This trial will evaluate endometrial receptivity analysis (ERA) in patients undergoing assisted reproduction (AR). The main outcome will be the live birth rate (LBR).
The details
Assisted reproduction (AR) involves technologies (ART) to achieve a pregnancy. In vitro fertilization (IVF) involves fertilizing the egg and sperm in a laboratory. After this, embryos are transferred to the uterus (womb). This is called embryo transfer (ET). ET is can be performed with fresh or frozen embryos. If successful, embryos will implant in the lining of the uterus. This is called the endometrium (EM). ET is performed during the window of implantation (WOI). Some patients that undergo IVF/ET may have a displaced WOI. The WOI may be shorter than expected in some patients.
To maximize the success of ET, there is a test called endometrial receptivity analysis (ERA). The ERA may help identify if the uterus is can receive the embryo. It may be useful for improving ART success.
Who are they looking for?
This study will recruit 740 women. Participants should be planning to undergo ET with frozen embryos. Embryos must be evaluated for genetic abnormalities using pre-implantation genetic testing (PGT-A).
Patients cannot take part in the trial if they have conditions affecting the uterus. Any medical conditions that are unstable will also prevent a patient from taking part in the trial.
How will it work
Patients will be assigned to a treatment or control groups. All patients must have previously undergone PGT-A. Before ET, one group of patients will have an ERA. The timing of ET will be based on the ERA results. In the control group, ET will be performed during the predicted WOI.
