In a nutshell This study compared the survival rates for older patients with early-stage breast cancer (BC) receiving hormone therapy (HT), radiation (RT), both or none after breast-conserving surgery (BCS). The data showed that RT and HT in combination and RT alone may lead to higher survival expectancy than HT alone. Some...
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In a nutshell This trial evaluated strategies to improve diarrhea as a side effect of neratinib (Nerlynx) treatment in patients with HER2-positive breast cancer (BC). The authors showed that slowly increasing the doses of neratinib or taking anti-diarrhea medication can improve this side effect. Some background Neratinib (Nerlynx) is a targeted...
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In a nutshell The study evaluated long-term outcomes of combining hypofractionated intensity-modulated radiation therapy (H-IMRT) with prone-positioning in patients after conservation surgery for breast cancer. The authors found that this combination safely controlled cancer locally without affecting regional lymph nodes. Some background Adjuvant...
Read MoreIn a nutshell This study aimed to compare the outcomes for patients with early breast cancer who received 6- or 12-months trastuzumab after surgery. This study concluded that the standard duration of trastuzumab after surgery should remain 12 months. Some background Trastuzumab (Herceptin) is a targeted...
Read MoreIn a nutshell This study aimed to investigate the combination of letrozole and taselisib as a neoadjuvant treatment (before surgery) in patients with hormone receptor-positive, HER2-negative, early stage breast cancer. This study concluded that this treatment...
Read MoreIn a nutshell This study aimed to investigate the effectiveness and safety of talazoparib as a neoadjuvant agent (treatment before surgery) in patients with BRCA mutation and operable breast cancer. This study concluded that this treatment was a safe and effective in these patients. Some...
Read MoreIn a nutshell This phase 3 trial will investigate the effect of bupropion (Wellbutrin) to treat fatigue in patients with breast cancer (BC). The main outcomes will be fatigue, quality of life and depression. This trial is recruiting across the United States. The details After treatment for breast cancer (BC), many women report feeling...
Read MoreIn a nutshell This trial is examining the effectiveness and safety of standard chemoradiation vs a PET base chemoradiation combination in patients with non-small cell lung carcinoma (NSCLC). The main outcomes to be measured will be side effects and survival without cancer growing or spreading. The details A treatment option for...
Read MoreIn a nutshell This phase 2 trial is examining the effectiveness and safety of durvalumab (Imfinzi) in the treatment of advanced rectal cancer that is not prone to genetic abnormalities. The main outcomes to be measured will be tumor response to the treatment and side effects. This trial is being conducted in the US. The details The standard treatment...
Read MoreIn a nutshell This study compared the survival outcomes of patients with rectal cancer who underwent short- or long-course radiation therapy (RT). Researchers suggested that long-course RT was associated with greater tumor response and survival. Some background Colorectal cancer is the third most common cancer diagnosed in the United States. The...
Read MoreIn a nutshell This trial is examining the effectiveness of chemotherapy followed by a less invasive surgery for early rectal cancer. The main outcome will be the number of patients keeping their rectum. This trial is being conducted in Canada and the United States. The details Rectal cancer is one of the most common cancers in the US. The standard...
Read MoreIn a nutshell This study aimed to investigate two techniques used to treat low rectal cancer, abdominoperineal resection (APR) and intersphincteric resection (ISR). This study found there was no significant difference in long-term outcomes for APR and ISR. Some background APR is a common surgery to remove low rectal cancers. A low rectal...
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