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Home»Infertility» Invitation to a trial examining whether injecting human chorionic gonadotropin increases implantation rates in in vitro fertilization
Clinical Trial
Invitation to a trial examining whether injecting human chorionic gonadotropin increases implantation rates in in vitro fertilization
This trial will examine whether introducing human chorionic gonadotropin into the uterus prior to implantation increases the success rate of in vitro fertilization. The effectiveness of this treatment will be measured through the implantation, pregnancy, and ongoing pregnancy rates. This trial is being conducted in Atlanta, Georgia.
The details
In vitro fertilization (IVF) is an assisted reproductive technique in which an egg is fertilized by sperm outside of the body, and the resulting embryo is then placed in the uterus. However, during IVF the endometrium (lining of the uterus) does not receive signals from the developing embryo as it would in a natural pregnancy, therefore the uterus is not optimally prepared for implantation at the time of embryo transfer.
Some studies suggest that introducing human chorionic gonadotropin (HCG, a hormone produced by the placenta during early pregnancy) to the uterus can increase the rates of successful implantation. This trial will examine whether injecting a small amount of HCG into the uterus prior to embryo transfer will increase the rate of pregnancy in women undergoing in vitro fertilization.
Who are they looking for?
This study will enroll 75 women undergoing IVF who have a good expectation of having two embryos on day 3 or day 5 of their cycle. Women using donor eggs may also be included.
Women will be excluded if they have any abnormalities of the uterus.
How will it work
Prior to the embryo transfer during a given IVF cycle, a small amount of fluid containing HCG will be injected into the uterus using a catheter (small, thin, flexible tube). The success of this treatment will be measured by the rate of achieved pregnancies, by the rate of implantation, and by the rate of ongoing pregnancies.
