In a nutshell This study investigated if switching from etanercept (Enbrel) to a biosimilar of etanercept (SDZ-ETN) is safe and effective in patients with rheumatoid arthritis (RA). They found that switching to SDZ-ETN from reference etanercept was safe and effective. Some background Rheumatoid arthritis (RA) is a long-term...
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Peficitinib in rheumatoid arthritis: is it safe and effective?
In a nutshell This study investigated the safety and effectiveness of peficitinib (Smyraf) in rheumatoid arthritis (RA). They found that peficitinib improved RA symptoms and slowed joint damage. Some background Rheumatoid arthritis (RA) is caused by inflammation in the joints. This is very painful and leads to joint damage....
Read MoreAn update on the long-term safety and effectiveness of etanercept in juvenile idiopathic arthritis
In a nutshell This study investigated the long-term safety and effectiveness of etanercept (Enbrel) in juvenile idiopathic arthritis (JIA). They found that etanercept is well tolerated and effective on the long-term in patients with JIA. Some background Juvenile idiopathic arthritis (JIA) is an inflammatory condition...
Read MoreGolimumab in rheumatoid arthritis – investigating the safety and efficacy of intravenous administration
In a nutshell This study investigated golimumab (Simponi; GLM) in patients with rheumatoid arthritis (RA) in patients over 65 compared to those under 65. They found that intravenous (IV) GLM was effective and well tolerated in these patients. Some background Rheumatoid arthritis (RA) is caused by chronic inflammation in the joints. RA...
Read MoreIs there a greater risk of serious infection with tumor necrosis factor inhibitors for rheumatoid arthritis?
In a nutshell This study investigated the risk of serious infections with tumor necrosis factor inhibitors (TNFi) in patients with rheumatoid arthritis (RA). They found no difference in serious infection risk with TNFi treatment compared to triple therapy. Some background Rheumatoid arthritis (RA) is a chronic disease. It is caused by excessive...
Read MoreIs upadacitinib more effective than adalimumab in patients with rheumatoid arthritis treated with methotrexate?
In a nutshell This study investigated upadacitinib (Rinvoq) versus adalimumab (Humira) as add-on to methotrexate in patients with rheumatoid arthritis (RA). They found that upadacitinib was more effective in improving RA symptoms compared to adalimumab. Some background Rheumatoid arthritis (RA) is an auto-immune...
Read MoreUpadacitinib improves clinical outcomes of patients with rheumatoid arthritis
In a nutshell This study investigated the safety and effectiveness of upadacitinib (Rinvoq) in patients with rheumatoid arthritis (RA) who progressed after methotrexate (Otrexup). Researchers suggested that upadacitinib improved clinical and functional outcomes in these patients. Some background RA is an autoimmune disorder which occurs when the...
Read MorePeficitinib – a drug to treat unresponsive rheumatoid arthritis?
In a nutshell This study investigated the safety and effectiveness of peficitinib (Smyraf) in patients with unresponsive rheumatoid arthritis (RA). They found that this treatment reduced RA symptoms and was well tolerated in these patients. Some background Rheumatoid arthritis (RA) is caused by painful swelling and inflammation in the...
Read MoreIs the biosimilar BCD-055 as effective as infliximab?
In a nutshell This study investigated the safety and effectiveness of BCD-055 (BCD), a biosimilar of infliximab (IFX; Remicade). They found that the safety and effectiveness of BCD were similar to IFX. Some background Rheumatoid arthritis (RA) is a chronic condition. It is caused by painful inflammation in the joints. RA...
Read MoreHow effective is filgotinib in the treatment of unresponsive rheumatoid arthritis?
In a nutshell This study investigated the effectiveness of filgotinib (FGB) in patients with unresponsive rheumatoid arthritis (RA). They found that FGB improves RA management at 12 weeks. Some background Rheumatoid arthritis (RA) is a chronic condition. Inflammation leads to painful swelling in the joints. RA is treated with...
Read MoreLeflunomide – a review of its use in the treatment of juvenile idiopathic arthritis
In a nutshell This study investigated the use of leflunomide (Arava) in juvenile idiopathic arthritis (JIA). They found that this medication may be useful in managing JIA in patients resistant or intolerant to methotrexate. Some background Juvenile idiopathic arthritis (JIA) is caused by inflammation in the joints. JIA is...
Read MoreRemission with etanercept – what degree of remission predicts long-term success?
In a nutshell This study investigated if initial remission can predict long-term remission (LTR) after etanercept (Enbrel) treatment. They found that LTR is more likely if strict disease control is achieved before etanercept withdrawal Some background Rheumatoid arthritis (RA) is a long-term condition. Disease-modifying anti-rheumatic...
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