In a nutshell
This study aimed to review the advanced treatment options available for non-motor symptoms of Parkinson's disease (PD).
Some background
Parkinson’s disease (PD) affects the nerve cells in the brain that produce dopamine. PD symptoms include muscle rigidity, tremors, and changes in speech and walk. Symptoms can be split into motor (tremor) and non-motor. Non-motor symptoms can include depression, sleep disorders, pain, and vision problems. It is important to evaluate available treatment for these symptoms in patients with PD.
Methods & findings
This study reviewed treatment recommendations from 37 other studies.
Dopamine replacement medications may improve depression, insomnia, and fatigue. However, they can worsen psychosis, impulse control or constipation. Careful monitoring of patients on these medications is important.
Dopamine receptor drugs may be of use in the treatment of gastric issues such as nausea. Opiates (such as morphine or morphine-like drugs) can be used in the treatment of pain. Sleep disorders can be treated by identifying the cause. Changing PD therapies and sleep hygiene can improve night symptoms. There were no clinically useful interventions identified to treat memory and thinking problems.
The bottom line
This study reviewed current treatment options for non-motor PD symptoms. They recommended the development and testing of new treatments for nonmotor symptoms in PD.
The fine print
There are few treatment options for nonmotor symptoms in PD. More research is needed.
What’s next?
If you are experiencing any of these symptoms discuss your treatment options with your doctor.
Published By :
Movement disorders: official journal of the Movement Disorder Society
Date :
Jan 17, 2019
