In a nutshell
This aim of this study was to measure the risk of developing dementia in older hypertensive patients receiving treatment with calcium channel blockers (CCBs). The authors concluded that the risk of developing dementia was significantly lower in patients treated with CCBs.
Some background
There are many treatment options available for hypertension. Calcium channel blockers (CCBs) are one type of treatment often prescribed to lower blood pressure, particularly in patients over the age of 60. CCBs work by blocking the transport of calcium in the blood. This can increase the width of the arteries. This allows the blood to flow at a more regular rate and decreases blood pressure.
Unrelated studies have shown that transport of calcium may be associated with increased risk of both Alzheimer's disease and vascular dementia (a decline in thinking and memory skills). It is therefore possible that CCBs may be beneficial in reducing the risk of Alzheimer's disease and vascular dementia in older patients.
Methods & findings
This study examined the records of 82,107 hypertensive patients above 60 years of age. The authors compared the rates of dementia in patients receiving CCBs to those receiving other treatments. Patients were observed for up to 10 years (average 4.4 years) after beginning CCB treatment.
The annual rates of dementia diagnosis were significantly lower in patients receiving CCBs when compared to other treatments. CCB patients were 47% less likely to develop dementia.
Longer treatment times and a higher doseage of CCB also showed a decreased risk for dementia.
The decreased risk of dementia with CCB treatment did not differ depending on age, gender, diabetes, stroke, depression or hyperlipidemia (high fat content in the blood).
The bottom line
The authors concluded that older hypertensive patients receiving CCBs are significantly less likely to develop dementia than those receiving other treatments for hypertension.
The fine print
This data was collected only in Taiwanese patients. Not all other illnesses were taken into account and may affect the risk of dementia.
What’s next?
Consult with your physician if you are concerned about dementia risk.
Published By :
Medicine
Date :
Aug 01, 2016
