In a nutshell
This study investigated if garlic supplementation improves rheumatoid arthritis (RA) symptoms and inflammation.
They found that garlic supplements improved pain and quality of life (QoL) in these patients.
Some background
Rheumatoid arthritis (RA) is a chronic condition. It causes painful inflammation in the joints. This leads to joint damage and disability. RA also has a negative effect on quality of life (QoL). This makes it more difficult for patients to complete daily activities. The cause of RA is unknown. Oxidative stress (OS) may contribute to RA. OS is caused by reactive oxygen species (ROS). ROS are a type of chemical that can cause damage to cells. This causes tissue damage and also stimulates an immune response.
Normally the body responds to ROS with anti-oxidants (ATOs). ATOs neutralize ROS and prevent further damage. Patients with RA have lower ATO levels in the blood. Garlic is a natural source of ATOs. It is unclear if garlic supplementation improves RA symptoms and inflammation.
Methods & findings
This study included 62 women with RA. Patients were randomly assigned to garlic supplements (500mg per day) or placebo (inactive tablets). The study lasted 8 weeks. RA symptoms were measured at the beginning and end of the study. These included QoL and disability. Total antioxidant capacity (TAC) was measured on blood samples. A chemical called malondialdehyde (MDA) was also measured. This is an indicator of OS.
TAC and MDA levels were similar in both groups at the start of the trial. Patients with garlic supplements had higher TAC and lower MDA at 8 weeks. This indicates that ROS levels were lower. QoL and disability scores were improved in the garlic group compared to the placebo. There was a significant improvement in pain scores in the garlic group.
The bottom line
The authors concluded that garlic supplements improved pain, QoL and inflammation markers in women with RA.
The fine print
The number of patients in this study was very low. It was also a relatively short study. Larger long-term studies are needed.
What’s next?
If you have any concerns regarding RA management please consult with your doctor.
Published By :
International journal of clinical practice
Date :
Mar 11, 2020
