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Posted by on Dec 11, 2017 in Erectile dysfunction | 0 comments

In a nutshell

This study looked at the safety and effectiveness of collagenase Clostridium histolyticum (CCh, Xiaflex) in treating Peyronie’s Disease (PD). The study found that injection of CCh improved symptoms of PD. 

Some background

Peyronie’s disease is a condition where scar tissue forms in the penis. This may cause an abnormal bend or curve and reduce sexual function. CCh is a chemical from a bacteria that can break down the scar tissue in the penis. It is necessary to assess the safety and effectiveness of this treatment for PD.

Methods & findings

49 patients with PD who received CCh were analyzed. Patients were followed for an average of 183 days.

After 6 months of treatment, abnormal curvature was reduced by 32.4%. 10 out of 22 patients regained the ability to have vaginal intercourse. There was a 29.1% improvement in the ability to perform intercourse overall. There were no significant changes in penile pain. Five (10.2%) patients had bleeding and 1 patient had a penile fracture.

The bottom line

This study concluded that injection of CCh is an effective method of treating PD.

The fine print

More research is required on safety and comparing treatments.

What’s next?

Talk to your doctor about using CCh to treat Peyronie’s disease.

Published By :


Date :

May 17, 2016

Original Title :

Peyronie’s Disease and Injectable Collagenase Clostridium Histolyticum: Safety, Efficacy and Improvements in Subjective Symptoms.

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