In a nutshell
This study examined the factors which could predict insulin-associated weight gain. The authors concluded that diabetes-related distress, insulin dose and age contribute to weight gain in insulin-dependent type 2 diabetes.
Some background
Insulin therapy is used to reduce blood glucose (sugar) levels in patients with type 2 diabetes (T2D). However, patients tend to gain 2-6 kg during the first year of insulin therapy. Identifying factors which may be associated with this increased weight gain may be useful in predicting or preventing weight gain.
Methods & findings
This study aimed to identify predictors of insulin-associated weight gain. This study involved 65 T2D patients.
Patients completed questionnaires before beginning insulin treatment and at 6 and 12 months after beginning insulin treatment. Physical activity was measured using accelerometry (a device that measures movement). HbA1c levels (average blood glucose levels over 3 months) and insulin doses were also monitored.
Body weight increased by an average of 3kg after 12 months.
Diabetes-related distress was associated with weight gain. A higher dose of insulin and increases in insulin dose were both associated with weight gain after 12 months. Older patients who started insulin therapy were also more likely to gain weight.
A reduction in physical activity after commencing insulin treatment was not associated with weight gain.
The bottom line
This study concluded that diabetes-related distress, insulin dose and age contribute to insulin-associated weight gain in T2D patients.
The fine print
This study involved a small number of participants. In addition, it is likely that patients underreported food intake when weight gain was compared to calorie intake.
Published By :
Diabetes Care
Date :
Jul 10, 2014
