In a nutshell This study compared the outcomes of patients with rectal cancer treated with either laparoscopy (LPS; removal of the tumor by using a cable with a camera inserted near the tumor) or open surgery. Researchers found no differences in outcomes between LPS and open surgery for these patients. Some background Treatment for rectal...
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Looking for patients with triple negative breast cancer to test atezolizumab
In a nutshell This trial is examining the effectiveness of chemotherapy and atezolizumab (Tecentriq), given before surgery, for triple negative breast cancer. The main outcomes to be measured will be response in the breast tissue and lymph nodes and survival. The details Triple negative breast cancer is not dependent on the HER2 receptors or...
Read MoreLymph node surgery for early stage breast cancer
In a nutshell This study looked at the impact of removing lymph nodes (immune glands) from the armpit (axillary nodes) in the treatment of patients with breast cancer. The study found that removing the axillary lymph nodes did not signifcantly improve survival in patients with early stage breast cancer. Some background Breast cancer has the...
Read MoreImpact of surgery for early-stage invasive breast cancer
In a nutshell This study aimed to evaluate patients treated for early stage breast cancer in terms of overall survival and recurrence risks. Among patients with early-stage breast cancer; clinical outcomes more than 10 years after diagnosis did not differ between breast-conserving therapy plus radiation or mastectomy plus radiation...
Read MoreSearching for stage I-III breast cancer patients to test omega-3 supplementation
In a nutshell This trial aims to evaluate the use of omega-3 fatty acid supplements to prevent side effects caused by aromatase inhibitors. Aromatase inhibitors can cause arthralgia (bone and joint pain). The main outcomes to be investigated are the change in pain score and the change in joint symptoms. This trial is taking place in Cleveland and...
Read MoreSearching for younger breast cancer survivors to test behavioral techniques for improved quality of life
In a nutshell This phase 3 trial aims to evaluate the effectiveness of mindfulness meditation or survivorship education in improving behavioral symptoms in younger stage 0-III breast cancer survivors. The main outcome to be investigated is the change in depressive symptoms. This trial is taking place in the states of California, Maryland and...
Read MoreSearching for patients with HER2 negative breast cancer to test whether aspirin can prevent cancer recurrence
In a nutshell This phase 3 trial aims to evaluate how well aspirin can work to prevent recurrence of breast cancer. The main outcome to be investigated is invasive disease free survival. Other outcomes include overall survival (time from treatment until death from any cause) and the incidence of heart disease. This trial is taking place in 985...
Read MoreSearching for triple negative breast cancer patients to test the effectiveness of pembrolizumab
In a nutshell This phase 3 trial aims to evaluate how effective pembrolizumab (Keytruda) is at treating triple negative breast cancer. The main outcome to be investigated is the invasive disease free survival. Other outcomes include the overall survival (time from treatment until death from any cause) and side effects. This trial is taking place...
Read MorePost-surgery complications can affect chemotherapy treatment after surgery in colorectal cancer
In a nutshell This study investigated the post-surgery factors that affect the use of chemotherapy after surgery in colorectal cancer patients. Researchers suggested that post-surgery complications are associated with delay or not receiving chemotherapy treatment. Some background Surgery and post-surgery chemotherapy are the standard...
Read MoreHow soon after surgery should breast cancer patients start on chemotherapy?
In a nutshell This study aimed to investigate the influence of the time of starting adjuvant chemotherapy on survival outcomes in different types of breast cancer. This study concluded that more aggressive breast cancers require early adjuvant chemotherapy. Some background Surgery to remove the tumor is a commonly used treatment method for...
Read MoreSearching for patients with stage II or III non-small cell lung cancer to test a type of radiation therapy
In a nutshell This phase I/II trial aims to determine the effectiveness and safety of combining hypofractionated proton therapy with chemotherapy in treating patients with stage II or stage III non-small-cell lung cancer (NSCLC). The main outcome of the trial will be maximum tolerated dose (MTD – highest dose of the treatment that does not cause...
Read MoreThe beneficial effects of trastuzumab on locoregional control in HER2-positive breast cancer patients.
In a nutshell This study investigated the effects of trastuzumab (Herceptin) on the locoregional control (management in the area in which it arose) of patients with HER2-positive breast cancer (HER2+BC) following radiotherapy (RT). Trastuzumab administered alongside RT was found to be associated with a significantly reduced rate of locoregional...
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