In a nutshell The study aimed to investigate optimized conformal (OC) total body irradiation (TBI) in pediatric patients with blood cancers who received further chemotherapy and allogeneic hematopoietic stem cell transplant (alloHSCT) with TCRαβ/CD19 depletion. This study concluded that OC-TBI is a...
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In a nutshell This study aimed to compare enasidenib (Idhifa) to current standard of care therapies for patients with relapsed/refractory (r/r) acute myeloid leukemia (AML) and an isocitrate dehydrogenase 2 (IDH2) mutation who are ineligible for hematopoietic stem cell transplantation (HSCT). This study concluded that enasidenib significantly...
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In a nutshell This study described the real-world effectiveness and safety of arsenic trioxide (ATO; Trisenox) combined with all-trans retinoic acid (ATRA; Vesanoid), without chemotherapy, in patients with newly diagnosed acute promyelocytic leukemia (APL). The authors concluded that a combination of ATO and ATRA showed good results for the...
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In a nutshell This study aimed to investigate the safety and effectiveness of venetoclax (Venclexta) combined with intensive chemotherapy in patients aged 65 or younger with acute myeloid leukemia (AML). This study concluded that venetoclax added to intensive chemotherapy was safe and effective in these...
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In a nutshell This study aimed to review existing evidence regarding the outcome of tyrosine kinase inhibitor (TKI) maintenance therapy after allogeneic stem-cell transplantation (allo-SCT) in patients with FLT3-ITD mutated (genetic abnormality) acute myeloid leukemia (AML). This study concluded that TKI maintenance therapy after...
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In a nutshell This study aimed to compare outcomes for allogeneic hematopoietic stem cell transplantation (alloHSCT) using haploidentical and matched sibling donors in patients with acute myeloid leukemia (AML). This study concluded that both donor types provided similar outcomes for these patients. Some background Allogeneic...
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In a nutshell This study investigated the effectiveness of azacitidine (Onureg) tablets as maintenance therapy in patients with acute myeloid leukemia (AML) in first remission after intensive chemotherapy. The data showed that azacitidine tablets improved the survival of these patients. Some background Acute myelogenous leukemia (AML) is a...
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In a nutshell This study aimed to investigate two pre-transplant conditioning regimes for patients with acute myeloid leukemia. This study concluded that total body irradiation and fludarabine (Fludara) may be a suitable reduced toxicity conditioning treatment option for these patients. Some background A conditioning...
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In a nutshell This study aimed to investigate the outcomes of a second hematopoietic stem cell transplant (HSCT) after reduced-intensity conditioning (RIC) for patients with leukemia or lymphoma. This study concluded that this treatment path is feasible and a good alternative for these patients. Some background Allogenic hemopoietic...
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In a nutshell This study aimed to compare outcomes of salvage chemotherapy for patients with relapsed or refractory acute myeloid leukemia. This study concluded that the CLAG-M regimen (cladribine, cytarabine, filgrastim, and mitoxantrone) followed by transplant is a suitable salvage treatment for these patients. Some...
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In a nutshell This study aimed to further investigate the safety and tolerability of midostaurin plus chemotherapy in patients with newly diagnosed FLT3 mutation-positive acute myeloid leukemia. This study concluded that this combination was safe and effective in these patients. Some background FLT3 is a mutation...
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In a nutshell This study aimed to investigate the association between total body irradiation and further breast cancer diagnosis in patients treated with blood or marrow transplantation for leukemia-lymphoma. This study concluded that there is an association between the total body irradiation and an increased risk of breast cancer in...
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