The effect of Iranian propolis in patients with type 2 diabetes

This article investigated the safety and effectiveness of Iranian propolis (IP) on glucose metabolism (GM), lipid (fat) profile (LP), insulin resistance (IR), kidney and liver function and inflammatory biomarkers (IB) in patients with type 2 diabetes (T2D). The authors concluded that IP is effective for these patients.

T2D is a disorder where the body can no longer use insulin correctly. This results in high blood glucose. Current treatment options include medications to lower blood glucose and lifestyle changes (healthy diet and exercise). 

An alternative treatment option is IP. Propolis is a natural, resin-like compound that honeybees collect from different plants. It has many benefits including lowering blood glucose levels. However, the effects of IP on glucose and lipid metabolism, liver and kidney function and inflammatory markers is still under investigation. 

The study involved 94 patients with T2D. They were divided into two groups. Group 1 (50) received 1000 mg/day of IP. Group 2 (44) received 1000 mg/day of a placebo (inactive drug). The study lasted for 90 days.

At follow-up, group 1 had a significant decrease in HbA1c (a blood glucose control measurement over the past 3 months), from 8,65% to 7.67%. This decrease was not seen in group 2. Group 2 also had significantly lower blood glucose 2 hours after eating, lower levels of insulin resistance (how well the cells use the limited insulin) and lower inflammatory markers at follow-up.

Group 1 also had an increase in high-density lipoprotein (HDL; good cholesterol) and a reduction in liver enzymes (healthier liver cells and less inflammation). 

The authors concluded that IP is an effective treatment option for patients with T2D. 

This study had a very small number of participants and a short follow-up period. Larger studies are needed to confirm the benefits of IP in these patients. 

If you have concerns regarding blood glucose control, discuss this with your doctor.