In a nutshell This trial is examining the safety and effectiveness of combination therapy with pembrolizumab (Keytruda) and lenvatinib (Lenvima) for advanced or unresponsive colorectal cancer (CRC) and other solid tumors. The main outcome to be measured will be the objective response rate (ORR; the percentage of participants who have complete...
Read MoreType(s) of colorectal cancer (CRC)-Adenocarcinoma of the colon Posts on Medivizor
Looking for participants to test a new vaccine to treat advanced colorectal cancer
In a nutshell This trial is examining the effectiveness and toxicity of PolyPEPI1018 vaccine in the treatment of advanced colorectal cancer. The main outcome to be measured is tumor response to the treatment. This trial will be conducted in Italy, and Minnesota, US. The details The standard treatment for metastatic (spread to other parts of the body)...
Read MoreLooking for patients with advanced colorectal cancer to a test two different treatment combinations
In a nutshell This phase 3 trial is examining the effectiveness of arfolitixorin versus leucovorin (folinic acid) when added to a combined treatment with 5-fluorouracil, oxaliplatin, and bevacizumab (FOB) to treat advanced colorectal cancer. The main outcome to be measured is the cancer response to the treatment. The details Treatment with...
Read MoreRegorafenib followed by cetuximab is associated with longer survival in the treatment of advanced colorectal cancer
In a nutshell This study investigated the effectiveness and safety of treatment with regorafenib (Stivarga) followed by cetuximab (Erbitux) in the treatment of advanced colorectal cancer. Researchers suggested that this treatment improves survival of these patients. Some background New treatments have become available in the past 20 years to treat...
Read MoreSurgery improves survival of colorectal cancer patients with lung metastasis
In a nutshell This study investigated the outcomes of surgery to lung metastasis (LM; cancer spreads to the lungs) in patients with colorectal cancer. Researchers suggested that lung surgery increases the survival of these patients. Some background Colorectal cancer is one of the major diseases seen in the US. LM appear in 5-15% of patients and...
Read MorePost-surgery complications can affect chemotherapy treatment after surgery in colorectal cancer
In a nutshell This study investigated the post-surgery factors that affect the use of chemotherapy after surgery in colorectal cancer patients. Researchers suggested that post-surgery complications are associated with delay or not receiving chemotherapy treatment. Some background Surgery and post-surgery chemotherapy are the standard...
Read MorePost-surgery risk factors for recurrence in stage 2 and 3 colorectal cancer
In a nutshell This study investigated the risk factors for recurrence (when the cancer comes back) after surgery in patients with stage 2 and stage 3 colorectal cancer. Researchers suggested that high-risk patients can be identified by assessing tumor specific blood levels, tumor spread to the lymphatic system and infiltrative growth (IG; when the...
Read MoreIn what order should chemotherapies be delivered?
In a nutshell This review discussed the use of second-line chemotherapy (therapy after disease progression despite initial treatment) in colorectal cancer. Some background Patients with advanced (spread to lymph nodes and beyond) colorectal cancer often require a second round of chemotherapy following their first treatments. The use of multiple...
Read MoreCalling on patients with colorectal cancer that has spread to the liver to test a drug treatment option
In a nutshell This study is being carried out in New York and New Jersey. It will examine whether adding panitumumab (Vectibix) to chemotherapy reduces the risk of the cancer returning in colorectal cancer patients with liver metastases (cancer that has spread to the liver). The authors will also record any adverse events experienced and patient...
Read MoreDoes continuing to smoke after diagnosis of colorectal cancer affect survival?
In a nutshell This study investigated the effect of smoking on survival in patients with colorectal cancer. Some background Colorectal cancer is the third most common cancer in the world. There is no one cause of colorectal cancer but several environmental and genetic factors are known to contribute to its development. The International...
Read MoreComparing surgical techniques: less invasive surgery reduces the interval between surgery and chemotherapy
In a nutshell This study investigated the effect of the surgical technique on the timing of chemotherapy administration. Some background Colon surgery (colectomy) is the main treatment for curing patients with colorectal cancer. There are 2 possible surgical techniques: laparoscopic surgery or open surgery. Laparoscopic surgery is a more recent,...
Read MoreDoes anastomotic leakage after surgery for colorectal cancer affect survival?
In a nutshell This study investigated the impact of anastomotic leak on patient survival after surgery for colorectal cancer. Some background The main treatment option for patients with colorectal cancer is surgery. One major complication that can occur after surgery is anastomotic leakage. Anastomotic leakage involves the leaking of fluid from...
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