In a nutshell This phase 2 trial will investigate the safety and effectiveness of REGN2810 with androgen deprivation therapy (ADT) and docetaxel (Taxotere) in advanced hormone-sensitive prostate cancer (hsPC). The main outcome will be the percentage of patients with undetectable PSA (prostate-specific antigen; a marker of prostate cancer)...
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Oncological safety of testosterone replacement therapy in prostate cancer survivors after definitive local therapy
In a nutshell This study aimed to evaluate the use of testosterone replacement therapy (TRT) in men who had definitive treatment for prostate cancer. The authors concluded that TRT was not associated with a higher risk of recurrence in these patients. Some background Prostate cancer (PCa) is commonly fueled by the sex hormone testosterone....
Read MoreComparing the effectiveness of various treatments for high-risk prostate cancer
In a nutshell This study compared the effectiveness of current treatment options for high-risk prostate cancer (PCa). It found that RP is the preferred treatment option for these patients. Some background Prostate surgery (RP) is a common treatment option for high-risk PCa. Radiation therapy (RT), androgen deprivation therapy...
Read MoreLooking for patients with prostate cancer to test a type of radiation treatment
In a nutshell This phase 3 trial will compare the safety and effectiveness of hypofractionated radiotherapy (HF-RT) to standard radiotherapy (RT). The main outcomes will be the number of grade 2 side effects and disease control. This trial is recruiting in Houston, Texas, United States. The details Radiation therapy (RT) is a...
Read MoreEvaluating enzalutamide to treat metastatic prostate cancer
In a nutshell This study aimed to examine the effectiveness and safety of enzalutamide (Xtandi) in metastatic prostate cancer. This study found that enzalutamide was associated with longer progression-free and overall survival compared to standard of care. Some background Enzalutamide is an anti-androgen medication....
Read MoreMaking the Right Choice for Prostate Cancer Treatment
The prostate is a tiny gland in a crowded part of the body. It is situated right below the bladder, right next to the rectum, near the blood and nerve supply for the penis. Unfortunately, one in nine men will get cancer in this tiny gland. According to the UsToo International prostate cancer website, nearly 3 million men in the US are living with prostate...
Read MoreLooking for patients with advanced prostate cancer to test a new drug
In a nutshell This phase 1 trial will investigate the safety of an experimental drug, XmAb22841 (XmAb), to treat advanced cancer. The main outcome will be the safety and tolerability of XmAb. This study is recruiting in Georgia and Texas, USA. The details Advanced cancer can be difficult to treat. New drugs are being developed to address this. Immune...
Read MoreUltra-hypofractionated versus conventionally fractionated radiotherapy for prostate cancer
In a nutshell This study aimed to evaluate ultra-hypofractionated radiation therapy (UHFRT). This study found that UHFRT is safe and effective in the treatment of prostate cancer. Some background One option for the treatment of prostate cancer is radiation therapy. Conventional radiation treatment (CRT) involves using small doses of radiation 5...
Read MoreOutcomes and side-effects after prostate surgery and intensity modulated radiation therapy
In a nutshell This study aimed to investigate long-term outcomes of radiation therapy after prostate surgery for prostate cancer. This study found that this is a safe treatment option for these patients. Some background Prostate surgery is a common treatment for prostate cancer (PCa). Intensity-modulated radiation therapy (IMRT) is another option....
Read MoreDepression in prostate cancer survivors
In a nutshell This study aimed to investigate depression in prostate cancer patients. This study found that depression is a major challenge for prostate cancer survivors. Some background Men who are diagnosed with cancer can have a higher risk of developing depression. However, it is unclear how many patients with prostate cancer experience...
Read MoreEvaluating types of robotic surgery for prostate cancer
In a nutshell This study aimed to investigate a surgical procedure used to treat prostate cancer, retzius sparing laparoscopic robotic-assisted radical prostatectomy (RS-RALP). This study found that RS-RALP had similar side-effects and outcomes to other robotic surgeries. Some background Prostate surgery is a treatment option for prostate cancer...
Read MoreMale urethral “Mini-Sling” in treating stress urinary incontinence and climacturia after prostate cancer treatment
In a nutshell This study aimed to investigate the use of the 'mini-sling' surgery during placement of penile prosthesis for the treatment of urinary incontinence and climacturia (urine leaking during sexual intercourse) in men with erectile dysfunction after prostate cancer treatment. This study found that this procedure is promising for these...
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