In a nutshell This study aimed to investigate the GIMEMA LAL-1308 treatment protocol in young patients with Philadelphia chromosome-negative acute lymphoblastic leukemia. This study concluded that this treatment protocol was safe and effective for these patients. Some background Adolescents and young adults...
Read MoreCurrent disease status-First occurrence of the leukemia Posts on Medivizor
Ivosidenib combined with azacitidine for patients with mutant IDH1 acute myeloid leukemia
In a nutshell This study aimed to investigate the safety and effectiveness of the combination of ivosidenib (Tibsovo) and azacitidine (Vidaza) in patients with acute myeloid leukemia (AML) with isocitrate dehydrogenase 1 (IDH1) mutation (permanent change). This study concluded that this combination was well tolerated and...
Read MoreComparing salvage treatments for relapsed/refractory acute myeloid leukemia
In a nutshell This study aimed to compare outcomes of salvage chemotherapy for patients with relapsed or refractory acute myeloid leukemia. This study concluded that the CLAG-M regimen (cladribine, cytarabine, filgrastim, and mitoxantrone) followed by transplant is a suitable salvage treatment for these patients. Some...
Read MoreCladribine, G-CSF, cytarabine and aclarubicin in patients with relapsed/refractory acute myeloid leukemia
In a nutshell This study aimed to investigate the safety and effectiveness of C-CAG including cladribine (Leustatin), granulocyte colony-stimulating factor (G-CSF, Neupogen), cytarabine (Cytosar-U), and aclarubicin (Aclacinon) in patients with relapsed/refractory (r/r) acute myeloid leukemia (AML). This study...
Read MoreLooking for patients with untreated chronic lymphocytic leukemia to trial a treatment combination.
In a nutshell This trial is aiming to examine the effectiveness of zanubrutinib (Brukinsa) in combination with rituximab (Rituxan) to treat chronic lymphocytic leukemia (CLL). The main outcome to be measured is the number of patients who achieve the reduction or disappearance of their CLL. This trial is being carried out in Texas, the...
Read MoreWhat is the best intrathecal therapy for children with acute lymphoblastic leukemia?
In a nutshell This study aimed to investigate if postinduction central nervous system (CNS; brain and spine) protection with intrathecal (injection into the spine) triple therapy (ITT) would improve the outcomes for pediatric patients with acute lymphoblastic leukemia (ALL) when compared to intrathecal methotrexate (MTX; Otrexup)...
Read MoreThe effects of ofatumumab in combination with chemotherapy in patients with (Ph)-negative B-cell acute lymphoblastic leukemia
In a nutshell The study evaluated outcomes of combining ofatumumab (Arzerra) with hyper-CVAD chemotherapy in patients with Philadelphia chromosome (Ph)-negative CD20-positive B-cell acute lymphoblastic leukemia (B-ALL). The authors found that the combination was safe and effective in such patients. Some background Philadelphia chromosome (Ph) is a...
Read MoreSearching for patients with previously untreated chronic lymphocytic leukemia to try a treatment combination
In a nutshell This trial is comparing the effectiveness of a combined regimen of venetoclax (Venclexta) and obinutuzumab (Gazyva) or VEN-G to an existing drug regimen of fludarabine (Fludara), cyclophosphamide (Cytoxan), and rituximab (Rituxan) or FCR, or bendamustine (Treanda) and rituximab...
Read MoreTime from diagnosis to treatment and the outcomes for patients with acute myeloid leukemia
In a nutshell This study aimed to investigate the relationship between time from diagnosis to treatment start and outcomes for patients with acute myeloid leukemia. This study concluded that time from diagnosis to treatment is not related to survival in these patients. Some background Untreated acute myeloid leukemia...
Read MoreComparing front-line treatments for older patients with chronic lymphocytic leukemia
In a nutshell This study aimed to compare the safety and effectiveness of bendamustine–rituximab (BR) and chlorambucil–rituximab (Chl-R) as a front-line treatment in older patients with chronic lymphocytic leukemia (CLL). This study concluded that both treatments are good options for these...
Read MoreComparing induction treatment regimens for patients with acute myeloid leukemia
In a nutshell This study aimed to investigate the safety and effectiveness of combining daunorubicin (Cerubidine) and cytarabine (Cytosar-U) compared to idarubicin (Idamycin) and cytarabine as induction treatment for patients with acute myeloid leukemia. This study concluded that the idarubicin and cytarabine combination...
Read MoreAcalabrutinib in patients with relapsed or refractory chronic lymphocytic leukemia
In a nutshell This study aimed to investigate if acalabrutinib (Calquence) was safe and effective as a treatment for patients with relapsed or refractory chronic lymphocytic leukemia. This study concluded that acalabrutinib was safe and effective in these patients. Some background Acalabrutinib is commonly...
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