This trial aims to see how the timing of triggering the release of the eggs in IVF may affect fertility outcomes. The main outcomes to be investigated are the percentage of normal embryos, mature eggs, and live birth rate. The trial is recruiting in Colorado, USA.
The details
In-vitro fertilisation (IVF) is a procedure where the sperm fertilizes the egg in a laboratory dish outside the body and is then implanted into the woman’s uterus. The ovaries are stimulated to produce eggs that can be retrieved, fertilized and implanted. This study will examine how the timing of triggering the release of the eggs may affect fertility outcomes.
Who are they looking for?
This study is recruiting about 100 women aged between 26 and 44 years who are planning to undergo IVF.
Participants should not have had recurrent miscarriages. They should not have any abnormalities of the uterus, stage 3 or 4 endometriosis, or polycystic ovarian syndrome. Participants should not be using an egg donor. Male partners should not have significant male infertility or abnormal sperm counts.
How will it work
Participants will be randomly assigned to one of two groups. Participants in the first treatment group will undergo ovarian stimulation. The timing of triggering the release of the eggs will occur when 2 follicles reach 18mm, or 1 follicle reaches 18mm and 1 follicle is between 16 and 18mm. Participants in the second treatment group will not receive any intervention.
The number of mature eggs retrieved will be measured after 1 week. The number of normal embryos will be analyzed 4 weeks after the eggs are retrieved. Birth rate will be recorded 9 months after embryo transfer.
