This trial will investigate if endometrial receptivity analysis (ERA) improves outcomes after embryo transfer (ET) in women undergoing fertility treatment. The main outcome will be the live birth after ET. This trial is recruiting in Maryland, the United States.
The details
After in vitro fertilization (IVF) embryos are transferred to the woman's womb. To become pregnant, an embryo must attach to the lining of the womb. This lining is called the endometrium (EDM). The EDM supplies blood and growth factors to the embryo. Embryo transfer (ET) does not always result in pregnancy. Some studies suggest that the success of IVF/ET depends on endometrial receptivity (ER). There is a technique called ER analysis (ERA). This assesses the condition of the EDM. It can be used to determine the right time to perform ET.
This trial will investigate if ERA improves outcomes after ET. The main outcome will be the live birth after embryo transfer.
Who are they looking for?
This study will recruit 800 women undergoing IVF. Participants must have a fertilized embryo with a normal number of chromosomes. They must have at least one embryo for ET.
Women may not take part in the trial if they have a condition affecting the EDM. They may not have conditions that have a negative effect on the reproductive system. Other exclusion criteria include a history of recurrent pregnancy loss and chromosomal abnormalities in the embryos.
How will it work
All patients will undergo a standard IVF cycle and pre-implantation genetic screening (PGS). PGS will determine if the embryos are chromosomally normal. Participants will be randomly assigned to one of two groups. One group will undergo ERA and the embryo will be transferred to the uterus depending on ERA results. In the second group, the embryo will be transferred after a standard protocol to prime the EDM.
