Tadalafil in men with benign prostatic hyperplasia and erectile dysfunction

This study aimed to investigate the use of tadalafil (Cialis) in the treatment of both erectile dysfunction (ED) and benign prostatic hyperplasia (BPH). This study found that tadalafil is effective and well tolerated in the treatment of Asian men with ED and BPH.

People diagnosed with benign prostatic hyperplasia (non-cancerous overgrowth of the prostate; BPH) can experience erectile dysfunction (ED). This is the inability to get or keep an erection firm enough to have sexual intercourse. Treatment options include tadalafil (Cialis) or tamsulosin (Flomax). It is unclear which medication is more effective. 

This study included 3 groups of men with BPH and ED. Group A included 361 men who got a placebo (inactive medication). Group B included 362 men who got tadalafil. Group C included 185 men who got tamsulosin. Questionnaires were used to evaluate urinary and sexual functions at the beginning of the stud and after 12 weeks of treatment. 

Group B had a significant improvement from baseline compared to Group A. An higher rate of sexual encounters was noted in Group B (36.62%) compared to group A (15.96%). Improvements in urinary symptoms were seen in 72.2% of patients in group A, 83.9% in group B, and in 78.4% in group C.

SIde effects were similar in the three groups. Most side effects reported were mild and included dizziness, back pain or upper respiratory inflammation.

This study found that tadalafil is effective in the treatment of Asian men with BPH and ED. 

This study only included Asian men so the results may not apply to all ethnicities. Further studies are needed.