In a nutshell
This study looked at the relationship between obesity and rheumatoid arthritis (RA) remission (no evidence of disease). The authors concluded that obesity decreases the chances of achieving or sustaining remission and affects disease activity in patients with RA.
Some background
Patients with rheumatoid arthritis (RA) often experience pain caused by inflammation of their joints. Identifying and minimizing risk factors for RA is important. This may improve disease activity and quality of life for patients. Some studies have previously reported a link between obesity and the risk of developing RA.
Obese patients are known to have higher disease activity than non-obese patients. Limited mobility associated with obesity may make swollen and painful joints worse. In addition, obesity may affect a patient’s response to different drug treatments for RA. Whether obesity affects the chances of RA remission has not been fully studied.
Methods & findings
The authors reviewed a number of different studies to assess the link between obesity and the ability to achieve remission in RA patients. A total of 20 separate studies were included in analysis. The proportion of obese patients ranged from 10 to 31%.
Data from 8 studies showed that obese patients are 43% less likely to achieve remission than non-obese patients. Obese patients that did achieve remission were 51% less likely to sustain remission compared to non-obese patients.
Results from 9 studies showed that disease activity was significantly higher in obese patients. Obesity was also linked to higher number of tender joints and signs of inflammation. Pain and physical function were worse in obese patients.
3 separate studies found no link between obesity and mortality rates in RA patients.
The bottom line
The authors concluded that obesity decreases the chance of RA remission. Obesity was also associated with a decrease in physical function, higher disease activity, and increased pain.
The fine print
Data was collected from a number of different studies. Measurements and outcomes varied between studies.
Published By :
Arthritis Care & Research
Date :
May 09, 2016
