In a nutshell This study investigated the effects of bevacizumab (avastin) in combination with chemotherapy on the risk of cardiac related events, such as heart failure and cardiac related death. Some background Bevacizumab is a drug which targets a protein called vascular endothelial growth factor A (VEGF-A). By binding to VEGF-A...
Read MoreType(s) of colorectal cancer (CRC)-Adenocarcinoma of the colon Posts on Medivizor
The addition of ganitumab or conatumumab to chemotherapy in the treatment of metastatic colorectal cancer
In a nutshell This study compared the ability of two drugs, ganitumab and conatumumab, to treat patients with metastatic colorectal cancer when added to chemotherapy. Some background Cancer cells express various structures on their surface (called receptors) that may stimulate growth and help avoid destruction by the immune system. Drugs that...
Read MoreThe effect of cetuximab with chemotherapy in patients with unresectable liver metastases
In a nutshell This study explored whether cetuximab (erbitux) can benefit patients with unresectable colorectal liver metastases. The ability to perform surgery to remove part or all of the tumor growth in the liver (the resection rate) was compared between patients receiving cetuximab in combination with chemotherapy, to those receiving chemotherapy...
Read MoreComparing combined versus sequential chemotherapy for patients with advanced colorectal cancer
In a nutshell This trial compared the effect on disease progression and survival of different chemotherapy combinations used in the treatment of patients with metastatic colorectal cancer. Some background Metastatic colorectal cancer (mCRC) is cancer that has spread from the large intestine to other organs and tissues. Chemotherapy...
Read MoreIntermittent versus continuous chemotherapy in advanced colorectal cancer
In a nutshell The aim of this study was to assess the effects of pauses during chemotherapy in patients with advanced colorectal cancer (CRC). Some background In advanced CRC (cancer of the large bowel that has spread to the lymph nodes and other tissues and organs of the body) the cancer is more difficult to remove. Patients usually need...
Read MoreSurgery versus endoscopic resection for malignant colorectal polyps
In a nutshell The present study compared outcomes of two treatment methods for patients with malignant colorectal polyps (MCP): endoscopic versus surgical management. Some background Most colorectal cancers develop from a malignant (cancerous) polyp, an abnormal growth on the inner surface of the large intestine. When a polyp is found, the only...
Read MoreDo elderly or younger patients with stage II colon cancer benefit from adding Oxaliplatin to adjuvant chemotherapy?
In a nutshell This study tested whether chemotherapy after surgery ('adjuvant chemotherapy') including Oxaliplatin and FL (altogether called FOLFOX4) has any benefits in stage II and in elderly patients with colon cancer (CC). The main finding was that the addition of Oxaliplatin to FL as adjuvant...
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