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Posted by on Jan 3, 2019 in Non-Hodgkin lymphoma | 0 comments

In a nutshell

This study looked at the safety and effectiveness of CT-P10 (Truxima) compared to rituximab (Rituxan) in the treatment of follicular lymphoma. Researchers found that CT-P10 had similar safety and effectiveness as rituximab in these patients.

Some background

Lymphoma is a cancer of the immune system. It is often treated with drugs which target the immune system. Rituximab is an example of these medications, called biological therapy. It is commonly used for the treatment of follicular lymphoma (FL). It is an original drug that involves high treatment prices.

To reduce treatment costs, an alternative is a biosimilar drug. This is a biological medicine with a very similar structure to an original, approved drug. These usually come with a 20-35% lower price.  CT-P10 is a rituximab biosimilar drug. The safety and effectiveness of CT-P10 compared to rituximab remain under investigation.

Methods & findings

258 patients with FL were included in this study. 130 patients received CT-P10 and 128 received rituximab. Overall response rates were assessed.

83% of patients given CT-P10 and 81% of those treated with rituximab had a treatment response by 7 months. Side effects were reported in 71% of patients in the CT-P10 group and 67% in the rituximab group. 5% of those who received CT-P10 and 2% of patients on rituximab had serious side effects. The most common side effect was a low white cell count.

The bottom line

The study concluded that CT-P10 and rituximab are similar in safety and effectiveness in the treatment of FL.

The fine print

This study was funded by Celltrion, the manufacturer of CT-P10. CT-P10 (Truxima) was recently approved by the FDA for the treatment of previously untreated FL.

Published By :

The Lancet. Haematology

Date :

Nov 01, 2018

Original Title :

Efficacy, pharmacokinetics, and safety of the biosimilar CT-P10 in comparison with rituximab in patients with previously untreated low-tumour-burden follicular lymphoma: a randomised, double-blind, parallel-group, phase 3 trial.

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