Subthalamic stimulation improves sleep disorders and quality of life in patients with Parkinson’s disease

This study investigated the effectiveness of subthalamic deep brain stimulation (S-DBS) for the treatment of patients with Parkinson's disease (PD) and sleep disorders. Researchers suggested that S-DBS improves sleep disorders and quality of life in these patients.

PD is a chronic disorder that affects brain cells. Over time the cells lose their abilities to control body function and movements. This can cause physical symptoms such as tremors and mental symptoms. Sleep disorders are one of the most common mental symptoms of PD. They are associated with depressive symptoms and decrease the quality of life of these patients.

DBS consists of activating specific areas of the brain through electrical impulses. Prior studies showed that S-DBS improved sleep for up to 3 years after surgery. However, the long-term effect of S-DBS on sleep, mood, and quality of life compared to standard medications in patients with PD are not clear.  

This study included information about 159 patients with PD and sleep disorders. Participants were assigned to receive either S-DBS (75) or standard medical treatment (84). The main evaluated outcomes were sleep disorders, quality of life, physical symptoms, depression, and the need for medication. Patients were followed up for 3 years.

S-DBS was associated with significantly better sleep and quality of life at 36-month follow-up. However, the medical treatment group had a worsening of sleep quality. No significant effect was seen in depression. No association was found between sleep disorder, depression, and the need for medication.

This study concluded that S-DBS improved sleep and the quality of life of patients with PD compared to standard medical treatment.

This study included a limited number of participants. Further studies with bigger populations are necessary.