Does the time interval between semen processing and insemination affect pregnancy?

This study investigated if the time between semen processing and intrauterine insemination (IUI) affected pregnancy outcomes.

They found that the time interval between semen processing and IUI does not adversely affect pregnancy outcomes.

Intrauterine insemination (IUI) is a procedure whereby sperm are delivered directly to the uterus to facilitate pregnancy. It is the first-line of treatment for unexplained and sub-fertility. In order to ensure the most success, IUI should be performed during ovulation.

Sperm are isolated from the semen and processed. This is time-sensitive and should be done quickly. Following this, the processed sperm is delivered via IUI. It is unknown if the time between sperm processing and insemination has any effect on pregnancy outcomes.

This study investigated whether the time window between processing and insemination affects pregnancy rates in subfertile couples. This study included data from 1,136 couples with fertility issues. Data was collected retrospectively and included information on semen processing, IUI and pregnancy rates. Patients were categorized as delayed (next day) insemination or immediate (1 hr post-processing).

Pregnancy rates were similar in couples who underwent delayed (14%) and immediate (13%) IUI. Analysis of patient characteristics did not find any difference based on age, type of subfertility or sperm motility.

This study concluded that the time interval between semen processing and IUI does not adversely affect pregnancy outcomes.

The authors have assumed that sexual intercourse did not occur in the couples who underwent delayed IUI. This could be a confounding (interfering) factor.

If you are undergoing fertility treatment and have any questions regarding these procedures, please discuss with your doctor.