In a nutshell This trial was carried out to look at the effectiveness of nivolumab (Opdivo) and nivolumab plus ipilimumab (Yervoy) as neoadjuvant therapy (NAT; treatment before surgery) in treating operable non-small cell lung cancer (NSCLC). The authors found that ipilimumab and nivolumab treatment before surgery provides better...
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In a nutshell This study evaluated whether chemoradiotherapy (CRT) before surgery improves the outcomes of patients with stage II-III colorectal cancer (CRC). The study found that CRT before surgery may not be needed in certain patients with low-risk disease. Some background CRC is the third most common cancer worldwide. The standard therapy for...
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In a nutshell This study investigated if reducing therapy duration could reduce side effects in patients but still be effective in patients with stage II colorectal cancer (CRC). This study showed that in certain patients a 3-month treatment duration can be considered. Some background Patients with colorectal cancer (CRC) can be treated...
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In a nutshell This article looked at 5-year outcomes of intraoperative radiation therapy (IORT) for breast cancer (BC). The authors found that IORT may have a higher rate of cancer return compared to whole-breast radiation therapy (WBRT). Some background BC is one of the most common forms of cancer found in women. Standard care for BC is usually a...
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In a nutshell This study investigated whether adding oral S-1 (Teysuno) to hormonal therapy improved outcomes in patients with estrogen receptor (ER)-positive and HER2-negative primary breast cancer (BC). The data showed that the combination of S-1 with hormonal therapy could be a potential treatment option for these patients. Some background...
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In a nutshell This article looked at the use of partial breast irradiation (PBI) versus whole-breast irradiation (WBI) as a treatment for breast cancer (BC). The authors found that PBI offered similar results when compared to WBI. Some background BC remains one of the most common forms of cancer found in women. Standard care for BC remains...
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In a nutshell This trial looked at the use of short-course radiotherapy (RT) followed by chemotherapy (CT) and delayed surgery to reduce distant metastases (tumor spread) in patients with locally advanced rectal cancer (LARC). The trial found that this treatment was more effective in controlling distant metastases when compared to standard...
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In a nutshell This trial is looking to examine the use of radiation on a shorter schedule of 5 days in a row is a safe and effective way to prevent breast cancer (BC) from coming back in people who have had a mastectomy (surgical removal of the breast). The main outcomes that are to be measured are local and regional disease recurrence. This trial is to...
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In a nutshell This study was carried out to assess the use of radiotherapy (RT) after mastectomy (surgical removal of the breast) for triple-negative breast cancer (TNBC) that has spread to the lymph nodes. The authors found that RT after surgery was associated with improved survival in patients with larger tumors. Some background Triple-negative...
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In a nutshell This study aimed to investigate the outcomes of accelerated partial breast irradiation (ABPI) with TomoTherapy (TT) after breast conservative surgery (BCS) in patients with invasive breast cancer. This study concluded that this treatment is safe and effective with good long-term outcomes in these patients. Some...
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In a nutshell This study compared whole breast irradiation (WBI) to partial breast irradiation (PBI) following breast-conserving surgery (BCS) in patients with low-risk breast cancer. The study showed similar survival between the 2 treatments, while PBI gave better cosmetic results. Some background Patients with low-risk breast...
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In a nutshell This study compared the effectiveness of breast-conserving surgery (BCS) to mastectomy (breast-removal surgery) after chemotherapy in patients with breast cancer. The authors found that BCS does not result in a lower survival in these patients. Some background BC is one of the most common forms of cancer in women. Standard care...
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