In a nutshell This study aimed to evaluate the use of irreversible electroporation (IRE) in the treatment of prostate cancer. This study found that IRE had low side-effect rates and promising outcomes. Some background Irreversible electroporation (IRE) uses high-energy pulses of electricity to destroy cancer cells. The brand name for...
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In a nutshell This study investigated the rate of bladder cancer (BC) and rectal cancer (RC) after localized prostate cancer (PC) treatment. They found that brachytherapy (BT) increased the risk of BC and RC in these patients. Some background Prostate cancer (PC) is a common cancer in men. There are many treatment options for PC. Some involve...
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In a nutshell This article investigated the toxicity of intensity-modulated radiation therapy (IMRT) to the prostate and pelvic lymph nodes (PPLN-IMRT) compared with prostate-only (PO-IMRT) in high-risk prostate cancer (PC). The authors concluded that both treatments had similar toxicity rates in these patients. Some background...
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In a nutshell This article investigated the safety and effectiveness of salvage high-intensity focused ultrasound (S-HIFU) in patients with locally recurrent prostate cancer (LRPC; cancer which has come back and is confined to the prostate gland) after treatment with low dose rate brachytherapy (BT). The authors concluded that S-HIFU is...
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Nanodrugs have been around for some time. In fact, over 250 drugs using nanotechnology that have been approved by the FDA and are in clinical use. The name nanodrug or nanopharmaceuticals refers to the size of the particle that is created to house the medication. A nano is very tiny: nanoparticles are between 1 and 100 nanometers in at least one of its...
Read MoreIn a nutshell This study aimed to investigate the outcomes of intermediate risk-risk prostate cancer after different treatments. This study concluded that prostate surgery might have a higher survival than radiotherapy. Some background There a several options to treat intermediate-risk prostate cancer (IR-PC). Radical prostatectomy (RP; surgery to...
Read MoreIn a nutshell This phase 2 trial is examining the effectiveness and safety of trametinib (Mekinist) in patients with metastatic castration-resistant prostate cancer (mCRPC; prostate cancer which has spread from its original place to another area in the body and keeps growing even when the amount of testosterone in the body...
Read MoreIn a nutshell This phase 2 trial is examining the effectiveness and safety of navarixin (MK-7123) in combination with pembrolizumab (Keytruda) in patients with castration-resistant prostate cancer (CRPC; cancer that progresses after hormonal therapy). The main outcome to be measured will be the objective response rate (ORR; tumor shrinkage or...
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In a nutshell This article investigated the risk of new primary (cancer that does not originate in another organ) cancers after treatment with carbon ion radiotherapy (CIRT), photon radiotherapy (PRT) or surgery for localized prostate cancer (PC). The authors concluded that CIRT is associated with a lower risk of new primary cancers vs...
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In a nutshell This article investigated the safety and efficacy of end-to-side nerve grafting surgery (NGS) in patients with erectile dysfunction (ED) after prostate surgery. The authors concluded that NGS was a safe and effective treatment option for these patients. Some background Radical prostatectomy (RP) is surgery to remove the prostate....
Read MoreIn a nutshell This article investigated urinary function in elderly vs younger men following robot-assisted radical prostatectomy (RARP) for aggressive prostate cancer (PC). The authors concluded that regardless of age, there was an improvement in urinary function after the surgery. Some background Aggressive prostate cancer is commonly...
Read MoreIn a nutshell This article investigated the link between blood glucose control and long-term prostate cancer (PC) outcomes in men with diabetes mellitus (DM) who are having a radical prostatectomy (RP; complete removal of the prostate). The authors concluded that a worse blood glucose control was associated with metastases and...
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