This phase 1 and 2 trial located in Maryland, United States aims to see whether resveratrol can have positive effects on heart and blood vessel health. The outcome to be measured is the change in stiffness of arteries.
The details
Resveratrol is a compound found in the skin of red grapes. Lab studies show that it may help lower blood sugar, improve heart and blood vessel health, and prevent cancer. While resveratrol has been studied in animals, it has not yet been studied in humans. Studies so far suggest that resveratrol could be a nutritional supplement and that is appears safe at a dose of up to 5 grams per day.
Who are they looking for?
This study is recruiting 300 participants who are at least 50 years old. Female articipants should be either menopausal or have had a bilateral oophorectomy (removal of both ovaries). Participants should be healthy overall.
Participants should not be taking cholesterol medications. Participants should not be taking aspirin. Participants should not have HIV, hepatitis B or hepatitis C.
How will it work
This study will involve an initial screening visit and four study visits. Some of the study visits will involve overnight stays. Participants will be screened with a physical exam and medical history. Blood and urine samples will be collected. They will be given a list of foods that they should avoid eating while on the study. Urine samples and body scans will be performed to measure fat and muscle mass. Participants will also undergo exercise tests.
Participants will be randomly assigned to one of 3 treatment groups. Participants in the first treatment group will receive a placebo (drug that has no real effect) twice daily. Participants in the second treatment group will receive 75mg of resveratrol twice daily. Participants in the third treatment group will receive 150mg of resveratrol twice daily. All participants will be followed up for 12 months.
