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Posted by on Sep 19, 2016 in Prostate cancer | 0 comments

In a nutshell

The main objective of this study was to review all data available on focal radiotherapy (FRT) for men with early prostate cancer. The authors concluded that FRT was an option in early prostate cancer but may not be as effective in intermediate-risk tumors.

Some background

Radiation therapy is an important part of prostate cancer treatment. Radiation therapy involves directing radiation at the prostate in order to kill the cancer cells while causing minimal damage to healthy cells. 

FRT is a form of radiation therapy. FRT is a more targeted form of this treatment where a specific, small cancer site is targeted rather than an entire area. For example, external beam radiation (EBR) involves directing a single or multiple beams of radiation from an external source at the tumor site. Brachytherapy involves implanting a radiation source at the tumor site. 

It is still not clear whether FRT is an effective primary treatment option for low- or intermediate-risk prostate cancer.

Methods & findings

The main aim of this review was to analyze available data on FRT and its benefit in treating early prostate cancer.
22 previous trials were reviewed. 11 trials dealt with all types of focal therapy including FRT and 2 articles dealt with FRT only using brachytherapy and EBR. Seven other studies, including 715 patient cases, examined FRT. 99% of these patients received brachytherapy as an FRT and 1% received EBR.
 
FRT showed promising tumor control in low-risk cancer patients. In one study examined, 318 patients with low or intermediate risk prostate cancer who received brachytherapy FRT were analyzed over a 5-year follow-up period.
95.1% of low-risk patients were recurrence free (based on blood tests) after 5 years, and 80.4% at 8 years. In comparison, 73% of intermediate-risk patients were recurrence free after 5 years, and 66.4% at 8 years.
 
 
 
 

The bottom line

The authors concluded that primary FRT was a possible option in early prostate cancer but may be suboptimal in intermediate-risk tumors. 

Published By :

Critical reviews in oncology/hematology

Date :

Sep 01, 2016

Original Title :

Primary focal prostate radiotherapy: Do all patients really need whole-prostate irradiation?

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