In a nutshell
This study investigated the effectiveness of early deep brain stimulation (DBS) treatment in patients with Parkinson’s disease PD. Researchers suggested that DBS may slow down tremor progression in patients with early PD.
Some background
Parkinson’s disease (PD) is a chronic disease that affects certain brain cells. These cells are responsible for muscle function and body movement. The symptoms can go from tremor to muscle rigidity and impaired balance.
DBS is a treatment option that has been used in patients with advanced disease. It has been shown to improve movement symptoms and quality of life, reducing side effects associated with medications. However, it is not clear if this treatment is as effective in early-stage PD.
Methods & findings
This study included information about 28 patients with early PD. They were randomly assigned to receive DBS and medication (group 1) or medication alone (group 2). At the start and at 6, 12, 18 and 24 months, all patients stopped therapy for one week and the mobility was analyzed.
Tremors during resting periods were worse in patients receiving medication alone when compared to DBS at 24 months. Patients in group 2 had a 2.6 times higher risk of the tremors worsening at 2 months compared to group 1.
More patients receiving medication alone had tremors in previously healthy limbs (legs and/or arms; 86%) than those receiving DBS plus medication (46%). Patients in group 1 also needed less medication at each visit compared to group 2.
The bottom line
This study concluded that DBS is an effective option to treat tremors in patients with early Parkinson’s disease.
The fine print
The population group in this study was quite small. Larger studies are needed.
Published By :
Neurology
Date :
Aug 13, 2018
