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Posted by on Feb 27, 2019 in Parkinson's Disease | 0 comments

In a nutshell

This study aimed to review the advanced treatment options available for non-motor symptoms of Parkinson's disease (PD). 

Some background

Parkinson’s disease (PD) affects the nerve cells in the brain that produce dopamine. PD symptoms include muscle rigidity, tremors, and changes in speech and walk. Symptoms can be split into motor (tremor) and non-motor. Non-motor symptoms can include depression, sleep disorders, pain, and vision problems. It is important to evaluate available treatment for these symptoms in patients with PD.

Methods & findings

This study reviewed treatment recommendations from 37 other studies. 

Dopamine replacement medications may improve depression, insomnia, and fatigue. However, they can worsen psychosis, impulse control or constipation. Careful monitoring of patients on these medications is important.

Dopamine receptor drugs may be of use in the treatment of gastric issues such as nausea. Opiates (such as morphine or morphine-like drugs) can be used in the treatment of pain. Sleep disorders can be treated by identifying the cause. Changing PD therapies and sleep hygiene can improve night symptoms. There were no clinically useful interventions identified to treat memory and thinking problems. 

The bottom line

This study reviewed current treatment options for non-motor PD symptoms. They recommended the development and testing of new treatments for nonmotor symptoms in PD.

The fine print

There are few treatment options for nonmotor symptoms in PD. More research is needed. 

What’s next?

If you are experiencing any of these symptoms discuss your treatment options with your doctor. 

Published By :

Movement disorders: official journal of the Movement Disorder Society

Date :

Jan 17, 2019

Original Title :

Update on treatments for nonmotor symptoms of Parkinson’s disease-an evidence-based medicine review.

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