In a nutshell
This study examined whether various characteristics of rheumatoid arthritis can predict the severity of cardiovascular disease.
Some background
Rheumatoid arthritis (RA) is caused by an immune attack on the joints. The severity varies between patients. Some patients may have persistent disease while others may have flare-ups. Some patients may even enter remission (no signs of symptoms of disease) after treatment. RA patients can develop cardiovascular disease (CVD). CVD is the narrowing or blockage of blood vessels due to the build-up of fatty plaque deposits on the walls of arteries. This can lead to a cardiovascular event such as a heart attack or stroke. Certain factors may increase the risk of CVD in RA patients. It is believed that RA flares can lead to a worse CVD outcome in comparison to remission. Patients that have a more severe form of RA may also have a worse CVD outcome.
Methods & findings
This study aimed to determine whether flares, remission and severity of RA are associated with CVD in RA patients.
This study involved 525 RA patients and 534 patients who did not have RA. RA flares, remission and severity were recorded for each RA patient. The severity of CVD was measured in RA patients and patients who did not have RA.
For every 6 weeks spent with an RA flare there was a 7% increase in CVD risk. RA patients in remission had a similar severity of CVD to non-RA participants. The risk of CVD was 8% higher in RA patients with medium severity of disease. The risk of CVD was 18% higher in RA patients that had a higher severity of the disease.
The bottom line
This study concluded that RA flares and a greater severity of the disease increase the risk of CVD in RA patients.
The fine print
The assessment of flares and remission was based on patients seeking medical attention. Some patients may not have seen a physician during flares or when in remission.
What’s next?
Consult your physician regarding the options available to reduce inflammation and improve the management of flares.
Published By :
Annals of the rheumatic diseases
Date :
Jan 30, 2015
