Welcome to Medivizor!

You're browsing our sample library. Feel free to continue browsing. You can also sign up for free to receive medical information specific to your situation.

Posted by on Oct 7, 2018 in Leukemia | 0 comments

In a nutshell

The study looked at the safety and effectiveness of combining different chemotherapy drugs followed by stem-cell transplant for the treatment of unresponsive acute myeloid leukemia (AML). Researchers found that this method was safe and effective in the patients studied.

Some background

Acute myeloid leukemia is a cancer of the bone marrow which affects the immune system. It is often treated by deleting the abnormal cells with chemotherapy drugs (myeloablation) and replacing them with donor stem cells.  It is important to research the safety and effectiveness of this method.

Methods & findings

24 patients with AML unresponsive to treatment were included in the study. Chemotherapy with Cladribine (Leustatin) and cytarabine (Cytosar-U) was given for 5 days and mitoxantrone (Novantrone) was given for 3 days. This is known as the CLAM regimen. Patients then received busulfan (Myleran) for 4 days and cyclophosphamide (Cytoxan) for 2 days to delete abnormal cells. Donor stem cell therapy was then given to all patients.

At the time of transplantation, 62.5% of patients had some abnormal cells in their blood. 29.8% of patients had symptoms of AML that returned within 2 years. 74.5% of patients survived overall after 1 year and 56.5% at 2 years. 62.5% of patients survived without signs of leukemia at 1 year and 50.5% at 2 years.

The bottom line

The study concluded that combination chemotherapy with the CLAM regimen before stem cell transplant was safe and effective in the treatment of AML.

The fine print

This was a phase 2 clinical trial, with a small sample size and did not follow patients up for a long period. Larger and longer studies are required for more accurate results.

What’s next?

Talk to your doctor about using chemotherapy before stem cell transplant for AML.

Published By :

Annals of Hematology

Date :

Aug 04, 2018

Original Title :

Sequential treatment combining cladribine-based re-induction, myeloablative allogeneic HSCT, and prophylactic donor lymphocyte infusion: a promising treatment for refractory acute myeloid leukemia.

click here to get personalized updates