsets of these patients. Some background Allogeneic hematopoietic stem cell transplant (allo-HSCT) is a potentially...
Read MoreSecond cancers in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors
In a nutshell This study aimed to investigate the occurrence of second cancers in patients with chronic myeloid leukemia (CML). This study concluded that the occurrence of overall second cancers in these patients is slightly higher than that of the general population. Some background Tyrosine kinase inhibitors (TKIs) are commonly used for the...
Read MoreAllogenic hematopoietic stem cell transplant for patients with unresponsive acute myeloid leukemia
In a nutshell This study aimed to investigate the effectiveness of allogeneic hemopoietic stem cell transplant (alloHSCT) in patients with unresponsive acute myeloid leukemia. This study concluded that alloHSCT is the best treatment option for these patients. Some background Patients with unresponsive acute myeloid leukemia (AML) are those...
Read MoreA long term follow-up study of young people with acute lymphoblastic leukemia.
In a nutshell This study examined the long-term effectiveness of different treatment strategies for acute lymphoblastic leukemia (ALL) in young people. This study concluded that augmented treatment for rapid early responders was most beneficial, with improved survival at 10 years. Some background ALL is a cancer of the bone marrow. It leads to...
Read MoreCould hyperbaric oxygen therapy improve umbilical cord blood transplantation outcomes?
In a nutshell This study examined if hyperbaric oxygen therapy is safe and can improve outcomes in umbilical cord blood transplantation. This study concluded that the use of hyperbaric oxygen therapy before umbilical cord blood transplantation is safe and can improve outcomes in certain patients. Some background Stem cells allow the production...
Read MoreInfections after treatment in children with acute leukemia
In a nutshell This study aimed to investigate the occurrence of infections in children with acute lymphoblastic leukemia or acute myeloid leukemia patients that have completed treatment. This study concluded that infections are a common complication after treatment of these patients. Some background Acute lymphoblastic leukemia (ALL) and acute myeloid...
Read MoreLong-term effectiveness of tyrosine kinase inhibitors for newly diagnosed chronic-phase chronic myeloid leukemia
In a nutshell This study aimed to investigate the long-term safety and effectiveness of tyrosine kinase inhibitors for chronic-phase chronic myeloid leukemia. This study concluded that the outcomes for these patients are satisfactory and reliable. Some background Patients with chronic phase chronic myeloid leukemia (CP-CML) generally have mild...
Read MoreIs entospletinib an effective treatment for relapsed or unresponsive chronic lymphocytic leukemia?
In a nutshell This study examined if entospletinib can be used as a treatment for relapsed or unresponsive chronic lymphocytic leukemia (CLL). This study concluded entospletinib has disease reducing activity in patients with CLL, where previous treatment has failed. Some background Chronic lymphocytic leukemia (CLL) is a cancer of the bone marrow. It...
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