In a nutshell
This study looked at the use of medication delivered to the spinal area (intrathecal) in patients with acute lymphoblastic leukemia (ALL). Researchers showed that this may be used instead of radiation to the head in these patients, with similar outcomes.
Some background
Acute lymphoblastic leukemia is a cancer of the immune system that may affect children. It is often treated with strong medication. Radiation to the head may be given to prevent spread. This is linked to many side effects. Intrathecal therapy involves injecting medication into the spinal area. This may be effective and avoid the use of head radiation.
Methods & findings
Two groups were included in this study. Group 1 had 903 patients and received radiation to the head. Group 2 had 444 patients and received intrathecal therapy.
There was a similar survival rate for patients alive without signs of cancer in group 1 (75.7%) compared to group 2 (72.1%) after 5 years. Risk of disease in the brain and spinal cord was 6.3% in group 1 compared to 3.6% in group 2.
The bottom line
The study concluded that delaying intrathecal therapy until clearance of blood tests and not using radiation to the brain was safe in patients with ALL.
The fine print
The groups in this study had different sample sizes. This may affect results.
Published By :
Cancer
Date :
Oct 11, 2018
