In a nutshell
This paper studied whether treating nocturia increased testosterone levels in men with hypogonadism (insufficient production of testosterone).
Some background
Nocturia (having to wake up and urinate at night) leads to sleep disturbances. This can affect testosterone (a sex hormone) secretion. Testosterone contributes to sperm maintenance and sexual function. Additionally, late onset hypogonadism (age-associated decrease of testosterone levels) is reported to be associated with nocturia. It is believed that minimising sleep disturbances will lead to improved testosterone levels.
Methods & findings
Patients who were treated for nocturia with desmopressin (Minirin) had their testosterone level studied.
Men older than 40 years with nocturia and late onset hypogonadism were included in the study. On their first visit for nocturia treatment, patients were examined. Patients' prostate symptom score was determined. This prostate symptom score measures urinary symptoms, with a higher value indicating a worse condition. Laboratory tests were done to determine their testosterone level. On the second visit, patients were administered desmopressin treatment to be taken once daily at bedtime. On the final visit, 12 weeks after desmopressin treatment, patients were examined and similar laboratory tests were performed. Additionally, patients recorded the volume of their urine and their sleeping habits.
62 patients completed the 12 weeks of treatment. 3 patients were reported to have side effects of headache and nausea. After desmopressin treatment there was a significant decrease of prostate symptom score. There were no significant changes in total urine volume.
In patients with low testosterone levels (<3.5ng/mL), serum testosterone (in blood) improved from 2.85 to 3.97ng/mL after treatment. Free testosterone (not bound to other proteins) improved from 3.84 to 4.86pg/mL. Prostate score decreased significantly.
In patients with normal testosterone levels, testosterone levels were unchanged after desmopressin treatment. Prostate score was decreased. Patients urination behaviour were improved.
The bottom line
The authors concluded that desmopressin improved nocturia. Serum testosterone levels increased significantly in men with abnormal testosterone levels after desmopressin treatment.
The fine print
Many other factors can contribute to nocturia and testosterone levels, which might affect the results.
Published By :
Urology
Date :
Apr 01, 2014
