Welcome to Medivizor!

You're browsing our sample library. Feel free to continue browsing. You can also sign up for free to receive medical information specific to your situation.

Posted by on Sep 13, 2020 in Infertility | 0 comments

In a nutshell

This study investigated if the DNA fragmentation index (DFI) is associated with fertility outcomes. 

They found that lower DFI was associated with better pregnancy rates (PRs). 

Some background

Male infertility (MI) is a common cause of couple infertility. MI is involved in 30-50% of cases. Men with abnormal sperm parameters may have MI. Reduced sperm count (SC) and motility (SM; movement) can lead to MI. The cause of poor sperm parameters is not always clear. One possible cause is DNA damage. 

When sperm DNA is damaged it can lead to many problems. It can affect the SC and quality. DNA damage is measured using the DNA fragmentation index (DFI). This can be measured using different methods. The sperm chromatin structure assay (SCSA) is one of these. DFI and SM are both linked to reduced sperm quality. Some studies suggest that DFI may be directly responsible for reduced SM. It is unclear if DFI and SM are associated with poorer fertility outcomes in couples undergoing infertility treatment. 

Methods & findings

This study included 3000 couples undergoing assisted reproduction (AR). Male patients were asked to provide a semen sample for analysis. DFI  and SM were measured. The main fertility outcome was the pregnancy rate (PR)

Lower DFI was associated with higher PRs. A DFI of 15% or less was associated with a PR of 59.6%. DFI of 30% or higher was associated with a PR of 12.1%. Lower DFI was associated with normal SM. For men with a DFI of 15% or less, 83.6% had normal SM. In men with a DFI of 30% or more, 33.5% had normal SM.

The bottom line

The authors concluded that lower DFI was associated with normal SM and higher PRs.

The fine print

This was an observational study. Different AR methods were used. Other factors could also influence PRs. Live birth rates were not analyzed in this study. More studies are needed. 

What’s next?

If you have any concerns regarding infertility please consult with your doctor.

Published By :

Reproductive biology

Date :

Aug 11, 2020

Original Title :

Importance of a semen analysis report for determining the relationship between SCSA sperm DNA fragmentation index and assisted reproductive technology pregnancy rate.

click here to get personalized updates