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Posted by on Jul 9, 2019 in Prostate cancer | 0 comments

In a nutshell

This study aimed to evaluate the use of irreversible electroporation (IRE) in the treatment of prostate cancer. This study found that IRE had low side-effect rates and promising outcomes. 

Some background

Irreversible electroporation (IRE) uses high-energy pulses of electricity to destroy cancer cells. The brand name for IRE is called NanoKnife. It can be used in prostate cancer. It is unknown how safe and effective it is for the treatment of localized prostate cancer.

Methods & findings

This study included 30 men. Patients filled out questionnaires evaluating their quality of life at the time of surgery and 12 months later. People were followed up for an average of 20 months.

PSA (prostate-specific antigen) is used as a tumor marker in blood tests. This maker decreased 12 months after having IRE from 8.65 to 2.35. 17.9% of men had another treatment in the first 12 months due to persistent cancer cells.

Side-effects such as incontinence rates worsened slightly between baseline and 12 months after. However, 24 months after surgery 100% of people were pad-free. One person reported having a narrowing of the urethra (the tube which conducts urine and semen out). Out of 83.3% of patients who had good erectile function before the procedure, 79.3% preserved this function after 12 months.

The bottom line

This study found that IRE had low side-effect rates and promising outcomes for patients with localized prostate cancer. 

The fine print

This study had a very small number of participants and a short follow-up. Further, larger studies are needed for stronger evidence.

Published By :


Date :

Jun 04, 2019

Original Title :

Image-guided Irreversible Electroporation of Localized Prostate Cancer: Functional and Oncologic Outcomes.

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