Welcome to Medivizor!

You're browsing our sample library. Feel free to continue browsing. You can also sign up for free to receive medical information specific to your situation.

Posted by on Sep 5, 2021 in Hypertension | 0 comments

In a nutshell

This study looked at the effect of blood pressure (BP)-lowering medications on cerebral small vessel disease (CVSD). It found that maintaining systolic blood pressure (SBP; BP when the heart beats) between 110-129 mmHg reduced the progression of white matter hyperdensities, one of the signs of CVSD on brain scans.

Some background

Cerebral small vessel disease (CSVD) is a condition affecting the small blood vessels in the brain. CVSD is often seen on brain scans. On scans, small areas of damage to the brain can be seen in the form of white matter hyperintensities (WMH). Another sign of CVSD on brain scans is brain atrophy or shrinking of the brain. CVSD can result in strokes, dementia, or mental health problems.

It is not clear if blood pressure treatment can improve signs of CVSD on brain scans.

Methods & findings

This study reviewed the results of 7 studies involving a total of 1,944 patients aged 60-78. All patients had evidence of CSVD on brain scans. The relation between BP medications and worsening of CSVD on brain scans was evaluated. 

Patients with lower BP levels on treatment (SBP of 110-129 mmHg) showed less progression of WMH than patients with higher BP levels. Blood pressure treatment did not have any effect on brain atrophy.

The bottom line

This study showed that strict blood pressure control reduces the progression of WMH on brain scans, one of the signs of CVSD.  

The fine print

This study is based on previous studies, some of which are small or imperfectly designed. Further studies are needed to explore this question.

Published By :


Date :

Jul 30, 2021

Original Title :

The relation between antihypertensive treatment and progression of cerebral small vessel disease: A systematic review and meta-analysis of randomized controlled trials.

click here to get personalized updates