Intralesional therapy and Peyronie’s disease

This study looked at different types of intralesional therapy in the treatment of Peyronie's disease (PD). It concluded that different therapies could affect different aspects of PD. 

Peyronie’s disease (PD) is an abnormal curvature of the penis when it is erect. The curvature is caused by scar tissue, called a plaque or lesion, forming in the penis. Surgery to remove the scar tissue is an option to treat PD, though it can be linked to complications. Other therapies include medication and mechanical devices. 

Intralesional therapy (IL) injects proteins, or enzymes, which break down the plaques. There are different proteins available to inject. Which protein is best in the treatment of PD needs to be determined. 

Databases were searched for studies comparing IL therapies in PD treatment. Studies using collagenase clostridium histolyticum (CCH), hyaluronic acid (HA), verapamil (Calan) and interferon 2 alpha (I2A) were included. Studies were assessed for changes in penile curvature and erectile function (EF).

8 studies were looked at. CCH and I2A were the best therapies to improve penile curvature. HA was the best therapy to improve EF. Analysis ranked therapies in percentages. I2A received a rank of 56.9%. CCH received a rank of 56.3%. Verapamil received a rank of 48.5%. HA received a rank of 30.7%. 

This study concluded that CCH and I2A had the best effect on penile curvature. It also concluded that HA had the best effect on EF. 

The authors note that a lot of factors varied between the studies. This may affect this study's results. 

If you would like to learn more about intralesional therapy for PD, talk to your doctor.