Local treatment in metastatic colorectal cancer is a safe option for the elderly and for patients with other medical conditions

This study investigated whether local ablative methods (LAT; non-invasive procedures) of treatment can be used in patients with colorectal cancer that are older or have other medical conditions. Researchers suggested that these procedures may be performed safely in these patients.

Age is a major risk factor for colorectal cancer. Also, elderly patients often suffer from other conditions that are considered when making treatment decisions. 

LAT methods can be an alternative to more invasive methods such as surgery, which is often related to complications. LAT methods include radiofrequency ablation (RFA), brachytherapy (BRT) or Y90 radioembolization (Y90-RE). RFA consists of using a medium frequency current to generate heat that will kill tumor cells. BRT involves implanting a seed that releases high dose radiation directly into the tumors. Y90-RE uses radioactive particles that are delivered to the tumor through the blood vessels that feed the tumors.

Prior studies showed that LAT methods can achieve long-term disease control in patients with inoperable colorectal cancer by completely removing the tumor. However, studies including elderly patients are limited.

This study included information about 266 patients with advanced colorectal cancer. All patients were treated with LAT procedures. 196 patients had metastasis (spread to other parts of the body) within 12 months after diagnosis. 

Overall average survival of the patients was 14 months. Being 70 years old or older did not influence the treatment outcomes. Also, patients who had other serious medical conditions did not have a different outcome compared with those who did not. However, kidney disease was associated with poorer outcomes.

45% of patients further received chemotherapy. These patients had a 29% higher chance of survival compared to those who did not receive further therapy.

This study showed that non-invasive methods for advanced colorectal cancer such as LAT may be performed safely in the elderly and in people with other medical conditions. 

This study looked back at data from the medical records of patients. Relevant data which could affect the results could have been missing.

Talk to your doctor about the possibility of LAT treatment.