In a nutshell
This study examined the factors that predict changes in weight in rheumatoid arthritis patients.
Some background
In rheumatoid arthritis (RA), the immune system begins to attack the healthy joints, causing pain, inflammation, and destruction of the joints. RA patients who have a low body mass index (BMI– measure of body fat based on weight and height) have a poorer outcome, including greater joint destruction and greater mortality. A low BMI may therefore be associated with a more aggressive form of the disease. Because greater weight loss increases the risk of poor outcomes, identifying the factors that can predict changes in BMI is important.
Methods & findings
This study aimed to determine the factors which can predict changes in BMI in rheumatoid arthritis patients.
This study involved 1474 RA patients. Various factors, including age, inflammation, smoking and the use of treatments including methotrexate (Trexall), prednisone (Deltasone), and anti-TNF therapies (such as infliximab [Remicade]) were assessed.
Greater inflammation was associated with a 32% increased risk of weight loss. Older age and smoking were also associated with a greater risk of weight loss. Methotrexate use was associated with a lower risk of weight loss. Prednisone and anti-TNF therapies were not associated with weight loss.
The bottom line
This study concluded that greater age, greater inflammation and smoking can predict weight loss over time in RA patients.
The fine print
This study involved a greater number of male RA patients compared to the general RA population. In addition, drug compliance was not examined so it’s unknown whether the presence or absence of certain drugs may have influenced results
What’s next?
Consult your physician regarding the mechanisms that can be taken to modify the factors which are associated with weight loss.
Published By :
The Journal of Rheumatology
Date :
Apr 01, 2015
