In a nutshell
This study looked at the safety and effectiveness of collagenase Clostridium histolyticum (CCh, Xiaflex) in treating Peyronie’s Disease (PD). The study found that injection of CCh improved symptoms of PD.
Some background
Peyronie’s disease is a condition where scar tissue forms in the penis. This may cause an abnormal bend or curve and reduce sexual function. CCh is a chemical from a bacteria that can break down the scar tissue in the penis. It is necessary to assess the safety and effectiveness of this treatment for PD.
Methods & findings
49 patients with PD who received CCh were analyzed. Patients were followed for an average of 183 days.
After 6 months of treatment, abnormal curvature was reduced by 32.4%. 10 out of 22 patients regained the ability to have vaginal intercourse. There was a 29.1% improvement in the ability to perform intercourse overall. There were no significant changes in penile pain. Five (10.2%) patients had bleeding and 1 patient had a penile fracture.
The bottom line
This study concluded that injection of CCh is an effective method of treating PD.
The fine print
More research is required on safety and comparing treatments.
What’s next?
Talk to your doctor about using CCh to treat Peyronie’s disease.
Published By :
Urology
Date :
May 17, 2016
