In a nutshell The aim of this study was to evaluate the safety and effectiveness of combining androgen deprivation therapy (ADT) with docetaxel (Taxotere) plus prednisone (Deltasone) in the treatment of metastatic hormone-sensitive prostate cancer (mHSPC). The study found that this combination improved the outcomes of these...
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In a nutshell This study compared autologous stem cell transplant (SCT) to treatment with the proteasome inhibitor and chemotherapy regimen VMP (bortezomib, melphalan, prednisone) for patients with multiple myeloma (MM). It found that SCT led to better outcomes for the initial treatment of MM. Some background MM is a cancer of the plasma cells, a type...
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In a nutshell The study compared the long-term outcomes of prostate surgery (radical prostatectomy; RP) and observation (watchful waiting; WW) in patients with early prostate cancer. The study showed that surgery reduced mortality in these patients. Some background Prostate cancer is one of the most common cancers in American men....
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In a nutshell This study evaluated lenalidomide (Revlimid) maintenance therapy versus placebo for patients with diffuse large B-cell lymphoma (DLBCL). The authors found that lenalidomide increased the number of side effects but did not impact health status. Some background DLBCL is an aggressive type of non-Hodgkin's lymphoma....
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In a nutshell This study investigated the effectiveness of surgery followed by chemotherapy without chemoradiotherapy (CRT) before surgery to treat rectal cancer. Researchers suggested that this treatment improves the outcomes of these patients. Some background Colorectal cancer is the third most common cancer worldwide. The standard...
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In a nutshell This study wanted to find out what the long-term outcomes were for women with ductal carcinoma in situ (DCIS) who had breast-conserving therapy. The study found that after 10 years, the risk of recurrence of cancer in the same breast was very low. Some background There are a number of treatment options for DCIS. Some women opt...
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In a nutshell This study aimed to investigate the safety and effectiveness of obinutuzumab in combination with fludarabine and cyclophosphamide in fit patients with chronic lymphocytic leukemia. This study concluded that this combination as frontline treatment is a promising option for these...
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In a nutshell This study investigated whether a combination of bortezomib (Velcade), melphalan (Alkeran) and prednisone (Deltasone) was more effective than lenalidomide (Revlimid) and dexamethasone (Decadron) followed by lenalidomide maintenance for newly diagnosed multiple myeloma (MM). The main finding was that age and disease risk influenced the...
Read MoreIn a nutshell This study is looking for patients with newly diagnosed multiple myeloma (MM) to try different treatment regimens. The main outcome that will be measured is the number of patients who do not experience cancer worsening after treatment. This trial is recruiting in Chicago, Illinois, United States. The details There are several...
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In a nutshell This study compared RTXM83 to rituximab (Rituxan) to see if it is as effective and safe for patients with diffuse large B-cell lymphoma. This study concluded that RTXM83 is as effective and safe as rituximab. Some background Diffuse large B-cell lymphoma (DLBCL) is an aggressive type of non-Hodgkin’s lymphoma. This type...
Read MoreIn a nutshell This phase 2 study is evaluating the effectiveness of a new combination therapy for small lymphocytic lymphoma (SLL). The main outcome to be measured will be the number of patients who have a complete disappearance of all signs of cancer. This study is recruiting in Rochester, New York, US. The details Typical treatments for SLL include...
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In a nutshell This study is searching for patients with previously untreated chronic lymphocytic leukemia (CLL) to try a new treatment combination containing obinutuzumab (Gazyva) or obinutuzumab/bendamustine (Treanda) to shrink the tumor (debulking) before treatment with venetoclax (Venclexta). The main outcome that will be measured is the number...
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