In a nutshell This study investigated the safety and effectiveness of upadacitinib (Rinvoq) in patients with rheumatoid arthritis (RA) who progressed after methotrexate (Otrexup). Researchers suggested that upadacitinib improved clinical and functional outcomes in these patients. Some background RA is an autoimmune disorder which occurs when the...
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Peficitinib – a drug to treat unresponsive rheumatoid arthritis?
In a nutshell This study investigated the safety and effectiveness of peficitinib (Smyraf) in patients with unresponsive rheumatoid arthritis (RA). They found that this treatment reduced RA symptoms and was well tolerated in these patients. Some background Rheumatoid arthritis (RA) is caused by painful swelling and inflammation in the...
Read MoreIs the biosimilar BCD-055 as effective as infliximab?
In a nutshell This study investigated the safety and effectiveness of BCD-055 (BCD), a biosimilar of infliximab (IFX; Remicade). They found that the safety and effectiveness of BCD were similar to IFX. Some background Rheumatoid arthritis (RA) is a chronic condition. It is caused by painful inflammation in the joints. RA...
Read MoreHow effective is filgotinib in the treatment of unresponsive rheumatoid arthritis?
In a nutshell This study investigated the effectiveness of filgotinib (FGB) in patients with unresponsive rheumatoid arthritis (RA). They found that FGB improves RA management at 12 weeks. Some background Rheumatoid arthritis (RA) is a chronic condition. Inflammation leads to painful swelling in the joints. RA is treated with...
Read MoreLeflunomide – a review of its use in the treatment of juvenile idiopathic arthritis
In a nutshell This study investigated the use of leflunomide (Arava) in juvenile idiopathic arthritis (JIA). They found that this medication may be useful in managing JIA in patients resistant or intolerant to methotrexate. Some background Juvenile idiopathic arthritis (JIA) is caused by inflammation in the joints. JIA is...
Read MoreRemission with etanercept – what degree of remission predicts long-term success?
In a nutshell This study investigated if initial remission can predict long-term remission (LTR) after etanercept (Enbrel) treatment. They found that LTR is more likely if strict disease control is achieved before etanercept withdrawal Some background Rheumatoid arthritis (RA) is a long-term condition. Disease-modifying anti-rheumatic...
Read MoreLong-term treatment with baricitinib – an analysis of the long-term safety and effectiveness
In a nutshell This study investigated the safety and effectiveness of long-term treatment with baricitinib (Olumiant) in rheumatoid arthritis (RA). They found that this drug was effective and well tolerated alone or in combination with methotrexate (MTX). Some background Rheumatoid arthritis (RA) is a long-term...
Read MoreSearching for patients with rheumatoid arthritis to test a treatment combination
In a nutshell This phase 3 trial will investigate the effectiveness of GSK3196165 combined with methotrexate (MTX). The main outcome will be the number of patients achieving a 20% improvement in symptoms (ACR20). The details Rheumatoid arthritis (RA) is a condition caused by inflammation. Drugs that reduce inflammation are used to treat RA....
Read MoreIs there a link between frailty and fracture risk in rheumatoid arthritis?
In a nutshell This study investigated if there is a link between frailty and fracture (breaking of a bone) risk in rheumatoid arthritis (RA). They found that patients with higher frailty were more likely to have bone fractures. Some background Rheumatoid arthritis (RA) is a chronic immune condition. It is caused by painful...
Read MoreAbatacept – what is the safety profile in rheumatoid arthritis treatment?
In a nutshell This study investigated the safety of abatacept (Orencia) compared to other disease-modifying anti-rheumatic drugs (DMARDs). They found that this treatment was well tolerated and had a similar safety profile to other DMARDs. Some background Rheumatoid arthritis (RA) is a chronic condition. It is caused by painful swelling...
Read MoreMethotrexate vs. biologics – which is more effective as a first-line treatment?
In a nutshell This study investigated the effectiveness of methotrexate (MTX) versus tocilizumab (TCZ) in early rheumatoid arthritis (RA). They found that TCZ patients had a greater reduction in disease activity (DA). Some background Rheumatoid arthritis (RA) is a chronic condition. It is caused by excessive inflammation...
Read MoreOrofacial symptoms and dentofacial deformities in patients with juvenile idiopathic arthritis
In a nutshell This study investigated the rates of orofacial symptoms (OFS) and dentofacial deformities (DFD) in patients with juvenile idiopathic arthritis (JIA). They found that OFS and DFD rates were high in JIA. Some background Juvenile idiopathic arthritis (JIA) is an inflammatory condition that affects children. JIA leads to painful...
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